{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:27:07Z","timestamp":1787027227084,"version":"build-2736575974"},"reference-count":38,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T00:00:00Z","timestamp":1665014400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>People with epilepsy (PWE) have a higher prevalence of psychiatric disorders. Some individuals with drug-resistant epilepsy might benefit from surgical interventions. The aim of this study was to perform an assessment of psychiatric comorbidities with a follow-up period of 12 months in patients with drug-resistant epilepsy, comparing those who underwent surgery to those who did not.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>We assessed psychiatric comorbidities at baseline, after 4 months and after 12 months. Psychiatric symptoms and diagnoses were assessed using SCID-Interview, Hamilton Rating Scale for Depression, Beck-Depression Inventory, Hamilton Anxiety Rating Scale, Prodromal-Questionnaire and the Global Assessment of Functioning Scale.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty-five patients were included in the study, 12 underwent surgery, 11 were esteemed as being neurologically unqualified for surgery and two refused surgery. Patients in the no-surgery group were significantly older, reported more substance use, had significantly higher levels of anxiety and were more often diagnosed with a personality disorder. Age and levels of anxiety were significant predictors of being in the surgery or the no-surgery group. The described differences between surgery and no-surgery patients did not change significantly over the follow-up period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>These data point toward a higher expression of baseline psychiatric symptoms in drug-resistant PWE without surgery. Further studies are warranted to further elucidate these findings and to clarify potential psychotropic effects of epilepsy itself, drug-resistant epilepsy and of epilepsy surgery and their impact on psychopathology. Clinically, it seems highly relevant to include psychiatrists in an interdisciplinary state-of-the-art perioperative management of drug-resistant PWE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpsyt.2022.966721","type":"journal-article","created":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T09:34:40Z","timestamp":1665048880000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Psychiatric symptoms and comorbidities in patients with drug-resistant epilepsy in presurgical assessment\u2014A prospective explorative single center study"],"prefix":"10.3389","volume":"13","author":[{"given":"Fabian","family":"Friedrich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina","family":"Pataraia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Aull-Watschinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Zehetmayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisbeth","family":"Weitensfelder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Watschinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilufar","family":"Mossaheb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,10,6]]},"reference":[{"key":"B1","year":"2011"},{"key":"B2","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1159\/000107563","article-title":"Increased 12-month prevalence rates of mental disorders in patients with chronic somatic disease","volume":"76","author":"H\u00e4rter","year":"2007","journal-title":"Psychother Psychosom."},{"key":"B3","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.jad.2007.01.015","article-title":"Depression\u2013anxiety relationships with chronic physical conditions: results from the World Mental Health surveys","volume":"103","author":"Scott","year":"2007","journal-title":"J Affect Disord."},{"key":"B4","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1097\/YCO.0b013e328303ba42","article-title":"Comorbid mental and somatic disorders: an epidemiological perspective","volume":"21","author":"Iacovides","year":"2008","journal-title":"Curr Opin Psychiatry."},{"key":"B5","doi-asserted-by":"publisher","first-page":"7","DOI":"10.31887\/DCNS.2011.13.1\/wkaton","article-title":"Epidemiology and treatment of depression in patients with chronic medical illness","volume":"13","author":"Katon","year":"2011","journal-title":"Dialogues Clin Neurosci."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1756","DOI":"10.1136\/heartjnl-2019-316379","article-title":"Mental disorders and cardiovascular disease: what should we be looking out for?","volume":"107","author":"Michal","year":"2021","journal-title":"Heart."},{"key":"B7","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.genhosppsych.2010.01.013","article-title":"Comorbidity between common mental disorders and chronic somatic diseases in primary care patients","volume":"32","author":"Gili","year":"2010","journal-title":"Gen Hosp Psychiatry."},{"key":"B8","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1016\/S0140-6736(07)61415-9","article-title":"Depression, chronic diseases, and decrements in health: results from the World Health Surveys","volume":"370","author":"Moussavi","year":"2007","journal-title":"Lancet."},{"key":"B9","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/S0140-6736(18)32596-0","article-title":"O'Brien T, Sander JW. 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