{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:56:36Z","timestamp":1788396996448,"version":"build-2803163510"},"reference-count":72,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T00:00:00Z","timestamp":1656374400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:p>Premenstrual syndrome (PMS) is a group of psychological, physical, and behavioral symptoms that recur with the menstrual cycle, usually occurring a few days before menstruation and ceasing with the onset of menstruation. Premenstrual dysphoric disorder (PMDD) is a severe form of PMS that has been included in a subcategory of depression in the Diagnostic and Statistical Manual of Mental Disorders (DSM-V) according to the latest diagnostic criteria. Patients usually present with mild to moderate emotional and physical symptoms that affect their routine work, social activities, and family lives. The pathogenesis of PMDD remains unclear, and some researchers believe that it is related to fluctuations in ovarian hormone levels. However, the details of the interrelationships and regulating effects between ovarian hormones, symptoms, and the brain need to be more comprehensively determined. Recent studies have revealed some novel findings on PMS and PMDD based on brain morphology, function, and metabolism. Additionally, multiple studies have suggested that PMS and PMDD are closely related to brain structural and functional variations in certain core temporal lobe regions, such as the amygdala and hippocampus. We summarized neuroimaging studies of PMS and PMDD related to the temporal lobe by retrospectively reviewing relevant literature over the past decade. This review contributes to further clarifying the significant role of the temporal lobe in PMS and PMDD and understanding the neurochemical links between hormones, symptoms, and the brain.<\/jats:p>","DOI":"10.3389\/fpsyt.2022.954211","type":"journal-article","created":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T07:58:03Z","timestamp":1656403083000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["The Prominent Role of the Temporal Lobe in Premenstrual Syndrome and Premenstrual Dysphoric Disorder: Evidence From Multimodal Neuroimaging"],"prefix":"10.3389","volume":"13","author":[{"given":"Jingyi","family":"Long","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuejie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianzhong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,6,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/7854_2018_70","article-title":"The sexual differentiation of the human brain: role of sex hormones vs. sex chromosomes","volume":"43","author":"Bakker","year":"2019","journal-title":"Curr Top Behav Neurosci."},{"key":"B2","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1016\/j.jad.2018.12.133","article-title":"Neural correlates of depression in women across the reproductive lifespan\u2014an fmri review","volume":"246","author":"Stickel","year":"2019","journal-title":"J Affect Disord."},{"key":"B3","doi-asserted-by":"publisher","first-page":"719241","DOI":"10.3389\/fpsyt.2021.719241","article-title":"Comorbid premenstrual dysphoric disorder and bipolar disorder: a review","volume":"12","author":"Slyepchenko","year":"2021","journal-title":"Front Psychiatry."},{"key":"B4","year":"2013"},{"key":"B5","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1007\/s00737-010-0165-3","article-title":"Prevalence and predictors of premenstrual syndrome and premenstrual dysphoric disorder in a population-based sample","volume":"13","author":"Tschudin","year":"2010","journal-title":"Arch Womens Ment Health."},{"key":"B6","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/j.maturitas.2015.08.010","article-title":"Premenstrual syndrome: a mini review","volume":"82","author":"Ryu","year":"2015","journal-title":"Maturitas."},{"key":"B7","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/1472-6874-14-52","article-title":"Prevalence, impacts and medical managements of premenstrual syndrome among female students: cross-sectional study in college of health sciences, Mekelle university, Mekelle, Northern Ethiopia","volume":"14","author":"Tolossa","year":"2014","journal-title":"BMC Womens Health."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0306-4530(03)00098-2","article-title":"The prevalence, impairment, impact, and burden of Premenstrual dysphoric disorder (Pms\/Pmdd)","volume":"28","author":"Halbreich","year":"2003","journal-title":"Psychoneuroendocrinology."