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Psychiatry"],"abstract":"<jats:p>Buprenorphine, which has been approved for the treatment of opioid dependence, reduces cocaine consumption by co-activating \u03bc-opioid receptors and nociceptin\/orphanin FQ peptide (NOP) receptors. However, the role of buprenorphine in methamphetamine (METH) reinforcement and drug-seeking behavior remains unclear. This study investigated the effects of buprenorphine on METH self-administration and reinstatement of METH-seeking behavior in rats. We found that buprenorphine pretreatment had an inhibitory effect on METH self-administration behavior, and that buprenorphine at a dose of 0.3 mg\/kg could inhibit motivation to respond for METH. Pretreatment with the NOP receptor antagonist thienorphine (0.5 mg\/kg) or SB-612111 (1 mg\/kg) could reverse the inhibitory effect of buprenorphine (0.1 mg\/kg) on the METH self-administration. Moreover, treatment with buprenorphine (0.1 mg\/kg and 0.3 mg\/kg) significantly reduced the drug-seeking behavior induced by context or by METH priming but failed to reduce the drug-seeking behavior induced by conditional cues. Additionally, the NOP receptor antagonist SB-612111 reversed the inhibitory action of buprenorphine on the drug-seeking behavior induced by METH priming. The results demonstrated that buprenorphine reduced either METH intake or the drug-seeking behavior by activating NOP receptors, providing empirical evidence for the clinical use of buprenorphine in the treatment of METH relapse and addiction.<\/jats:p>","DOI":"10.3389\/fpsyt.2022.983595","type":"journal-article","created":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T06:48:35Z","timestamp":1665038915000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Buprenorphine reduces methamphetamine intake and drug seeking behavior via activating nociceptin\/orphanin FQ peptide receptor in 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