{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T04:03:25Z","timestamp":1778126605032,"version":"3.51.4"},"reference-count":51,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T00:00:00Z","timestamp":1658880000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:p>While abnormal neuroimaging features have been reported in patients suffering from right temporal lobe epilepsy (rTLE), the value of altered degree centrality (DC) as a diagnostic biomarker for rTLE has yet to be established. As such, the present study was designed to examine DC abnormalities in rTLE patients in order to gauge the diagnostic utility of these neuroimaging features. In total, 68 patients with rTLE and 73 healthy controls (HCs) participated in this study. Imaging data were analyzed using DC and receiver operating characteristic (ROC) methods. Ultimately, rTLE patients were found to exhibit reduced right caudate DC and increased left middle temporal gyrus, superior parietal gyrus, superior frontal gyrus, right precuneus, frontal gyrus Inferior gyrus, middle-superior frontal gyrus, and inferior parietal gyrus DC relative to HC. ROC analyses indicated that DC values in the right caudate nucleus could be used to differentiate between rTLE patients and HCs with a high degree of sensitivity and specificity. Together, these results thus suggest that rTLE is associated with abnormal DC values in the right caudate nucleus, underscoring the relevance of further studies of the underlying pathophysiology of this debilitating condition.<\/jats:p>","DOI":"10.3389\/fpsyt.2022.981728","type":"journal-article","created":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T04:46:06Z","timestamp":1658897166000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Abnormal hubs in global network as neuroimaging biomarker in right temporal lobe epilepsy at rest"],"prefix":"10.3389","volume":"13","author":[{"given":"Ruimin","family":"Guo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunfei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Honghua","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jihua","family":"Jian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haibo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengxi","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongwei","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,7,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"775781","DOI":"10.3389\/fneur.2021.775781","article-title":"Temporal lobe epilepsy and psychiatric comorbidity.","volume":"12","author":"Vinti","year":"2021","journal-title":"Front Neurol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1001\/archneur.1964.00460150003001","article-title":"Etiology and pathogenesis of temporal lobe epilepsy.","volume":"10","author":"Falconer","year":"1964","journal-title":"Arch Neurol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"2390","DOI":"10.1002\/hbm.24530","article-title":"Structural and functional asymmetry of medial temporal subregions in unilateral temporal lobe epilepsy: a 7T MRI study.","volume":"40","author":"Shah","year":"2019","journal-title":"Hum Brain Mapp."},{"key":"B4","doi-asserted-by":"publisher","first-page":"112044","DOI":"10.1016\/j.bbr.2019.112044","article-title":"Impairments in cognitive functions and emotional and social behaviors in a rat lithium-pilocarpine model of temporal lobe epilepsy.","volume":"372","author":"Smolensky","year":"2019","journal-title":"Behav Brain Res."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1001\/jamaneurol.2019.1708","article-title":"Progressive cortical thinning in patients with focal epilepsy.","volume":"76","author":"Galovic","year":"2019","journal-title":"JAMA Neurol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1097\/WNP.0000000000000572","article-title":"The role of EEG in the erroneous diagnosis of epilepsy.","volume":"36","author":"Amin","year":"2019","journal-title":"J Clin Neurophysiol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"e11239","DOI":"10.1097\/MD.0000000000011239","article-title":"Abnormal default-mode network homogeneity in patients with temporal lobe epilepsy.","volume":"97","author":"Gao","year":"2018","journal-title":"Medicine."},{"key":"B8","doi-asserted-by":"publisher","first-page":"e0134","DOI":"10.1097\/MD.0000000000010134","article-title":"Decreased functional connectivity and structural deficit in alertness network with right-sided temporal lobe epilepsy.","volume":"97","author":"Gao","year":"2018","journal-title":"Medicine."