},{"key":"B9","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.ejogrb.2012.01.017","article-title":"Prevalence of premenstrual syndrome and premenstrual dysphoric disorder in a population-based sample in China","volume":"162","author":"Qiao","year":"2012","journal-title":"Eur J Obstet Gynecol Reprod Biol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/j.mcna.2019.02.007","article-title":"Premenstrual dysphoric disorder","volume":"103","author":"Lanza di Scalea","year":"2019","journal-title":"Med Clin North Am"},{"key":"B11","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1176\/appi.ajp.2012.11081302","article-title":"Premenstrual dysphoric disorder: evidence for a new category for Dsm-5","volume":"169","author":"Epperson","year":"2012","journal-title":"Am J Psychiatry."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.1017\/S0033291717003270","article-title":"Brain activation during emotion regulation in women with premenstrual dysphoric disorder","volume":"48","author":"Petersen","year":"2018","journal-title":"Psychol Med."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1089\/jwh.1.1999.8.1043","article-title":"The impact of premenstrual symptomatology on functioning and treatment-seeking behavior: experience from the United States, United Kingdom, and France","volume":"8","author":"Hylan","year":"1999","journal-title":"J Women's Health Gend-Based Med."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1176\/ajp.155.9.1234","article-title":"Longitudinal population-based twin study of retrospectively reported premenstrual symptoms and lifetime major depression","volume":"155","author":"Kendler","year":"1998","journal-title":"Am J Psychiatry."},{"key":"B15","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1017\/S0033291701004901","article-title":"Genetic and environmental influences on premenstrual symptoms in an Australian twin sample","volume":"32","author":"Treloar","year":"2002","journal-title":"Psychol Med."},{"key":"B16","doi-asserted-by":"publisher","first-page":"596128","DOI":"10.3389\/fpubh.2021.596128","article-title":"Trends in research related to premenstrual syndrome and premenstrual dysphoric disorder from 1945 to 2018: a bibliometric analysis","volume":"9","author":"Gao","year":"2021","journal-title":"Front Public Health."},{"key":"B17","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1017\/S0033291701004925","article-title":"Prevalence, incidence and stability of premenstrual dysphoric disorder in the community","volume":"32","author":"Wittchen","year":"2002","journal-title":"Psychol Med."},{"key":"B18","volume-title":"Diagnostic and Statistical Manual of Mental Disorders: Dsm-V.","author":"Francesmonneris","year":"2013"},{"key":"B19","doi-asserted-by":"publisher","first-page":"100878","DOI":"10.1016\/j.yfrne.2020.100878","article-title":"Neuroimaging the menstrual cycle: a multimodal systematic review","volume":"60","author":"Dubol","year":"2021","journal-title":"Front Neuroendocrinol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.psyneuen.2014.07.025","article-title":"Emotional and cognitive functional imaging of estrogen and progesterone effects in the female human brain: a systematic review","volume":"50","author":"Toffoletto","year":"2014","journal-title":"Psychoneuroendocrinology."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1867","DOI":"10.1038\/s41386-019-0435-3","article-title":"The cycling brain: menstrual cycle related fluctuations in hippocampal and fronto-striatal activation and connectivity during cognitive tasks","volume":"44","author":"Pletzer","year":"2019","journal-title":"Neuropsychopharmacology."},{"key":"B22","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1038\/npp.2017.157","article-title":"Hormonal cycle and contraceptive effects on amygdala and salience resting-state networks in women with previous affective side effects on the pill","volume":"43","author":"Engman","year":"2018","journal-title":"Neuropsychopharmacology."},{"key":"B23","doi-asserted-by":"publisher","first-page":"32833","DOI":"10.1038\/srep32833","article-title":"In-Vivo dynamics of the human hippocampus across the menstrual cycle.","volume":"6","author":"Barth","year":"2016","journal-title":"Sci Rep."},{"key":"B24","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.neuroimage.2015.06.012","article-title":"Hippocampal volume and functional connectivity changes during the female menstrual cycle","volume":"118","author":"Lisofsky","year":"2015","journal-title":"Neuroimage."},{"key":"B25","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.nlm.2014.01.017","article-title":"Menstrual-cycle dependent fluctuations in ovarian hormones affect emotional memory","volume":"110","author":"Bayer","year":"2014","journal-title":"Neurobiol Learn Mem."