{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T12:27:25Z","timestamp":1782476845057,"version":"3.54.5"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T00:00:00Z","timestamp":1674777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:p>We describe the case of a patient diagnosed with Huntington's disease (HD), who, following a two-year history of anxiety with obsessional preoccupations, developed psychosis with clinical lycanthropy: a prominent delusional idea that he was a werewolf. Although there was no benefit from various antidepressants and antipsychotics, there was remarkable improvement of his symptoms following prescription of Clozapine. His choreiform movement disorder also improved as his mental state settled. Although some reported cases of clinical lycanthropy are related to neurological conditions, this is the first case in a patient with HD. We also discuss the relevance of cultural and personal factors in the expression of a delusion that incorporates disgust, and the potential role of somatosensory aberrations and misidentification of self.<\/jats:p>","DOI":"10.3389\/fpsyt.2023.1089872","type":"journal-article","created":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T05:11:48Z","timestamp":1674796308000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Case report: Clinical lycanthropy in Huntington's disease"],"prefix":"10.3389","volume":"14","author":[{"given":"Nick","family":"Medford","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha","family":"Sigala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,1,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1111\/ene.13413","article-title":"Huntington's disease: a clinical review","volume":"25","author":"McColgan","year":"2018","journal-title":"Eur J Neurol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1016\/j.ajhg.2019.04.007","article-title":"Length of uninterrupted CAG, Independent of polyglutamine size, results in increased somatic instability, hastening onset of huntington disease","volume":"104","author":"Wright","year":"2019","journal-title":"Am J Hum Genet."},{"key":"B3","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1016\/j.neubiorev.2013.01.022","article-title":"Structural MRI in Huntington's disease and recommendations for its potential use in clinical trials","volume":"37","author":"Georgiou-Karistianis","year":"2013","journal-title":"Neurosci Biobehav Rev."},{"key":"B4","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1176\/jnp.2007.19.4.441","article-title":"Psychopathology in verified Huntington's disease gene carriers","volume":"19","author":"Van Duijn","year":"2007","journal-title":"J Neuropsychiat Clin Neurosci."},{"key":"B5","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.ajp.2020.102345","article-title":"Management of neuropsychiatric symptoms in Huntington's disease (HD) with clozapine: a case report","author":"Sharma","year":"2020","journal-title":"Asian J Psychiatr."},{"key":"B6","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1002\/pnp.664","article-title":"Treatment of psychosis in Huntington's disease with clozapine","volume":"24","author":"Majothi","year":"2020","journal-title":"Prog Neurol Psychiatry."},{"key":"B7","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1177\/00048674211013082","article-title":"Clozapine treatment for Huntington's disease psychosis","volume":"56","author":"Bampton","year":"2022","journal-title":"Aust N Z J Psychiatry."},{"key":"B8","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1212\/WNL.44.5.821","article-title":"Clozapine in Huntington's chorea","volume":"44","author":"Bonuccelli","year":"1994","journal-title":"Neurology."},{"key":"B9","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1136\/jnnp.63.1.35","article-title":"Clozapine versus placebo in Huntington's disease: a double blind randomised comparative study","volume":"63","author":"Van Vugt","year":"1997","journal-title":"J Neurol Neurosurg Psychiatry."},{"key":"B10","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1136\/jnnp.2009.181149","article-title":"Factor analysis of behavioural symptoms in Huntington's disease","volume":"82","author":"Rickards","year":"2011","journal-title":"J Neurol Neurosurg Psychiatry."},{"key":"B11","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1017\/S003329170000194X","article-title":"Lycanthropy: alive and well in the twentieth century","volume":"18","author":"Keck","year":"1988","journal-title":"Psychol Med."},{"key":"B12","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1177\/014107688908200115","article-title":"Lycanthropy \u2014a review","volume":"82","author":"Fahy","year":"1989","journal-title":"J R Soc Med."},{"key":"B13","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/BF01146453","article-title":"Medical and neuropsychiatric aspects of lycanthropy","volume":"13","author":"Drake","year":"1992","journal-title":"J Med Humanit."},{"key":"B14","unstructured":"Lycaon. 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