},{"key":"B9","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.neuroscience.2022.02.004","article-title":"Abnormal degree centrality as a potential imaging biomarker for right temporal lobe epilepsy: a resting-state functional magnetic resonance imaging study and support vector machine analysis.","volume":"487","author":"Gao","year":"2022","journal-title":"Neuroscience."},{"key":"B10","doi-asserted-by":"publisher","first-page":"108153","DOI":"10.1016\/j.yebeh.2021.108153","article-title":"Blood oxygen level-dependent (BOLD) response patterns with thalamic deep brain stimulation in patients with medically refractory epilepsy.","volume":"122","author":"Sarica","year":"2021","journal-title":"Epilepsy Behav."},{"key":"B11","doi-asserted-by":"publisher","first-page":"101759","DOI":"10.1016\/j.nicl.2019.101759","article-title":"BOLD-fMRI activity informed by network variation of scalp EEG in juvenile myoclonic epilepsy.","volume":"22","author":"Qin","year":"2019","journal-title":"NeuroImage Clin."},{"key":"B12","doi-asserted-by":"publisher","first-page":"3197","DOI":"10.1016\/j.clinph.2021.07.028","article-title":"Individual localization value of resting-state fMRI in epilepsy presurgical evaluation: a combined study with stereo-EEG.","volume":"132","author":"Tang","year":"2021","journal-title":"Clin Neurophysiol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"2785","DOI":"10.1111\/epi.16731","article-title":"Seven-tesla quantitative magnetic resonance spectroscopy of glutamate, \u03b3-aminobutyric acid, and glutathione in the posterior cingulate cortex\/precuneus in patients with epilepsy.","volume":"61","author":"Gonen","year":"2020","journal-title":"Epilepsia."},{"key":"B14","doi-asserted-by":"publisher","first-page":"107278","DOI":"10.1016\/j.yebeh.2020.107278","article-title":"Aberrant dorsal attention network homogeneity in patients with right temporal lobe epilepsy.","volume":"111","author":"Zhou","year":"2020","journal-title":"Epilepsy Behav."},{"key":"B15","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1111\/cns.13449","article-title":"Altered amplitude of low-frequency fluctuations and regional homogeneity in drug-resistant epilepsy patients with vagal nerve stimulators under different current intensity.","volume":"27","author":"Zhu","year":"2021","journal-title":"CNS Neurosci Ther."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.3389\/fneur.2018.01038","article-title":"Multimodal data and machine learning for detecting specific biomarkers in pediatric epilepsy patients with generalized tonic-clonic seizures.","volume":"9","author":"Wang","year":"2018","journal-title":"Front Neurol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"220","DOI":"10.3390\/ijms20010220","article-title":"Neuroimaging biomarkers of experimental epileptogenesis and refractory epilepsy.","volume":"20","author":"Reddy","year":"2019","journal-title":"Int J Mol Sci."},{"key":"B18","doi-asserted-by":"publisher","first-page":"e0256601","DOI":"10.1371\/journal.pone.0256601","article-title":"Network centrality for the identification of biomarkers in respondent-driven sampling datasets.","volume":"16","author":"Grubb","year":"2021","journal-title":"PLoS One."},{"key":"B19","doi-asserted-by":"publisher","first-page":"3178","DOI":"10.4103\/0366-6999.170269","article-title":"Abnormal degree centrality of bilateral putamen and left superior frontal gyrus in schizophrenia with auditory hallucinations: a resting-state functional magnetic resonance imaging study.","volume":"128","author":"Chen","year":"2015","journal-title":"Chine Med J."},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs-525264\/v1","author":"Li","year":"2021","journal-title":"Altered Brain Network Degree Centrality in Major Depressive Disorder via Electro-Acupuncture Stimulation at Baihui (GV20)."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.3390\/brainsci11111534","article-title":"Aberrant amplitude of low-frequency fluctuation and degree centrality within the default mode network in patients with vascular mild cognitive impairment.","volume":"11","author":"Li","year":"2021","journal-title":"Brain Sci."},{"key":"B22","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.jocn.2021.07.016","article-title":"Graph-theory based degree centrality combined with machine learning algorithms can predict response to treatment with antiepileptic medications in children with epilepsy.","volume":"91","author":"Wang","year":"2021","journal-title":"J Clin Neurosci."