{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T11:04:59Z","timestamp":1793012699611,"version":"4.5.0"},"reference-count":42,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T00:00:00Z","timestamp":1663632000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018977","name":"Anhui Office of Philosophy and Social Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018977","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine the relationship between fear of recurrence and depression in patients with cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>Two hundred and fifty-nine participants completed self-report questionnaires, including the Fear of Progression Questionnaire-Short Form, Rumination Inventory, Cognitive Emotion Regulation Questionnaire (Chinese version), and Center for Epidemiological Studies Depression Scale.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fear of recurrence in patients with cancer was moderate, and the level of depression was significantly higher than that in the normal population. Fear of recurrence, invasive rumination, catastrophizing, and depression in patients with cancer were significantly positively correlated. The level of fear of recurrence was a significant positive predictor of the level of depression. Invasive rumination played a partial mediating role between fear of recurrence and depression; that is, fear of recurrence directly affected depression, and fear of recurrence indirectly affected depression through invasive rumination. Catastrophizing played a moderating role in the mediation model, in which fear of recurrence affected depression through invasive rumination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Invasive rumination plays a mediating role between fear of recurrence and depression in patients with cancer. Catastrophizing moderates the relationship between fear of recurrence and depression as well as the relationship between invasive rumination and depression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpsyt.2022.920315","type":"journal-article","created":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T01:07:26Z","timestamp":1663636046000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":23,"title":["The relationship between fear of recurrence and depression in patients with cancer: The role of invasive rumination and catastrophizing"],"prefix":"10.3389","volume":"13","author":[{"given":"Lijuan","family":"Quan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xintong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingsong","family":"Sang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,9,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.genhosppsych.2008.12.004","article-title":"Symptom indicator of severity of depression in cancer patients: A comparison of the DSM-IV criteria with alternative diagnostic criteria.","volume":"31","author":"Akechi","year":"2009","journal-title":"Gen Hosp Psychiatry."},{"key":"B2","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/S0901-5027(03)90399-1","article-title":"Fear of recurrence and possible cases of anxiety and depression in orofacial cancer patients.","volume":"32","author":"Humphris","year":"2003","journal-title":"Int J Oral Maxillofac Surg."},{"key":"B3","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0006-3223(03)00566-3","article-title":"Depression and cancer: Mechanisms and disease progression.","volume":"54","author":"Spiegel","year":"2003","journal-title":"Biol Psychiatry."},{"key":"B4","first-page":"1099","article-title":"Anxiety and depression in cancer survivors.","volume":"101","author":"Jean","year":"2017","journal-title":"Med Clin."},{"key":"B5","first-page":"27","article-title":"Quality of life and the cancer experience: The state-of-the-knowledge.","volume":"24","author":"King","year":"1997","journal-title":"Oncol Nurs Forum."},{"key":"B6","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1016\/S1470-2045(13)70244-4","article-title":"Depression and anxiety in long-term cancer survivors compared with spouses and healthy controls: A systematic review and meta-analysis.","volume":"14","author":"Mitchell","year":"2013","journal-title":"Lancet Oncol."},{"key":"B7","doi-asserted-by":"crossref","first-page":"13","DOI":"10.2190\/EUFN-RV1K-Y3TR-FK0L","article-title":"Psychosocial interventions for depression, anxiety, and quality of life in cancer survivors: Meta-analyses.","volume":"36","author":"Osborn","year":"2006","journal-title":"Int J Psychiatry Med."},{"key":"B8","doi-asserted-by":"publisher","first-page":"4072","DOI":"10.1002\/cncr.31675","article-title":"Suicide risk among cancer survivors: Head and neck versus other cancers.","volume":"124","author":"Osazuwa-Peters","year":"2018","journal-title":"Cancer."