{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T08:13:55Z","timestamp":1779351235796,"version":"3.51.4"},"reference-count":60,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T00:00:00Z","timestamp":1669248000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Assessing the role of oxytocin (OT) in the regulation of social interaction is a promising area that opens up new opportunities for studying the mechanisms of developing autism spectrum disorders (ASD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the correlation between the salivary OT level and age-related and psychopathological symptoms of children with intellectual disability (ID) and ASD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used the clinical and psychopathological method to assess the signs of ASD based on International Classification of Diseases (ICD-10), the severity of ASD was specified by the selected Russian type version \u201cChildhood Autism Rating Scale\u201d (CARS). Patients of both groups had an IQ score below 70 points.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median and interquartile range of salivary OT levels in patients with ID and ASD were 23.897 [14.260\u201359.643] pg\/mL, and in the group ID without ASD - Me = 50.896 [33.502\u201383.774] pg\/mL (<jats:italic>p<\/jats:italic> = 0.001). The severity of ASD on the CARS scale Me = 51.5 [40.75\u201356.0] score in the group ID with ASD, and in the group ID without ASD\u2014at the level of Me = 32 [27.0\u201338.0] points (<jats:italic>p<\/jats:italic> &amp;lt; 0.001). According to the results of correlation-regression analysis in the main group, a direct correlation was established between salivary OT level and a high degree of severity of ASD Rho = 0.435 (<jats:italic>p<\/jats:italic> = 0.005). There was no correlation between the salivary OT level and intellectual development in the group ID with ASD, Rho = 0.013 (<jats:italic>p<\/jats:italic> = 0.941) and we have found a relationship between oxytocin and intellectual development in the group ID without ASD, Rho = 0.297 (<jats:italic>p<\/jats:italic> = 0.005). There was no correlation between salivary OT and age, ASD and age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results of this study indicate that patients in the group ID with ASD demonstrated a lower level of salivary OT concentration and a direct relationship between the maximum values of this indicator and the severity of autistic disorders, in contrast to patients in the group ID without ASD.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpsyt.2022.969674","type":"journal-article","created":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T06:09:35Z","timestamp":1669270175000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Salivary oxytocin in autistic patients and in patients with intellectual disability"],"prefix":"10.3389","volume":"13","author":[{"given":"Yulia 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