},{"key":"B23","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1089\/brain.2014.0244","article-title":"Save the global: global signal connectivity as a tool for studying clinical populations with functional magnetic resonance imaging.","volume":"4","author":"Hahamy","year":"2014","journal-title":"Brain Connect."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s42600-022-00222-2","article-title":"Detection of major depressive disorder, bipolar disorder, schizophrenia and generalized anxiety disorder using vocal acoustic analysis and machine learning: an exploratory study.","author":"Wanderley Espinola","year":"2022","journal-title":"Res Biomed Eng."},{"key":"B25","doi-asserted-by":"publisher","first-page":"e0255529","DOI":"10.1371\/journal.pone.0255529","article-title":"EEG p-adic quantum potential accurately identifies depression, schizophrenia and cognitive decline.","volume":"16","author":"Shor","year":"2021","journal-title":"PLoS One."},{"key":"B26","doi-asserted-by":"publisher","first-page":"4457","DOI":"10.3390\/molecules26154457","article-title":"Characterization of potential protein biomarkers for major depressive disorder using matrix-assisted laser desorption ionization\/time-of-flight mass spectrometry.","volume":"26","author":"Lin","year":"2021","journal-title":"Molecules."},{"key":"B27","doi-asserted-by":"publisher","first-page":"07TR01","DOI":"10.1088\/1361-6560\/aab4b1","article-title":"Receiver operating characteristic (ROC) curves: review of methods with applications in diagnostic medicine.","volume":"63","author":"Obuchowski","year":"2018","journal-title":"Phys Med Biol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"e56694","DOI":"10.7554\/eLife.56694","article-title":"The caudate nucleus contributes causally to decisions that balance reward and uncertain visual information.","volume":"9","author":"Doi","year":"2020","journal-title":"eLife."},{"key":"B29","doi-asserted-by":"publisher","first-page":"2930","DOI":"10.1093\/brain\/awz254","article-title":"Caudate stimulation enhances learning.","volume":"142","author":"Bick","year":"2019","journal-title":"Brain."},{"key":"B30","article-title":"Neuroanatomy, nucleus caudate.","author":"Driscoll","year":"2021","journal-title":"StatPearls [Internet]"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs-638717\/v1","author":"Jiang","year":"2021","journal-title":"ML of Striatum rs-fMRI Features Predicts TLE Diagnosis."},{"key":"B32","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1111\/cns.13462","article-title":"Deep brain stimulation of the anterior nuclei of the thalamus relieves basal ganglia dysfunction in monkeys with temporal lobe epilepsy.","volume":"27","author":"Du","year":"2021","journal-title":"CNS Neurosci Ther."},{"key":"B33","doi-asserted-by":"crossref","first-page":"p. 525","DOI":"10.4324\/9781315791272-31","article-title":"The frontal lobe.","author":"Faglioni","year":"2020","journal-title":"Handbook of Clinical and Experimental Neuropsychology."},{"key":"B34","doi-asserted-by":"publisher","first-page":"107172","DOI":"10.1016\/j.yebeh.2020.107172","article-title":"Neuroticism in temporal lobe epilepsy is associated with altered limbic-frontal lobe resting-state functional connectivity.","volume":"110","author":"Bonet","year":"2020","journal-title":"Epilepsy Behav."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1111\/epi.16528","article-title":"Cognitive phenotypes in temporal lobe epilepsy utilizing data-and clinically driven approaches: moving toward a new taxonomy.","volume":"61","author":"Reyes","year":"2020","journal-title":"Epilepsia."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1384","DOI":"10.3389\/fneur.2019.01384","article-title":"A functional MRI paradigm suitable for language and memory mapping in pediatric temporal lobe epilepsy.","volume":"10","author":"Buck","year":"2020","journal-title":"Front Neurol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.sleep.2020.12.016","article-title":"Sleep profile and polysomnography in patients with drug-resistant temporal lobe epilepsy (TLE) due to hippocampal sclerosis (HS) and the effect of epilepsy surgery on sleep-a prospective cohort study.","volume":"80","author":"Yaranagula","year":"2021","journal-title":"Sleep Med."