{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T07:31:32Z","timestamp":1774942292011,"version":"3.50.1"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T00:00:00Z","timestamp":1661904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>We previously demonstrated that flurbiprofen increased arterial oxygen partial pressure and reduced intrapulmonary shunts. The present study aims to investigate whether flurbiprofen improves intraoperative regional cerebral oxygen saturation (rScO<jats:sub>2<\/jats:sub>) and reduces the incidence of postoperative delirium (POD) in elderly patients undergoing one-lung ventilation (OLV).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred and twenty patients undergoing thoracoscopic lobectomy were randomly assigned to the flurbiprofen-treated group (<jats:italic>n<\/jats:italic> = 60) and the control-treated group (<jats:italic>n<\/jats:italic> = 60). Flurbiprofen was intravenously administered 20 minutes before skin incision. The rScO<jats:sub>2<\/jats:sub> and partial pressure of arterial oxygen (PaO<jats:sub>2<\/jats:sub>) were recorded during the surgery, and POD was measured by the Confusion Assessment Method (CAM) within 5 days after surgery. The study was registered in the Chinese Clinical Trial Registry with the number ChiCTR1800020032.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with the control group, treatment with flurbiprofen significantly improved the mean value of intraoperative rScO<jats:sub>2<\/jats:sub> as well as the PaO<jats:sub>2<\/jats:sub> value (P &amp;lt; 0.05, both) and significantly reduced the baseline values of the rScO<jats:sub>2<\/jats:sub> area under threshold (AUT) (<jats:italic>P<\/jats:italic> &amp;lt; 0.01) at 15, 30, and 60 min after OLV in the flurbiprofen-treated group. After surgery, the POD incidence in the flurbiprofen-treated group was significantly decreased compared with that in the control group (<jats:italic>P<\/jats:italic> &amp;lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Treatment with flurbiprofen may improve rScO<jats:sub>2<\/jats:sub> and reduce the incidence of POD in elderly patients undergoing thoracoscopic one-lung ventilation surgery for lung cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical trial registration<\/jats:title><jats:p><jats:ext-link>http:\/\/www.chictr.org\/cn\/<\/jats:ext-link>, identifier ChiCTR1800020032.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpsyt.2022.889637","type":"journal-article","created":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T05:37:13Z","timestamp":1661924233000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Flurbiprofen used in one-lung ventilation improves 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