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In this study, we aimed to explore the cause of stress and fear of coronavirus-19 (COVID-19) among Chinese college students in Wuhan during the latest strictest lockdown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>During the COVID-19 outbreak, 1,070 college students from Wuhan, aged 18\u201329 years, took part in an online survey. We used correlations, bootstrap tests, and other statistical analysis methods to analyze the data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Negative coping style significantly positively predicted fear of COVID-19, and stress had a significant mediating effect on the relationship between negative coping style and fear of COVID-19. In addition, rumination and stress had a chain-mediating effect on the relationship between negative coping style and fear of COVID-19. Perceived social support moderated the three paths of this serial mediation model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Negative emotions, such as stress and fear of COVID-19, in college students are caused by both behavior (e.g., negative coping style) and cognition (e.g., rumination). Importantly, negative cognitive thinking (i.e., rumination) is often a malign consequence of a negative coping style. Thus, to improve students' mental health, students should be encouraged to engage in more positive behaviors and seek social support during periods of adherence to regular prevention and control measures.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpsyt.2022.994685","type":"journal-article","created":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T08:50:57Z","timestamp":1669279857000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Relationship between negative coping style and fear of COVID-19 among Wuhan college students during the post-pandemic period: A moderated chain mediation model"],"prefix":"10.3389","volume":"13","author":[{"given":"Lei","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziyun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,11,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"157","DOI":"10.23750\/abm.v91i1.9397","article-title":"Who declares covid-19 a pandemic","volume":"91","author":"Cucinotta","year":"2020","journal-title":"Acta Bio Medica Atenei Parmensis."},{"journal-title":"Who Director-General's Opening Remarks at the Media Briefing on Covid19\u221211 March 2020","year":"","key":"B2"},{"key":"B3","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1016\/S0140-6736(20)30460-8","article-title":"The psychological impact of quarantine and how to reduce it: rapid review of the evidence","volume":"395","author":"Brooks","year":"2020","journal-title":"Lancet."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.16128\/j.cnki.1005-3611.2021.06.043","article-title":"The influence of social support on anxiety among university students during covid-19 control phase: the chain mediating roles of self-esteem and resilience","volume":"29","author":"Shu","year":"2021","journal-title":"Chinese J Clin Psychol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"916776","DOI":"10.3389\/fpsyg.2022.916776","article-title":"Exploring the necessity of psychological rounds and psychological interventions in general hospitals in the post-covid-19 period","volume":"13","author":"Tang","year":"2022","journal-title":"Front Psychol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"7493","DOI":"10.1007\/s12144-020-01318-7","article-title":"Coping strategies of individuals in the united kingdom during the covid-19 pandemic","author":"Ogueji","year":"2021","journal-title":"Curr Psychol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1177\/0020764020961790","article-title":"Coping styles and mental health in response to societal changes during the covid-19 pandemic","volume":"67","author":"Gurvich","year":"2020","journal-title":"Int J Soc Psychiatr."},{"key":"B8","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1186\/s40359-021-00603-9","article-title":"How have people been coping during the covid-19 pandemic? 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