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1136\/jnnp-2017-317783","article-title":"Systematic review and network meta-analysis of resective surgery for mesial temporal lobe epilepsy.","volume":"89","author":"Jain","year":"2018","journal-title":"J Neurol Neurosurg Psychiatry."},{"key":"B39","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/B978-0-444-63622-5.00017-6","article-title":"Limb apraxia and the left parietal lobe.","volume":"151","author":"Buxbaum","year":"2018","journal-title":"Handb Clin Neurol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/B978-0-444-63622-5.00018-8","article-title":"The parietal lobe and language.","volume":"151","author":"Coslett","year":"2018","journal-title":"Handb Clin Neurol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/B978-0-444-63622-5.00028-0","article-title":"The mirror mechanism in the parietal lobe.","volume":"151","author":"Rizzolatti","year":"2018","journal-title":"Handb Clin Neurol."},{"key":"B42","first-page":"1","article-title":"The default mode network in patient with temporal lobe epilepsy (TLE) : a resting state fMRI study.","volume":"4","author":"Husbani","year":"2020","journal-title":"Asian J Med Biomed."},{"key":"B43","doi-asserted-by":"crossref","first-page":"23","DOI":"10.37231\/ajmb.2020.4.1.326","article-title":"The default mode network in patient with temporal lobe epilepsy (TLE) : a resting state fMRI study.","volume":"4","author":"Shuhada","year":"2020","journal-title":"Asian J Med Biomed."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41378-019-0124-8","article-title":"Thermal scanning probe lithography\u2014a review.","volume":"6","author":"Howell","year":"2020","journal-title":"Microsyst Nanoeng."},{"key":"B45","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1093\/brain\/awl004","article-title":"The precuneus: a review of its functional anatomy and behavioural correlates.","volume":"129","author":"Cavanna","year":"2006","journal-title":"Brain."},{"key":"B46","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.jns.2018.01.010","article-title":"Altered spontaneous brain activity in MRI-negative refractory temporal lobe epilepsy patients with major depressive disorder: a resting-state fMRI study.","volume":"386","author":"Zhu","year":"2018","journal-title":"J Neurol Sci."},{"key":"B47","doi-asserted-by":"crossref","DOI":"10.1088\/1757-899X\/785\/1\/012047","article-title":"Evaluation of default mode network in temporal lobe epilepsy patients and healthy subjects: a preliminary result.","author":"Shuhada","year":"2020","journal-title":"Proceedings of the IOP Conference Series: Materials Science and Engineering."},{"key":"B48","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.yebeh.2019.02.031","article-title":"Default mode network deactivation in pediatric temporal lobe epilepsy: relationship to a working memory task and executive function tests.","volume":"94","author":"Oyegbile","year":"2019","journal-title":"Epilepsy Behav."},{"key":"B49","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1111\/ane.13379","article-title":"Abnormal blood oxygen level-dependent fluctuations and remote connectivity in sleep-related hypermotor epilepsy.","volume":"143","author":"Liu","year":"2021","journal-title":"Acta Neurol Scand."},{"key":"B50","doi-asserted-by":"publisher","first-page":"108336","DOI":"10.1016\/j.yebeh.2021.108336","article-title":"Resting-state functional connectivity in the idiopathic generalized epilepsies: a systematic review and meta-analysis of EEG and MEG studies.","volume":"124","author":"Dharan","year":"2021","journal-title":"Epilepsy Behav."},{"key":"B51","doi-asserted-by":"publisher","first-page":"245","DOI":"10.3174\/ajnr.A5944","article-title":"Alterations in brain metabolites in patients with epilepsy with impaired consciousness: a case-control study of interictal multivoxel 1H-MRS findings.","volume":"40","author":"Tan","year":"2019","journal-title":"Am J Neuroradiol."}],"container-title":["Frontiers in Psychiatry"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpsyt.2022.981728\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T04:46:16Z","timestamp":1658897176000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpsyt.2022.981728\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,27]]},"references-count":51,"alternative-id":["10.3389\/fpsyt.2022.981728"],"URL":"https:\/\/doi.org\/10.3389\/fpsyt.2022.981728","relation":{},"ISSN":["1664-0640"],"issn-type":[{"value":"1664-0640","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,27]]},"article-number":"981728"}}