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1002\/hbm.21502","article-title":"Menstrual cycle-related changes in amygdala morphology are associated with changes in stress sensitivity","volume":"34","author":"Ossewaarde","year":"2013","journal-title":"Hum Brain Mapp."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1900","DOI":"10.1007\/s00330-017-5206-0","article-title":"Larger volume and different functional connectivity of the amygdala in women with premenstrual syndrome","volume":"28","author":"Deng","year":"2018","journal-title":"Eur Radiol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.jad.2018.04.046","article-title":"Cortical and subcortical changes in patients with premenstrual syndrome","volume":"235","author":"Liu","year":"2018","journal-title":"J Affect Disord."},{"key":"B29","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.jad.2017.04.045","article-title":"Altered fractional amplitude of low frequency fluctuation in premenstrual syndrome: a resting state fmri study","volume":"218","author":"Liao","year":"2017","journal-title":"J Affect Disord."},{"key":"B30","doi-asserted-by":"publisher","first-page":"e0136029","DOI":"10.1371\/journal.pone.0136029","article-title":"Abnormal resting-state connectivity at functional mri in women with premenstrual syndrome","volume":"10","author":"Liu","year":"2015","journal-title":"PLoS ONE."},{"key":"B31","doi-asserted-by":"publisher","first-page":"44","DOI":"10.3389\/fnins.2015.00044","article-title":"Progesterone mediates brain functional connectivity changes during the menstrual cycle-a pilot resting state mri study","volume":"9","author":"Ar\u00e9lin","year":"2015","journal-title":"Front Neurosci."},{"key":"B32","doi-asserted-by":"publisher","first-page":"19529","DOI":"10.18632\/aging.203363","article-title":"Brain reactivity to emotional stimuli in women with premenstrual dysphoric disorder and related personality characteristics","volume":"13","author":"Gao","year":"2021","journal-title":"Aging."},{"key":"B33","doi-asserted-by":"publisher","first-page":"104782","DOI":"10.1016\/j.yhbeh.2020.104782","article-title":"Trait-related changes in brain network topology in premenstrual dysphoric disorder","volume":"124","author":"Dan","year":"2020","journal-title":"Horm Behav."},{"key":"B34","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1038\/s41398-019-0670-8","article-title":"Resting-state functional connectivity in women with Pmdd","volume":"9","author":"Petersen","year":"2019","journal-title":"Transl Psychiatry."},{"key":"B35","doi-asserted-by":"publisher","first-page":"301","DOI":"10.3389\/fpsyt.2017.00301","article-title":"Brain structure and function in women with comorbid bipolar and premenstrual dysphoric disorder","volume":"8","author":"Syan","year":"2017","journal-title":"Front Psychiatry."},{"key":"B36","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/2045-5380-4-3","article-title":"Social stimulation and corticolimbic reactivity in premenstrual dysphoric disorder: a preliminary study","volume":"4","author":"Gingnell","year":"2014","journal-title":"Biol Mood Anxiety Disord."},{"key":"B37","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.jad.2012.02.010","article-title":"Gray matter abnormalities in patients with premenstrual dysphoric disorder: an optimized voxel-based morphometry","volume":"140","author":"Jeong","year":"2012","journal-title":"J Affect Disord."},{"key":"B38","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1016\/j.yhbeh.2012.07.005","article-title":"Menstrual cycle effects on amygdala reactivity to emotional stimulation in premenstrual dysphoric disorder","volume":"62","author":"Gingnell","year":"2012","journal-title":"Horm Behav."},{"key":"B39","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1146\/annurev.neuro.27.070203.144130","article-title":"The medial temporal lobe","volume":"27","author":"Squire","year":"2004","journal-title":"Annu Rev Neurosci."},{"key":"B40","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.psyneuen.2018.09.032","article-title":"Sex differences during emotion processing are dependent on the menstrual cycle phase","volume":"100","author":"Dan","year":"2019","journal-title":"Psychoneuroendocrinology."},{"key":"B41","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1038\/sj.mp.4002030","article-title":"Progesterone selectively increases amygdala reactivity in women","volume":"13","author":"van Wingen","year":"2008","journal-title":"Mol Psychiatry."},{"key":"B42","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1038\/nature09820","article-title":"Amygdala circuitry mediating reversible and bidirectional control of anxiety","volume":"471","author":"Tye","year":"2011","journal-title":"Nature."