{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T03:48:36Z","timestamp":1780976916521,"version":"3.54.1"},"reference-count":57,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T00:00:00Z","timestamp":1667520000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to investigate the correlation between changes in regional cerebral oxygen saturation (rSO2) and postoperative delirium in older adults undergoing major abdominal surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>This prospective study enrolled older adults scheduled for elective major abdominal surgery at the Second Affiliated Hospital of Anhui Medical University from August 2021 to January 2022. The change in rSO2 from baseline was determined using the hypo-to-hypercapnic test. The main study outcome was the occurrence of postoperative delirium.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 101 participants were included for analysis, of whom 16 (15.8%) developed postoperative delirium. Compared with non-delirium participants, the mean arterial pressure and heart rate were not significantly different in the postoperative delirium group at T0, T1, T2, T3, T4, and T6 (all P<jats:sub>interaction<\/jats:sub> &amp;gt; 0.05), but the delirium group had lower pH, lower PaO2, and higher lactate levels at T4, T5, and T6 (all P<jats:sub>interaction<\/jats:sub> &amp;lt; 0.05). rSO2 at T0, T1, T2, T3, T4, and T6 was 69.0 (63.2\u201375.2), 70.7 \u00b1 7.3, 68.2 \u00b1 7.5, 72.1 \u00b1 8.0, 69.9 \u00b1 7.8, 67.4 \u00b1 7.2, and 71.7 \u00b1 8.1, respectively. The postoperative change in rSO2 during the hypercapnia test (T\u0394rSO2%) was 6.62 (5.31\u20139.36). Multivariable analysis showed that the Cumulative Illness Rating Scale (odd ratio, OR = 1.89, 95% confidence interval, CI: 1.10\u20133.25, <jats:italic>P<\/jats:italic> = 0.021), preoperative albumin levels (OR = 0.67, 95% CI: 0.48\u20130.94, <jats:italic>P<\/jats:italic> = 0.022), rSO2 at T4 (OR = 0.61, 95% CI: 0.41\u20130.89, <jats:italic>P<\/jats:italic> = 0.010), and postoperative T\u0394rSO2% (OR = 0.80, 95% CI: 0.66\u20130.98, <jats:italic>P<\/jats:italic> = 0.028) were independently associated with postoperative delirium in older adults undergoing elective abdominal surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The rSO2 measured at T4 and postoperative T\u0394rSO2% were independently associated with postoperative delirium in older adults undergoing elective abdominal surgery.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpsyt.2022.907870","type":"journal-article","created":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T10:22:39Z","timestamp":1667557359000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Association between the reactivity of local cerebral oxygen saturation after hypo-to-hypercapnic tests and delirium after abdominal surgery in older adults: A prospective study"],"prefix":"10.3389","volume":"13","author":[{"given":"Jie","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kui","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling-Ling","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Qiong","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian-Wen","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,11,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1016\/j.jamcollsurg.2006.08.026","article-title":"Surgical risk factors, morbidity, and mortality in elderly patients.","volume":"203","author":"Turrentine","year":"2006","journal-title":"J Am Coll Surg."},{"key":"B2","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1097\/SLA.0000000000003402","article-title":"Frailty in older patients undergoing emergency laparotomy: results from the UK observational emergency laparotomy and frailty (ELF) study.","volume":"273","author":"Parmar","year":"2021","journal-title":"Ann Surg."},{"key":"B3","article-title":"Increased mortality in the elderly after emergency abdominal surgery.","volume":"61","author":"Svenningsen","year":"2014","journal-title":"Dan Med J."},{"key":"B4","doi-asserted-by":"publisher","first-page":"216","DOI":"10.4240\/wjgs.v5.i7.216","article-title":"Emergency laparotomy in octogenarians: a 5-year study of morbidity and mortality.","volume":"5","author":"Green","year":"2013","journal-title":"World J Gastrointest Surg."},{"key":"B5","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1093\/bja\/aes165","article-title":"Variations in mortality after emergency laparotomy: the first report of the UK Emergency Laparotomy Network.","volume":"109","author":"Saunders","year":"2012","journal-title":"Br J Anaesth."},{"key":"B6","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1016\/j.jamcollsurg.2015.12.026","article-title":"Optimal perioperative management of the geriatric patient: a best practices guideline from the american college of surgeons NSQIP and the American geriatrics society.","volume":"222","author":"Mohanty","year":"2016","journal-title":"J Am Coll Surg."},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-016-0329-8","article-title":"Frailty and postoperative outcomes in older surgical patients: a systematic review.","volume":"16","author":"Lin","year":"2016","journal-title":"BMC Geriatr."},{"key":"B8","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1001\/archsurg.1949.01240030899015","article-title":"The elderly patients a surgical risk; an analysis of 322 operations performed on 244 patients 60 years or age and over.","volume":"58","author":"Parsons","year":"1949","journal-title":"Arch Surg."},{"key":"B9","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.surge.2019.06.003","article-title":"Emergency laparotomy research methodology: a systematic review.","volume":"18","author":"Nally","year":"2020","journal-title":"Surgeon."},{"key":"B10","year":"2010","journal-title":"NICE Clinical Guideline 103. 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