{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T15:59:52Z","timestamp":1776959992854,"version":"3.51.4"},"reference-count":50,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T00:00:00Z","timestamp":1682467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The purpose of this paper is to provide a mini-review covering the recent progress in human and animal studies on local field potentials (LFPs) of major depressive disorder (MDD) and obsessive-compulsive disorder (OCD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>PubMed and EMBASE were searched to identify related studies. Inclusion criteria were (1) reported the LFPs on OCD or MDD, (2) published in English, and (3) human or animal studies. Exclusion criteria were (1) review or meta-analysis or other literature types without original data and (2) conference abstract without full text. Descriptive synthesis of data was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eight studies on LFPs of OCD containing 22 patients and 32 rats were included: seven were observational studies with no controls, and one animal study included a randomized and controlled phase. Ten studies on LFPs of MDD containing 71 patients and 52 rats were included: seven were observational studies with no controls, one study with control, and two animal studies included a randomized and controlled phase.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The available studies revealed that different frequency bands were associated with specific symptoms. Low frequency activity seemed to be closely related to OCD symptoms, whereas LFPs findings in patients with MDD were more complicated. However, limitations of recent studies restrict the drawing of definite conclusions. Combined with other measures such as Electroencephalogram, Electrocorticography, or Magnetoencephalography and long-term recordings in various physiological states (rest state, sleep state, task state) could help to improve the understanding of potential mechanisms.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpsyt.2023.1080260","type":"journal-article","created":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T05:21:56Z","timestamp":1682486516000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Local field potentials in major depressive and obsessive-compulsive disorder: a frequency-based review"],"prefix":"10.3389","volume":"14","author":[{"given":"Wei","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Botao","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linglong","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,4,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"2299","DOI":"10.1016\/S0140-6736(18)31948-2","article-title":"Depression","volume":"392","author":"Malhi","year":"2018","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1002\/da.22217","article-title":"Major depressive disorder in DSM-5: implications for clinical practice and research of changes from DSM-IV","volume":"31","author":"Uher","year":"2014","journal-title":"Depress Anxiety"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1146\/annurev-publhealth-031912-114409","article-title":"The epidemiology of depression across cultures","volume":"34","author":"Kessler","year":"2013","journal-title":"Annu Rev Public Health"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.tics.2011.11.003","article-title":"Obsessive-compulsive disorder: beyond segregated cortico-striatal pathways","volume":"16","author":"Milad","year":"2012","journal-title":"Trends Cogn Sci"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"102746","DOI":"10.1016\/j.nicl.2021.102746","article-title":"Performance monitoring in obsessive\u2013compulsive disorder: insights from internal capsule\/nucleus accumbens deep brain stimulation","volume":"31","author":"Sch\u00fcller","year":"2021","journal-title":"NeuroImage Clin"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/mp.2008.94","article-title":"The epidemiology of obsessive-compulsive disorder in the National Comorbidity Survey Replication","volume":"15","author":"Ruscio","year":"2010","journal-title":"Mol Psychiatry"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/j.psc.2006.02.013","article-title":"Pharmacotherapy of obsessive-compulsive disorder and obsessive-compulsive spectrum disorders","volume":"29","author":"Denys","year":"2006","journal-title":"Psychiatr Clin North Am"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.1016\/S0140-6736(99)02376-4","article-title":"Electrical stimulation in anterior limbs of internal capsules in patients with obsessive-compulsive disorder","volume":"354","author":"Nuttin","year":"1999","journal-title":"Lancet"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/j.neuron.2005.02.014","article-title":"Deep brain stimulation for treatment-resistant depression","volume":"45","author":"Mayberg","year":"2005","journal-title":"Neuron"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"101","DOI":"10.3389\/fncir.2016.00101","article-title":"Local field potentials: myths and misunderstandings","volume":"10","author":"Herreras","year":"2016","journal-title":"Front Neural Circuits"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1038\/nrn3241","article-title":"The origin of extracellular fields and currents--EEG, ECoG, LFP and spikes","volume":"13","author":"Buzsaki","year":"2012","journal-title":"Nat Rev Neurosci"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1152\/jn.01095.2002","article-title":"What determines the frequency of fast network oscillations with irregular neural discharges? 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