},{"key":"B43","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.tics.2017.03.002","article-title":"A network model of the emotional brain","volume":"21","author":"Pessoa","year":"2017","journal-title":"Trends Cogn Sci."},{"key":"B44","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1002\/hbm.22199","article-title":"The human amygdala and pain: evidence from neuroimaging","volume":"35","author":"Simons","year":"2014","journal-title":"Hum Brain Mapp."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1476","DOI":"10.1176\/appi.ajp.2007.07030504","article-title":"Functional neuroimaging of anxiety: a meta-analysis of emotional processing in ptsd, social anxiety disorder, and specific phobia","volume":"164","author":"Etkin","year":"2007","journal-title":"Am J Psychiatry."},{"key":"B46","doi-asserted-by":"publisher","first-page":"e43","DOI":"10.1016\/j.biopsych.2010.09.041","article-title":"Localization of dysfunction in major depressive disorder: prefrontal cortex and amygdala","volume":"69","author":"Murray","year":"2011","journal-title":"Biol Psychiatry."},{"key":"B47","doi-asserted-by":"publisher","first-page":"1326","DOI":"10.1093\/brain\/awf137","article-title":"Painful stimuli evoke different stimulus-response functions in the amygdala, prefrontal, insula and somatosensory cortex: a single-trial fmri study","volume":"125","author":"Bornh\u00f6vd","year":"2002","journal-title":"Brain"},{"key":"B48","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/s11920-015-0619-4","article-title":"Neuroimaging the menstrual cycle and premenstrual dysphoric disorder","volume":"17","author":"Comasco","year":"2015","journal-title":"Curr Psychiatry Rep."},{"key":"B49","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.jad.2007.09.015","article-title":"Toward a functional neuroanatomy of premenstrual dysphoric disorder","volume":"108","author":"Protopopescu","year":"2008","journal-title":"J Affect Disord."},{"key":"B50","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1002\/jnr.23809","article-title":"Understanding the broad influence of sex hormones and sex differences in the brain","volume":"95","author":"McEwen","year":"2017","journal-title":"J Neurosci Res."},{"key":"B51","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.psyneuen.2015.04.022","article-title":"Estradiol levels modulate brain activity and negative responses to psychosocial stress across the menstrual cycle","volume":"59","author":"Albert","year":"2015","journal-title":"Psychoneuroendocrinology."},{"key":"B52","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1002\/hipo.20468","article-title":"Hippocampal structural changes across the menstrual cycle","volume":"18","author":"Protopopescu","year":"2008","journal-title":"Hippocampus."},{"key":"B53","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.neuroimage.2003.08.037","article-title":"Estrogen- and tamoxifen-associated effects on brain structure and function","volume":"21","author":"Eberling","year":"2004","journal-title":"Neuroimage."},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0272-17.2017","article-title":"The progestin receptor interactome in the female mouse hypothalamus: interactions with synaptic proteins are isoform specific and ligand dependent","author":"Acharya","year":"2017","journal-title":"eNeuro"},{"key":"B55","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1080\/09540261.2017.1397607","article-title":"Using positron emission tomography to investigate hormone-mediated neurochemical changes across the female lifespan: implications for depression","volume":"29","author":"Zsido","year":"2017","journal-title":"Int Rev Psychiatry."},{"key":"B56","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.yhbeh.2015.06.010","article-title":"Estrogen receptors in the central nervous system and their implication for dopamine-dependent cognition in females","volume":"74","author":"Almey","year":"2015","journal-title":"Horm Behav."},{"key":"B57","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.pnpbp.2014.05.009","article-title":"Estrogenic mediation of serotonergic and neurotrophic systems: implications for female mood disorders","volume":"54","author":"Borrow","year":"2014","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry."},{"key":"B58","doi-asserted-by":"publisher","first-page":"24357","DOI":"10.18632\/aging.202249","article-title":"A forced swim-based rat model of premenstrual depression: effects of hormonal changes and drug intervention","volume":"12","author":"Wei","year":"2020","journal-title":"Aging."