{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T20:39:47Z","timestamp":1776803987210,"version":"3.51.2"},"reference-count":73,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T00:00:00Z","timestamp":1664409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Depression in adolescents is more heterogeneous and less often diagnosed than depression in adults. At present, reliable approaches to differentiating between adolescents who are and are not affected by depression are lacking. This study was designed to assess voxel-level whole-brain functional connectivity changes associated with adolescent depression in an effort to define an imaging-based biomarker associated with this condition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>In total, 71 adolescents affected by major depressive disorder (MDD) and 71 age-, sex-, and education level-matched healthy controls were subjected to resting-state functional magnetic resonance imaging (rs-fMRI) based analyses of brain voxel-wise degree centrality (DC), with a support vector machine (SVM) being used for pattern classification analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>DC patterns derived from 16-min rs-fMRI analyses were able to effectively differentiate between adolescent MDD patients and healthy controls with 95.1% accuracy (136\/143), and with respective sensitivity and specificity values of 92.1% (70\/76) and 98.5% (66\/67) based upon DC abnormalities detected in the right cerebellum. Specifically, increased DC was evident in the bilateral insula and left lingual area of MDD patients, together with reductions in the DC values in the right cerebellum and bilateral superior parietal lobe. DC values were not significantly correlated with disease severity or duration in these patients following correction for multiple comparisons.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results suggest that whole-brain network centrality abnormalities may be present in many brain regions in adolescent depression patients. Accordingly, these DC maps may hold value as candidate neuroimaging biomarkers capable of differentiating between adolescents who are and are not affected by MDD, although further validation of these results will be critical.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpsyt.2022.926292","type":"journal-article","created":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T04:37:23Z","timestamp":1664426243000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Abnormal degree centrality in first-episode medication-free adolescent depression at rest: A functional magnetic resonance imaging study and support vector machine analysis"],"prefix":"10.3389","volume":"13","author":[{"given":"Xin","family":"Guo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijun","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang","family":"Shu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanpin","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Tu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihong","family":"Bu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujun","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaohua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongchun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,9,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2383","DOI":"10.1016\/S0140-6736(16)00648-6","article-title":"Global burden of diseases, injuries, and risk factors for young people\u2019s health during 1990-2013: a systematic analysis for the global burden of disease study 2013.","volume":"387","author":"Mokdad","year":"2016","journal-title":"Lancet."},{"key":"B2","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1017\/S0033291709991036","article-title":"How common are common mental disorders? Evidence that lifetime prevalence rates are doubled by prospective versus retrospective ascertainment.","volume":"40","author":"Moffitt","year":"2010","journal-title":"Psychol Med."},{"key":"B3","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.jad.2020.02.034","article-title":"Prevalence of depressive symptoms in primary school students in China: a systematic review and meta-analysis.","volume":"268","author":"Xu","year":"2020","journal-title":"J Affect Disord."},{"key":"B4","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/j.jad.2018.08.062","article-title":"Depression literacy and stigma influence how parents perceive and respond to adolescent depressive symptoms.","volume":"241","author":"Johnco","year":"2018","journal-title":"J Affect Disord."},{"key":"B5","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1097\/00004583-199607000-00014","article-title":"Mental health service use in the community and schools: results from the four-community MECA study. Methods for the epidemiology of child and adolescent mental disorders study.","volume":"35","author":"Leaf","year":"1996","journal-title":"J Am Acad Child Adolesc Psychiatry."},{"key":"B6","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/S2215-0366(21)00479-X","article-title":"China initiates depression screening in children and adolescents.","volume":"9","author":"Kong","year":"2022","journal-title":"Lancet Psychiatry."