},{"key":"B9","first-page":"1","article-title":"Suicide among cancer patients.","volume":"10","author":"Zaorsky","year":"2019","journal-title":"Nat Commun."},{"key":"B10","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/j.jad.2021.05.123","article-title":"Prediction of risk of suicide death among lung cancer patients after the cancer diagnosis.","volume":"292","author":"Zhang","year":"2021","journal-title":"J Affect Disord."},{"key":"B11","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1002\/pon.4366","article-title":"Fear of new or recurrent melanoma after treatment for localised melanoma.","volume":"26","author":"Bell","year":"2017","journal-title":"Psychooncology."},{"key":"B12","doi-asserted-by":"publisher","first-page":"4207","DOI":"10.1007\/s00520-016-3248-5","article-title":"When fear of cancer recurrence becomes a clinical issue: A qualitative analysis of features associated with clinical fear of cancer recurrence.","volume":"24","author":"Mutsaers","year":"2016","journal-title":"Support. Care Cancer."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.1002\/pon.4168","article-title":"Fear of cancer recurrence: A theoretical review and its relevance for clinical presentation and management.","volume":"26","author":"Simonelli","year":"2017","journal-title":"Psychooncology."},{"key":"B14","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s11764-015-0424-4","article-title":"Screening and comorbidity of clinical levels of fear of cancer recurrence.","volume":"9","author":"Simard","year":"2015","journal-title":"J Cancer Surviv."},{"key":"B15","doi-asserted-by":"crossref","first-page":"821","DOI":"10.3109\/0284186X.2016.1150607","article-title":"Fear of cancer recurrence in prostate cancer survivors.","volume":"55","author":"Van de Wal","year":"2016","journal-title":"Acta Oncol."},{"key":"B16","article-title":"Fear of cancer recurrence inventory: Development and initial validation of a multidimensional measure of fear of cancer recurrence.","volume":"17","author":"S\u00e9bastien","year":"2009","journal-title":"Support Care Cancer."},{"key":"B17","author":"Folkman","year":"1984","journal-title":"Stress, appraisal, and coping."},{"key":"B18","doi-asserted-by":"publisher","first-page":"E26","DOI":"10.1002\/da.20409","article-title":"Negative appraisals and cognitive avoidance of intrusive memories in depression: A replication and extension.","volume":"25","author":"Williams","year":"2008","journal-title":"Depress Anxiety."},{"key":"B19","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1016\/j.janxdis.2009.05.005","article-title":"Post-trauma symptoms following indirect exposure to the September 11th terrorist attacks: The predictive role of dispositional coping.","volume":"23","author":"Baschnagel","year":"2009","journal-title":"J Anxiety Disord."},{"key":"B20","first-page":"292","article-title":"Temperament and adolescent tobacco and alcohol use: A test of interaction effects.","volume":"28","author":"Wang","year":"2012","journal-title":"Psychol Dev Educ."},{"key":"B21","doi-asserted-by":"crossref","DOI":"10.1027\/1015-5759.23.3.141","article-title":"The cognitive emotion regulation questionnaire: Psychometric features and prospective relationships with depression and anxiety in adults.","volume":"23","author":"Garnefski","year":"2007","journal-title":"Eur J Psychol Assess."},{"key":"B22","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.pec.2008.10.003","article-title":"Negative emotions in cancer care: Do oncologists\u2019 responses depend on severity and type of emotion?","volume":"76","author":"Kennifer","year":"2009","journal-title":"Patient Educ Counsel."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1002\/pon.1481","article-title":"Fear of cancer progression and cancer-related intrusive cognitions in breast cancer survivors.","volume":"18","author":"Mehnert","year":"2009","journal-title":"Psychooncology."},{"key":"B24","first-page":"1515","article-title":"Reliability and validity of Chinese version of fear of progression questionnaire-short form for cancer patients.","volume":"12","author":"Wu","year":"2015","journal-title":"Chin J Nurs."},{"key":"B25","doi-asserted-by":"crossref","DOI":"10.3724\/SP.J.1041.2014.01509","article-title":"The roles of rumination and social support in the associations between core belief challenge and post-traumatic growth among adolescent survivors after the wenchuan earthquake.","volume":"46","author":"Zhou","year":"2014","journal-title":"Acta Psychol Sin."},{"key":"B26","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1080\/10615800802573013","article-title":"The core beliefs inventory: A brief measure of disruption in the assumptive world.","volume":"23","author":"Cann","year":"2010","journal-title":"Anxiety Stress Coping."},{"key":"B27","first-page":"121","article-title":"Reliability and validity of the cognitive emotion regulation questionnaire-Chinese version.","volume":"15","author":"Zhu","year":"2007","journal-title":"Chin J Clin Psychol."