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Therefore, we explored the NH of the VSN in TLE patients in this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The sample included 52 patients with left temporal lobe epilepsy, 83 patients with right temporal lobe epilepsy, and 68 healthy controls. The NH method was utilized to analyze the resting-state functional magnetic resonance imaging data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to the controls, rTLE patients had significantly higher NH in the bilateral postcentral gyrus, and significantly lower NH in the bilateral Rolandic operculum and the right superior temporal gyrus (STG). The NH values of the left postcentral gyrus were significantly higher in lTLE patients than in the healthy controls, and lTLE patients had lower NH in the right Rolandic operculum. The altered NH in the postcentral gyrus was negatively correlated with the illness duration, and the decreased NH in the left Rolandic operculum was negatively correlated with the executive control reaction time (ECRT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings suggest that altered NH of the postcentral gyrus, Rolandic operculum and STG might be associated with the pathophysiology of TLE, and thus, highlight the contribution of the VSN to the pathophysiology of TLE.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpsyt.2022.877956","type":"journal-article","created":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T05:20:20Z","timestamp":1655443220000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Abnormal Ventral Somatomotor Network Homogeneity in Patients With Temporal Lobe Epilepsy"],"prefix":"10.3389","volume":"13","author":[{"given":"Dongbin","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoshi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingan","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujun","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,6,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/S0140-6736(18)32596-0","article-title":"Epilepsy in adults.","volume":"393","author":"Thijs","year":"2019","journal-title":"Lancet."},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21082955","article-title":"The sodium channel B4-subunits are dysregulated in temporal lobe epilepsy drug-resistant patients.","volume":"21","author":"Sheilabi","year":"2020","journal-title":"Int J Mol Sci."},{"key":"B3","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.yebeh.2018.06.025","article-title":"Associated and predictive factors of quality of life in patients with temporal lobe epilepsy.","volume":"86","author":"Chen","year":"2018","journal-title":"Epilepsy Behav."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1046\/j.1528-1157.2001.02001.x","article-title":"Seizure outcome after temporal lobectomy: current research practice and findings.","volume":"42","author":"McIntosh","year":"2001","journal-title":"Epilepsia."},{"key":"B5","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.yebeh.2015.06.005","article-title":"Network analysis for a network disorder: the emerging role of graph theory in the study of epilepsy.","volume":"50","author":"Bernhardt","year":"2015","journal-title":"Epilepsy Behav."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1152\/jn.00338.2011","article-title":"The organization of the human cerebral cortex estimated by intrinsic functional connectivity.","volume":"106","author":"Yeo","year":"2011","journal-title":"J Neurophysiol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1002\/mrm.1910340409","article-title":"Functional connectivity in the motor cortex of resting human brain using echo-planar MRI.","volume":"34","author":"Biswal","year":"1995","journal-title":"Magn Reson Med."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1038\/s41380-019-0574-2","article-title":"Intrinsic connectomes are a predictive biomarker of remission in major depressive disorder.","volume":"25","author":"Korgaonkar","year":"2020","journal-title":"Mol Psychiatry."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1038\/mp.2017.3","article-title":"Neural mechanisms of mismatch negativity dysfunction in schizophrenia.","volume":"22","author":"Lee","year":"2017","journal-title":"Mol Psychiatry."},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2014.00092","article-title":"Distinct regions of the cerebellum show gray matter decreases in autism. 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