{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:27:09Z","timestamp":1753892829305,"version":"3.41.2"},"reference-count":44,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T00:00:00Z","timestamp":1677542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the severity of menopausal symptoms and the correlation among different quality of life questionnaires and compare the quality of life of patients who underwent hematopoietic stem cell transplantation (HSCT) for hematological disorders with the norm group in order to facilitate personalized and directed therapeutic intervention for patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We recruited women who had premature ovarian failure (POF) after HSCT for hematologic diseases in the gynecological endocrinology outpatient clinic of Peking University People's Hospital. Women with HSCT were included in the study if they had 6 months of spontaneous amenorrhea with serum follicle-stimulating hormone levels greater than 40 mIU\/mL taken 4 weeks apart. The patients who had other causes of POF were excluded. During the survey, all women were required to fill out the questionnaires [Quality of Life Questionnaire (MENQOL), Generalized Anxiety Disorder-7 (GAD-7), Patient Health Questionnaire-9 (PHQ-9), and 36-item Short-Form (SF-36)] online. We analyzed the severity of menopausal symptoms, anxiety, and depression in Participants. In addition, differences on the SF-36 scale scores between the study group and norm groups were examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 227 (93.41%) patients completed the survey and were analyzed. The severity of all symptoms is \u201cnone and mild\u201d in MRS, MENQOL, GAD-7, and PHQ-9. On the MRS, the most common symptoms were irritability, physical and mental exhaustion, and sleep problems. The severest symptoms were sexual problems (53, 73.82%), followed by sleep problems (44, 19.38%) and mental and physical exhaustion (39, 17.18%). In the MENQOL, the most common symptoms were psychosocial and physical symptoms. The severest symptoms were sexual symptoms (35, 48.75%) followed by psychosocial symptoms (23, 10.13%). Moderate-severe scores were shown in 11.89% (27) and 18.72% (42) cases in the GAD-7 and PHQ-9, respectively. Based on SF-36, in comparison with the norm group, the HSCT participants had higher vitality scores and lower role physical, physical functioning, and role emotional scores aged 18\u201345. In addition, the HSCT participants had lower mental health scores aged 18\u201325, and lower general health scores aged 25\u201345. No strong correlation was observed between questionnaires in our study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Overall, menopausal symptoms are milder in female patients after HSCT. There is no single scale that comprehensively assesses the patient's quality of life after HSCT. We need to assess the severity of various symptoms in patients using different scales.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpsyt.2023.1050959","type":"journal-article","created":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T16:59:04Z","timestamp":1678121944000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Menopausal symptoms and quality of life in female survivors treated with hematopoietic stem cell transplantation"],"prefix":"10.3389","volume":"14","author":[{"given":"Huina","family":"Su","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiling","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaohua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,2,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1038\/bmt.2015.228","article-title":"Childhood to adult transition and long-term follow-up after blood and marrow transplantation","volume":"51","author":"Cupit","year":"2016","journal-title":"Bone Marrow Transplant"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.1038\/s41409-021-01227-8","article-title":"Hematopoietic cell transplantation and cellular therapy survey of the EBMT: monitoring of activities and trends over 30 years","volume":"56","author":"Passweg","year":"2021","journal-title":"Bone Marrow Transplant"},{"key":"B3","doi-asserted-by":"publisher","first-page":"2940","DOI":"10.1038\/s41409-021-01431-6","article-title":"Hematopoietic stem cell transplantation activity in China 2019: a report from the Chinese Blood and Marrow Transplantation Registry Group","volume":"56","author":"Xu","year":"2021","journal-title":"Bone Marrow Transpl."},{"key":"B4","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1038\/bmt.2013.211","article-title":"Clinical guide to fertility preservation in hematopoietic cell transplant recipients","volume":"49","author":"Joshi","year":"2014","journal-title":"Bone Marrow Transpl."},{"key":"B5","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1080\/09513590500099255","article-title":"Function of the hypothalamic\u2013pituitary\u2013gonadal axis in long-term survivors of hematopoietic stem cell transplantation for hematological diseases","volume":"21","author":"Somali","year":"2005","journal-title":"Gynecol Endocrinol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"956867","DOI":"10.3389\/fmed.2022.956867","article-title":"Gynecological complications in long-term survivors after allogeneic hematopoietic cell transplantation-a single-center real-life cross-sectional study","volume":"9","author":"Su","year":"2022","journal-title":"Front Med"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.1016\/j.bbmt.2009.07.019","article-title":"Receiving information on fertility- and menopause-related treatment effects among women who undergo hematopoietic stem cell transplantation: changes in perceived importance over time","volume":"15","author":"Nakayama","year":"2009","journal-title":"Biol Blood Marrow Transplant"},{"key":"B8","first-page":"231","article-title":"Anxiety and depression in patients with acute leukaemia treated with hematopoietic stem cell transplantation","volume":"31","author":"Warchala","year":"2019","journal-title":"Psychiatr Danubina."},{"key":"B9","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1080\/07347330902978947","article-title":"Do coping and social support predict depression and anxiety in patients undergoing hematopoietic stem cell transplantation?","volume":"27","author":"Wells","year":"2009","journal-title":"J Psychosoc Oncol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"751","DOI":"10.30773\/pi.2019.07.12","article-title":"Anxiety and depression of the patients with hematological malignancies during hospitalization for hematopoietic stem cell transplantation. 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