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1016\/S0140-6736(11)60871-4","article-title":"Depression in adolescence.","volume":"379","author":"Thapar","year":"2012","journal-title":"Lancet."},{"key":"B8","doi-asserted-by":"publisher","first-page":"2299","DOI":"10.1016\/S0140-6736(18)31948-2","article-title":"Depression.","volume":"392","author":"Malhi","year":"2018","journal-title":"Lancet."},{"key":"B9","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.nicl.2013.11.009","article-title":"Functional brain imaging studies of youth depression: a systematic review.","volume":"4","author":"Kerestes","year":"2014","journal-title":"Neuroimage Clin."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1001\/jamapsychiatry.2015.1376","article-title":"Meta-analysis of functional neuroimaging of major depressive disorder in youth.","volume":"72","author":"Miller","year":"2015","journal-title":"JAMA Psychiatry."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1862","DOI":"10.1093\/cercor\/bhr269","article-title":"Network centrality in the human functional connectome.","volume":"22","author":"Zuo","year":"2012","journal-title":"Cereb Cortex."},{"key":"B12","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1111\/acps.12752","article-title":"Clinical utility of a short resting-state MRI scan in differentiating bipolar from unipolar depression.","volume":"136","author":"Li","year":"2017","journal-title":"Acta Psychiatr Scand."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1007\/s11682-020-00299-2","article-title":"Abnormal neural activities in adults and youths with major depressive disorder during emotional processing: a meta-analysis.","volume":"15","author":"Li","year":"2021","journal-title":"Brain Imaging Behav."},{"key":"B14","doi-asserted-by":"publisher","first-page":"617","DOI":"10.3389\/fnhum.2016.00617","article-title":"Decreased subcortical and increased cortical degree centrality in a nonclinical college student sample with subclinical depressive symptoms: a resting-state fMRI study.","volume":"10","author":"Gao","year":"2016","journal-title":"Front Hum Neurosci."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.2147\/NDT.S305117","article-title":"Temporal dynamics in degree centrality of brain functional connectome in first-episode schizophrenia with different short-term treatment responses: a longitudinal study.","volume":"17","author":"Wang","year":"2021","journal-title":"Neuropsychiatr Dis Treat."},{"key":"B16","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1007\/s11682-021-00505-9","article-title":"Alterations in functional network centrality in first-episode drug-naive adolescent-onset schizophrenia.","volume":"16","author":"Zhou","year":"2022","journal-title":"Brain Imaging Behav."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1002\/aur.2120","article-title":"Effects of the co-occurrence of anxiety and attention-deficit\/hyperactivity disorder on intrinsic functional network centrality among children with autism spectrum disorder.","volume":"12","author":"Wan","year":"2019","journal-title":"Autism Res."},{"key":"B18","doi-asserted-by":"publisher","first-page":"140","DOI":"10.3389\/fpsyt.2019.00140","article-title":"Abnormal degree centrality associated with cognitive dysfunctions in early bipolar disorder.","volume":"10","author":"Deng","year":"2019","journal-title":"Front Psychiatry."},{"key":"B19","doi-asserted-by":"publisher","first-page":"584","DOI":"10.4088\/JCP.15m10091","article-title":"Trait-related cortical-subcortical dissociation in bipolar disorder: analysis of network degree centrality.","volume":"78","author":"Zhou","year":"2017","journal-title":"J Clin Psychiatry."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1016\/j.neubiorev.2012.01.004","article-title":"Using support vector machine to identify imaging biomarkers of neurological and psychiatric disease: a critical review.","volume":"36","author":"Orru","year":"2012","journal-title":"Neurosci Biobehav Rev."},{"key":"B21","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1038\/s41398-020-00965-5","article-title":"Machine-learning classification using neuroimaging data in schizophrenia, autism, ultra-high risk and first-episode psychosis.","volume":"10","author":"Yassin","year":"2020","journal-title":"Transl Psychiatry."},{"key":"B22","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1186\/s12888-015-0685-5","article-title":"Distinguishing bipolar and major depressive disorders by brain structural morphometry: a pilot study.","volume":"15","author":"Fung","year":"2015","journal-title":"BMC Psychiatry."},{"key":"B23","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1016\/j.jad.2020.12.046","article-title":"Individualized identification of first-episode bipolar disorder using machine learning and cognitive tests.","volume":"282","author":"Sawalha","year":"2021","journal-title":"J Affect Disord."},{"key":"B24","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.jad.2019.03.077","article-title":"Use of machine learning in predicting clinical response to transcranial magnetic stimulation in comorbid posttraumatic stress disorder and major depression: a resting state electroencephalography study.","volume":"252","author":"Zandvakili","year":"2019","journal-title":"J Affect Disord."