},{"key":"B28","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1177\/014662167700100306","article-title":"The CES-D scale: A self-report depression scale for research in the general population.","volume":"1","author":"Radloff","year":"1977","journal-title":"Appl Psychol Meas."},{"key":"B29","first-page":"443","article-title":"Psychometric features of CES-D in Chinese adolescents.","volume":"17","author":"Chen","year":"2009","journal-title":"Chin J Clin Psychol."},{"key":"B30","first-page":"139","article-title":"Development of the Chinese age norms of CES-D in urban area.","volume":"24","author":"Zhang","year":"2010","journal-title":"Chin Ment Health J."},{"key":"B31","doi-asserted-by":"crossref","first-page":"714","DOI":"10.3724\/SP.J.1041.2014.00714","article-title":"Different methods for testing moderated mediation models: Competitors or backups?","volume":"46","author":"Wen","year":"2014","journal-title":"Acta Psychol. Sin."},{"key":"B32","author":"Hayes","year":"2012","journal-title":"Process: A Versatile Computational Tool For Observed Variable Mediation, Moderation, And Conditional Process Modeling"},{"key":"B33","first-page":"4521","article-title":"Correlation between fear of cancer recurrence and health behavior in lung cancer patients receiving ongoing chemotherapy.","volume":"44","author":"Zhao","year":"2017","journal-title":"Modern Prev Med."},{"key":"B34","doi-asserted-by":"publisher","first-page":"3824","DOI":"10.1007\/s11764-021-01118-3","article-title":"Correlation between fear of cancer recurrence and depression in patients with gastric cancer.","volume":"45","author":"Wang","year":"2018","journal-title":"Modern Prev Med."},{"key":"B35","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1002\/pon.3452","article-title":"Fear of recurrence in long \u2013 term breast cancer survivors \u2013 still an issue. Results on prevalence, determinants, and the association with quality of life and depression from the cancer survivorship \u2013 \u2013 a multi - regional population \u2013 based study.","volume":"23","author":"Koch","year":"2014","journal-title":"Psychooncology."},{"key":"B36","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/da.20228","article-title":"Rumination in posttraumatic stress disorder.","volume":"24","author":"Michael","year":"2007","journal-title":"Depress Anxiety."},{"key":"B37","doi-asserted-by":"crossref","DOI":"10.1521\/soco.1989.7.2.113","article-title":"Assumptive worlds and the stress of traumatic events: Applications of the schema construct.","volume":"7","author":"Janoff-Bulman","year":"1989","journal-title":"Social cognition"},{"key":"B38","first-page":"353","article-title":"The correlation between rumination and symptoms of anxiety and depression in patients with advanced breast cancer.","volume":"45","author":"Hu","year":"2018","journal-title":"J Int Psychiatry."},{"key":"B39","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1002\/pon.932","article-title":"Not all negative emotions are equal: The role of emotional expression in online support groups for women with breast cancer.","volume":"15","author":"Lieberman","year":"2006","journal-title":"Psychooncology."},{"key":"B40","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1200\/JCO.1997.15.2.547","article-title":"Comparison of psychologic outcome in adult survivors of childhood acute lymphoblastic leukemia versus sibling controls: A cooperative Children\u2019s Cancer Group and National Institutes of Health study.","volume":"15","author":"Zelter","year":"1997","journal-title":"J Clin Oncol."},{"key":"B41","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0191-8869(03)00083-7","article-title":"Cognitive emotion regulation strategies and depressive symptoms: Differences between males and females \u2013 sciencedirect.","volume":"36","author":"Nadia","year":"2004","journal-title":"Pers Individ Dif."},{"key":"B42","first-page":"56","article-title":"The impact of cognitive emotion regulation strategies on post-traumatic stress disorder in female patients transferred from ICU","volume":"34","author":"Han","year":"2019","journal-title":"J. Nurs. Sci."}],"container-title":["Frontiers in Psychiatry"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpsyt.2022.920315\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T01:08:14Z","timestamp":1663636094000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpsyt.2022.920315\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,20]]},"references-count":42,"alternative-id":["10.3389\/fpsyt.2022.920315"],"URL":"https:\/\/doi.org\/10.3389\/fpsyt.2022.920315","relation":{},"ISSN":["1664-0640"],"issn-type":[{"value":"1664-0640","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,20]]},"article-number":"920315"}}