},{"key":"B59","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.yfrne.2008.02.001","article-title":"Progesterone receptors: form and function in brain","volume":"29","author":"Brinton","year":"2008","journal-title":"Front Neuroendocrinol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"62","DOI":"10.3389\/fnhum.2017.00062","article-title":"Abnormal spontaneous brain activity in women with premenstrual syndrome revealed by regional homogeneity","volume":"11","author":"Liao","year":"2017","journal-title":"Front Hum Neurosci."},{"key":"B61","doi-asserted-by":"publisher","first-page":"2465","DOI":"10.1073\/pnas.0605569104","article-title":"Menstrual cycle phase modulates reward-related neural function in women","volume":"104","author":"Dreher","year":"2007","journal-title":"Proc Natl Acad Sci U S A."},{"key":"B62","doi-asserted-by":"publisher","first-page":"11416","DOI":"10.1523\/JNEUROSCI.1715-07.2007","article-title":"How progesterone impairs memory for biologically salient stimuli in healthy young women","volume":"27","author":"van Wingen","year":"2007","journal-title":"J Neurosci."},{"key":"B63","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1152\/physrev.00044.2020","article-title":"How development sculpts hippocampal circuits and function","volume":"102","author":"Cossart","year":"2022","journal-title":"Physiol Rev."},{"key":"B64","doi-asserted-by":"publisher","first-page":"697","DOI":"10.3389\/fpsyt.2018.00697","article-title":"Abnormal default mode network homogeneity in treatment-naive patients with first-episode depression","volume":"9","author":"Gao","year":"2018","journal-title":"Front Psychiatry."},{"key":"B65","doi-asserted-by":"publisher","first-page":"751400","DOI":"10.3389\/fneur.2021.751400","article-title":"Abnormal fractional amplitude of low-frequency fluctuation as a potential imaging biomarker for first-episode major depressive disorder: a resting-state fmri study and support vector machine analysis","volume":"12","author":"Gao","year":"2021","journal-title":"Front Neurol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"117091","DOI":"10.1016\/j.neuroimage.2020.117091","article-title":"Functional reorganization of brain networks across the human menstrual cycle","volume":"220","author":"Pritschet","year":"2020","journal-title":"Neuroimage."},{"key":"B67","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1007\/s00429-019-02019-z","article-title":"Human menstrual cycle variation in subcortical functional brain connectivity: a multimodal analysis approach","volume":"225","author":"Hidalgo-Lopez","year":"2020","journal-title":"Brain Struct Funct."},{"key":"B68","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1017\/S0033291714002001","article-title":"Functional brain-imaging correlates of negative affectivity and the onset of first-episode depression","volume":"45","author":"Davey","year":"2015","journal-title":"Psychol Med."},{"key":"B69","doi-asserted-by":"publisher","first-page":"E67","DOI":"10.1503\/jpn.210143","article-title":"White matter microstructure and volume correlates of premenstrual dysphoric disorder","volume":"47","author":"Gu","year":"2022","journal-title":"J Psychiatry Neurosci."},{"key":"B70","doi-asserted-by":"publisher","first-page":"4450","DOI":"10.1002\/hbm.22486","article-title":"Emotional fronto-cingulate cortex activation and brain derived neurotrophic factor polymorphism in premenstrual dysphoric disorder","volume":"35","author":"Comasco","year":"2014","journal-title":"Hum Brain Mapp."},{"key":"B71","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/s11920-015-0628-3","article-title":"Premenstrual dysphoric disorder: epidemiology and treatment","volume":"17","author":"Hantsoo","year":"2015","journal-title":"Curr Psychiatry Rep."},{"key":"B72","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1159\/000507083","article-title":"Shaping of the female human brain by sex hormones: a review","volume":"111","author":"Rehbein","year":"2021","journal-title":"Neuroendocrinology."}],"container-title":["Frontiers in Psychiatry"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpsyt.2022.954211\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T07:58:07Z","timestamp":1656403087000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpsyt.2022.954211\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,28]]},"references-count":72,"alternative-id":["10.3389\/fpsyt.2022.954211"],"URL":"https:\/\/doi.org\/10.3389\/fpsyt.2022.954211","relation":{},"ISSN":["1664-0640"],"issn-type":[{"value":"1664-0640","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,28]]},"article-number":"954211"}}