},{"key":"B25","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.neuroimage.2013.08.053","article-title":"Can structural MRI aid in clinical classification? A machine learning study in two independent samples of patients with schizophrenia, bipolar disorder and healthy subjects.","volume":"84","author":"Schnack","year":"2014","journal-title":"Neuroimage."},{"key":"B26","doi-asserted-by":"publisher","first-page":"e1087","DOI":"10.1038\/tp.2017.59","article-title":"Two subgroups of antipsychotic-naive, first-episode schizophrenia patients identified with a Gaussian mixture model on cognition and electrophysiology.","volume":"7","author":"Bak","year":"2017","journal-title":"Transl Psychiatry."},{"key":"B27","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1038\/s41591-020-0793-8","article-title":"A neuroimaging biomarker for striatal dysfunction in schizophrenia.","volume":"26","author":"Li","year":"2020","journal-title":"Nat Med."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1111\/cns.13048","article-title":"Machine learning in major depression: from classification to treatment outcome prediction.","volume":"24","author":"Gao","year":"2018","journal-title":"CNS Neurosci Ther."},{"key":"B29","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1162\/NECO_a_00794","article-title":"Note on support vector machines with polynomial kernels.","volume":"28","author":"Tong","year":"2016","journal-title":"Neural Comput."},{"key":"B30","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1016\/j.jad.2013.04.028","article-title":"Severity classification on the Hamilton depression rating scale.","volume":"150","author":"Zimmerman","year":"2013","journal-title":"J Affect Disord."},{"key":"B31","doi-asserted-by":"publisher","first-page":"7088856","DOI":"10.1155\/2021\/7088856","article-title":"The interaction effects of suicidal ideation and childhood abuse on brain structure and function in major depressive disorder patients.","volume":"2021","author":"Wang","year":"2021","journal-title":"Neural Plast."},{"key":"B32","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3389\/fnsys.2010.00013","article-title":"DPARSF: a MATLAB toolbox for \u201cpipeline\u201d data analysis of resting-state fMRI.","volume":"4","author":"Chao-Gan","year":"2010","journal-title":"Front Syst Neurosci."},{"key":"B33","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.neuroscience.2022.02.004","article-title":"Abnormal degree centrality as a potential imaging biomarker for right temporal lobe epilepsy: a resting-state functional magnetic resonance imaging study and support vector machine analysis.","volume":"487","author":"Gao","year":"2022","journal-title":"Neuroscience."},{"key":"B34","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1093\/schbul\/sbt050","article-title":"Diagnostic discontinuity in psychosis: a combined study of cortical gyrification and functional connectivity.","volume":"40","author":"Palaniyappan","year":"2014","journal-title":"Schizophr Bull."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1860","DOI":"10.1523\/JNEUROSCI.5062-08.2009","article-title":"Cortical hubs revealed by intrinsic functional connectivity: mapping, assessment of stability, and relation to Alzheimer\u2019s disease.","volume":"29","author":"Buckner","year":"2009","journal-title":"J Neurosci."},{"key":"B36","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.neuroimage.2015.06.058","article-title":"Degree centrality and fractional amplitude of low-frequency oscillations associated with Stroop interference.","volume":"119","author":"Takeuchi","year":"2015","journal-title":"Neuroimage."},{"key":"B37","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1080\/17470919.2017.1324521","article-title":"Evaluating methods of correcting for multiple comparisons implemented in SPM12 in social neuroscience fMRI studies: an example from moral psychology.","volume":"13","author":"Han","year":"2018","journal-title":"Soc Neurosci."},{"key":"B38","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1002\/hbm.23843","article-title":"Reproducibility of R-fMRI metrics on the impact of different strategies for multiple comparison correction and sample sizes.","volume":"39","author":"Chen","year":"2018","journal-title":"Hum Brain Mapp."},{"key":"B39","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1192\/bjpo.bp.115.002493","article-title":"Diagnostic potential of structural neuroimaging for depression from a multi-ethnic community sample.","volume":"2","author":"Sankar","year":"2016","journal-title":"BJPsych Open."},{"key":"B40","doi-asserted-by":"publisher","first-page":"4420","DOI":"10.1002\/hbm.24282","article-title":"Development and evaluation of a multimodal marker of major depressive disorder.","volume":"39","author":"Yang","year":"2018","journal-title":"Hum Brain Mapp."},{"key":"B41","doi-asserted-by":"publisher","first-page":"2059","DOI":"10.1093\/brain\/awv111","article-title":"Individualized differential diagnosis of schizophrenia and mood disorders using neuroanatomical biomarkers.","volume":"138","author":"Koutsouleris","year":"2015","journal-title":"Brain."