{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T17:40:18Z","timestamp":1788198018208,"version":"build-2803163510"},"reference-count":49,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T00:00:00Z","timestamp":1668038400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Growing evidence supports that alterations in the gut microbiota play an essential role in the etiology of anxiety, depression, and other psychiatric disorders. However, the potential effect of oral microbiota on mental health has received little attention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using the latest genome-wide association study (GWAS) summary data of the oral microbiome, polygenic risk scores (PRSs) of 285 salivary microbiomes and 309 tongue dorsum microbiomes were conducted. Logistic and linear regression models were applied to evaluate the relationship between salivary-tongue dorsum microbiome interactions with anxiety and depression. Two-sample Mendelian randomization (MR) was utilized to compute the causal effects between the oral microbiome, anxiety, and depression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We observed significant salivary-tongue dorsum microbiome interactions related to anxiety and depression traits. Significantly, one common interaction was observed to be associated with both anxiety score and depression score, <jats:italic>Centipeda periodontii SGB 224<\/jats:italic>  \u00d7 <jats:italic>Granulicatella uSGB 3289<\/jats:italic> (P <jats:sub>depressionscore<\/jats:sub> = 1.41 \u00d7 10<jats:sup>\u22128<\/jats:sup>, P <jats:sub>anxietyscore<\/jats:sub> = 5.10 \u00d7 10<jats:sup>\u22128<\/jats:sup>). Furthermore, we detected causal effects between the oral microbiome and anxiety and depression. Importantly, we identified one salivary microbiome associated with both anxiety and depression in both the UKB database and the Finngen public database, <jats:italic>Eggerthia<\/jats:italic> (P <jats:sub>IVW \u2212 majordepression \u2212 UKB<\/jats:sub> = 2.99 \u00d7 10<jats:sup>\u22126<\/jats:sup>, P <jats:sub>IVW \u2212 Self \u2212 reportedanxiety\/panicattacks \u2212 UKB<\/jats:sub> = 3.06 \u00d7 10<jats:sup>\u221259<\/jats:sup>, P <jats:sub>IVW \u2212 depression \u2212 Finngen<\/jats:sub> = 3.16 \u00d7 10<jats:inline-formula><mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:msubsup><mml:mrow\/><mml:mrow><mml:mo>,<\/mml:mo><\/mml:mrow><mml:mrow><mml:mo>-<\/mml:mo><mml:mn>16<\/mml:mn><\/mml:mrow><\/mml:msubsup><\/mml:math><\/jats:inline-formula> P <jats:sub>IVW \u2212 anxiety \u2212 Finngen<\/jats:sub> = 1.14 \u00d7 10<jats:sup>\u2212115<\/jats:sup>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study systematically explored the relationship between the oral microbiome and anxiety and depression, which could help improve our understanding of disease pathogenesis and propose new diagnostic targets and early intervention strategies.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpsyt.2022.960756","type":"journal-article","created":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T08:13:35Z","timestamp":1668068015000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":29,"title":["A genetic association study reveals the relationship between the oral microbiome and anxiety and depression 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