{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:20:51Z","timestamp":1791174051448,"version":"4.1.0"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T00:00:00Z","timestamp":1685059200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The purpose of this study is to investigate the shared and distinct thalamic-cortical circuit between bipolar depression and remission, as well as to investigate the trait and state-related characteristics of the abnormal thalamic-cortical circuit in bipolar disorder.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Resting-state functional magnetic resonance imaging was performed on 38 bipolar depression patients, 40 bipolar remission patients, and 39 gender-matched healthy controls (rsfMRI). The thalamic subregions were used as seed points to draw the functional connectivity of the entire brain, and then the shared and distinct thalamic-cortical circuits between bipolar depression and remission were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>When compared to the healthy group, both groups of patients had significantly lower functional connectivity between the rostral temporal thalamus and the lingual gyrus, the posterior parietal thalamus, the precuneus\/cerebellum, and the occipital thalamus and the precuneus; however, functional connectivity between the premotor thalamus and the superior medial frontal was significantly lower in depression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study discovered that both bipolar depression and remission had abnormal sensorimotor-thalamic functional connectivity, implying that it is a trait-related characteristic of bipolar disorder; however, the decline in prefrontal-thalamic connectivity exists specifically in bipolar depression, implying that it is a state-related characteristic of bipolar disorder.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpsyt.2023.1067819","type":"journal-article","created":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T04:23:26Z","timestamp":1685075006000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Trait and state-related characteristics of thalamo-cortical circuit disruption in bipolar disorder: a prospective cross-sectional study"],"prefix":"10.3389","volume":"14","author":[{"given":"Can","family":"Zeng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SuQun","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidan","family":"Pu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,5,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1016\/S0140-6736(13)60989-7","article-title":"Bipolar disorder diagnosis: challenges and future directions","volume":"381","author":"Phillips","year":"2013","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"102742","DOI":"10.1016\/j.ebiom.2020.102742","article-title":"Large-scale network dysfunction in the acute state compared to the remitted state of bipolar disorder: a meta-analysis of resting-state functional connectivity","volume":"54","author":"Wang","year":"2020","journal-title":"EBioMedicine"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/j.jad.2013.05.083","article-title":"A systematic literature review of resting state network\u2014functional MRI in bipolar disorder","volume":"150","author":"Vargas","year":"2013","journal-title":"J Affect Disord"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"e01953","DOI":"10.1002\/brb3.1953","article-title":"Altered functional activity in bipolar disorder: a comprehensive review from a large-scale network perspective","volume":"11","author":"Yoon","year":"2021","journal-title":"Brain Behav"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1016\/j.neuroimage.2011.07.054","article-title":"Normal amygdala activation but deficient ventrolateral prefrontal activation in adults with bipolar disorder during euthymia","volume":"59","author":"Foland-Ross","year":"2012","journal-title":"NeuroImage"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"2995","DOI":"10.1002\/hbm.22380","article-title":"Amygdala excitability to subliminally presented emotional faces distinguishes unipolar and bipolar depression: an fMRI and pattern classification study","volume":"35","author":"Grotegerd","year":"2014","journal-title":"Hum Brain Mapp"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/j.biopsych.2013.04.024","article-title":"Is aberrant functional connectivity a psychosis Endophenotype? 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