},{"key":"B42","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1007\/s00787-013-0411-0","article-title":"Subthreshold depression in adolescence: a systematic review.","volume":"22","author":"Bertha","year":"2013","journal-title":"Eur Child Adolesc Psychiatry."},{"key":"B43","doi-asserted-by":"publisher","first-page":"634","DOI":"10.3389\/fpsyt.2018.00634","article-title":"Cerebellar contributions to major depression.","volume":"9","author":"Depping","year":"2018","journal-title":"Front Psychiatry."},{"key":"B44","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1080\/14734220701490995","article-title":"The neuropsychiatry of the cerebellum \u2013 insights from the clinic.","volume":"6","author":"Schmahmann","year":"2007","journal-title":"Cerebellum."},{"key":"B45","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1093\/brain\/awx317","article-title":"The cerebellar cognitive affective\/Schmahmann syndrome scale.","volume":"141","author":"Hoche","year":"2018","journal-title":"Brain."},{"key":"B46","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1016\/j.jad.2019.11.076","article-title":"Disrupted intrinsic functional connectivity of the cognitive control network underlies disease severity and executive dysfunction in first-episode, treatment-naive adolescent depression.","volume":"264","author":"Pan","year":"2020","journal-title":"J Affect Disord."},{"key":"B47","doi-asserted-by":"publisher","first-page":"2159","DOI":"10.1007\/s11682-020-00411-6","article-title":"Concurrent alterations of white matter microstructure and functional activities in medication-free major depressive disorder.","volume":"15","author":"Zeng","year":"2021","journal-title":"Brain Imaging Behav."},{"key":"B48","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.3389\/fpsyt.2019.01024","article-title":"Abnormal voxel-wise degree centrality in patients with late-life depression: a resting-state functional magnetic resonance imaging study.","volume":"10","author":"Li","year":"2019","journal-title":"Front Psychiatry."},{"key":"B49","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1186\/s12888-016-1047-7","article-title":"Association between abnormal default mode network activity and suicidality in depressed adolescents.","volume":"16","author":"Zhang","year":"2016","journal-title":"BMC Psychiatry."},{"key":"B50","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1002\/hbm.22626","article-title":"Convergent functional architecture of the superior parietal lobule unraveled with multimodal neuroimaging approaches.","volume":"36","author":"Wang","year":"2015","journal-title":"Hum Brain Mapp."},{"key":"B51","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1093\/cercor\/bhaa250","article-title":"Superior parietal lobule: a role in relative localization of multiple different elements.","volume":"31","author":"Vialatte","year":"2021","journal-title":"Cereb Cortex."},{"key":"B52","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1038\/mp.2016.60","article-title":"Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA major depressive disorder working group.","volume":"22","author":"Schmaal","year":"2017","journal-title":"Mol Psychiatry."},{"key":"B53","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1001\/archgenpsychiatry.2011.36","article-title":"Distinguishing between major depressive disorder and obsessive-compulsive disorder in children by measuring regional cortical thickness.","volume":"68","author":"Fallucca","year":"2011","journal-title":"Arch Gen Psychiatry."},{"key":"B54","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.jpsychires.2022.01.038","article-title":"Altered regional brain activity and functional connectivity patterns in major depressive disorder: a function of childhood trauma or diagnosis?","volume":"147","author":"Luo","year":"2022","journal-title":"J Psychiatr Res."},{"key":"B55","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.nicl.2015.11.021","article-title":"Transdiagnostic commonalities and differences in resting state functional connectivity of the default mode network in schizophrenia and major depression.","volume":"10","author":"Schilbach","year":"2016","journal-title":"Neuroimage Clin."},{"key":"B56","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1111\/j.1469-7610.2008.01972.x","article-title":"Reduced activation in lateral prefrontal cortex and anterior cingulate during attention and cognitive control functions in medication-naive adolescents with depression compared to controls.","volume":"50","author":"Halari","year":"2009","journal-title":"J Child Psychol Psychiatry."},{"key":"B57","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.bbr.2012.12.031","article-title":"Selective role of lingual\/parahippocampal gyrus and retrosplenial complex in spatial memory across viewpoint changes relative to the environmental reference frame.","volume":"242","author":"Sulpizio","year":"2013","journal-title":"Behav Brain Res."},{"key":"B58","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/(SICI)1097-0193(1998)6:5\/6<383::AID-HBM10>3.0.CO;2-Z","article-title":"ERP and fMRI measures of visual spatial selective attention.","volume":"6","author":"Mangun","year":"1998","journal-title":"Hum Brain Mapp."