{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:14:41Z","timestamp":1790734481382,"version":"4.1.0"},"reference-count":58,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T00:00:00Z","timestamp":1660780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>In patients with anorexia nervosa (AN), gastrointestinal (GI) symptoms are common and usually improve during or after nutritional rehabilitation. It is unclear when exactly GI symptoms change in the timecourse of treatment and to which extent. In this study, we analyzed the timecourse of GI symptoms and their relation to disease-specific, demographic, anthropometric, and psychological factors in inpatients with AN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In weekly intervals, the Gastrointestinal Symptom Rating Scale (GSRS) was completed, and body weight was measured over a mean of 9.5 weeks in inpatients with AN. A total of four self-report questionnaires assessing psychological factors were completed before and after inpatient treatment. Data from 38 inpatients with AN were analyzed using mixed linear models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Abdominal pain and constipation improved significantly in the timecourse with 0.085 (<jats:italic>p<\/jats:italic> = 0.002) and 0.101 (<jats:italic>p<\/jats:italic> = 0.004) points per week on the GSRS and were predicted to normalize after 13 (<jats:italic>p<\/jats:italic> = 0.002) and 17 (<jats:italic>p<\/jats:italic> = 0.004) weeks, respectively. Total GI symptoms tended to normalize after 25 weeks (<jats:italic>p<\/jats:italic> = 0.079). Indigestion (borborygmus, abdominal distension, eructation, flatulence) was the most severely pathological symptom at admission and did not improve significantly (<jats:italic>p<\/jats:italic> = 0.197). Diarrhea and reflux were, on average, not pathological at admission and remained stable during treatment. In addition to treatment time, the strongest predictors were ED pathology at admission for the development of abdominal pain, constipation, reflux, and total GI symptoms; stress for the development of constipation and total GI symptoms; and depression for constipation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Informing patients with AN about the course of GI symptoms and their improvement during weight rehabilitation may help support compliance during treatment.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpsyt.2022.962837","type":"journal-article","created":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T05:32:54Z","timestamp":1660800774000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Gastrointestinal complaints in patients with anorexia nervosa in the timecourse of inpatient treatment"],"prefix":"10.3389","volume":"13","author":[{"given":"Caroline","family":"Riedlinger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazar","family":"Mazurak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Sch\u00e4ffeler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Stengel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin Elisabeth","family":"Giel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Zipfel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Enck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Mack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,8,18]]},"reference":[{"key":"B1","year":"2013","journal-title":"Diagnostic and Statistical Manual of Mental Disorders."},{"key":"B2","year":"2019","journal-title":"International Classification of Diseases for Mortality and Morbidity Statistics."},{"key":"B3","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1146\/annurev.med.51.1.299","article-title":"Anorexia and bulimia nervosa.","volume":"51","author":"Kaye","year":"2000","journal-title":"Annu Rev Med."},{"key":"B4","first-page":"S25","article-title":"Subacute ruminal acidosis (SARA) challenge, ruminal condition and cellular immunity in cattle.","volume":"63","author":"Sato","year":"2015","journal-title":"Jpn J Vet Res."},{"key":"B5","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.eatbeh.2006.11.010","article-title":"When energy in does not equal energy out: disordered energy control.","volume":"8","author":"Abraham","year":"2007","journal-title":"Eat Behav."},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2020.00195","article-title":"Which symptoms, complaints and complications of the gastrointestinal tract occur in patients with eating disorders? 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