},{"key":"B59","doi-asserted-by":"publisher","first-page":"10456","DOI":"10.1073\/pnas.96.18.10456","article-title":"Linguistic threat activates the human amygdala.","volume":"96","author":"Isenberg","year":"1999","journal-title":"Proc Natl Acad Sci U.S.A."},{"key":"B60","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.jad.2014.08.018","article-title":"Impact of lingual gyrus volume on antidepressant response and neurocognitive functions in major depressive disorder: a voxel-based morphometry study.","volume":"169","author":"Jung","year":"2014","journal-title":"J Affect Disord."},{"key":"B61","doi-asserted-by":"publisher","first-page":"323","DOI":"10.3389\/fnhum.2012.00323","article-title":"Major depressive disorder and alterations in insular cortical activity: a review of current functional magnetic imaging research.","volume":"6","author":"Sliz","year":"2012","journal-title":"Front Hum Neurosci."},{"key":"B62","doi-asserted-by":"publisher","first-page":"101204","DOI":"10.1016\/j.eclinm.2021.101204","article-title":"Brain structural associations with depression in a large early adolescent sample (the ABCD study(R)).","volume":"42","author":"Shen","year":"2021","journal-title":"EClinicalMedicine."},{"key":"B63","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/j.ebiom.2018.09.010","article-title":"Abnormal amygdala resting-state functional connectivity in adults and adolescents with major depressive disorder: a comparative meta-analysis.","volume":"36","author":"Tang","year":"2018","journal-title":"EBiomedicine."},{"key":"B64","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1038\/sj.mp.4001919","article-title":"Fronto-limbic brain structures in suicidal and non-suicidal female patients with major depressive disorder.","volume":"12","author":"Monkul","year":"2007","journal-title":"Mol Psychiatry."},{"key":"B65","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.neulet.2011.08.017","article-title":"A preliminary study of the dysregulation of the resting networks in first-episode medication-naive adolescent depression.","volume":"503","author":"Jin","year":"2011","journal-title":"Neurosci Lett."},{"key":"B66","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1016\/j.biopsych.2013.05.036","article-title":"Resting-state functional connectivity of subgenual anterior cingulate cortex in depressed adolescents.","volume":"74","author":"Connolly","year":"2013","journal-title":"Biol Psychiatry."},{"key":"B67","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.jad.2015.03.012","article-title":"Altered insular activation and increased insular functional connectivity during sad and happy face processing in adolescent major depressive disorder.","volume":"178","author":"Henje","year":"2015","journal-title":"J Affect Disord."},{"key":"B68","doi-asserted-by":"publisher","first-page":"e25159","DOI":"10.1371\/journal.pone.0025159","article-title":"Increased activity imbalance in fronto-subcortical circuits in adolescents with major depression.","volume":"6","author":"Jiao","year":"2011","journal-title":"PLoS One."},{"key":"B69","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.neulet.2009.05.022","article-title":"A preliminary study of functional connectivity in comorbid adolescent depression.","volume":"460","author":"Cullen","year":"2009","journal-title":"Neurosci Lett."},{"key":"B70","doi-asserted-by":"crossref","first-page":"e13472","DOI":"10.1111\/psyp.13472","article-title":"PTSD and its dissociative subtype through the lens of the insula: anterior and posterior insula resting-state functional connectivity and its predictive validity using machine learning.","volume":"57","author":"Harricharan","year":"2020","journal-title":"Psychophysiology."},{"key":"B71","doi-asserted-by":"publisher","first-page":"2972","DOI":"10.1002\/hbm.24053","article-title":"Anterior insula hyperactivation in ADHD when faced with distracting negative stimuli.","volume":"39","author":"Vetter","year":"2018","journal-title":"Hum Brain Mapp."},{"key":"B72","doi-asserted-by":"publisher","first-page":"e591","DOI":"10.1038\/tp.2015.84","article-title":"Increased anterior insula activity in anxious individuals is linked to diminished perceived control.","volume":"5","author":"Alvarez","year":"2015","journal-title":"Transl Psychiatry."},{"key":"B73","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.jad.2007.01.027","article-title":"History of illness prior to a diagnosis of bipolar disorder or schizoaffective disorder.","volume":"103","author":"Berk","year":"2007","journal-title":"J Affect Disord."}],"container-title":["Frontiers in Psychiatry"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpsyt.2022.926292\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T04:37:29Z","timestamp":1664426249000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpsyt.2022.926292\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,29]]},"references-count":73,"alternative-id":["10.3389\/fpsyt.2022.926292"],"URL":"https:\/\/doi.org\/10.3389\/fpsyt.2022.926292","relation":{},"ISSN":["1664-0640"],"issn-type":[{"value":"1664-0640","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,29]]},"article-number":"926292"}}