{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T16:05:16Z","timestamp":1783008316830,"version":"3.54.5"},"reference-count":49,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T00:00:00Z","timestamp":1704844800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:p>Autism Spectrum Disorder (ASD) is defined as a neurodevelopmental disorder largely investigated in the neurologic field. Recently, neuroimaging studies have been conducted in order to investigate cerebral morphologic alterations in ASD patients, demonstrating an atypical brain development before the clinical manifestations of the disorder. Cortical Thickness (CT) and Local Gyrification Index (LGI) distribution for ASD children were investigated in this study, with the aim to evaluate possible relationship between brain measures and individual characteristics (i.e., IQ and verbal ability). 3D T1-w sequences from 129 ASD and 58 age-matched Healthy Controls (HC) were acquired and processed in order to assess CT and LGI for each subject. Intergroup differences between ASD and HC were investigated, including analyses of 2 ASD subgroups, split according to patient verbal ability and IQ. When compared to HC, ASD showed increased CT and LGI within several brain areas, both as an overall group and as verbal ability an IQ subgroups. Moreover, when comparing language characteristics of the ASD subjects, those patients with verbal ability exhibit significant CT and LGI increase was found within the occipital lobe of right hemisphere. No significant results occurred when comparing ASD patients according to their IQ value. These results support the hypothesis of abnormal brain maturation in ASD since early childhood with differences among clinical subgroups suggesting different anatomical substrates underlying an aberrant connectivity.<\/jats:p>","DOI":"10.3389\/fpsyt.2023.1098265","type":"journal-article","created":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T04:26:08Z","timestamp":1704860768000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Assessing cortical features in early stage ASD children"],"prefix":"10.3389","volume":"14","author":[{"given":"Antonio","family":"Napolitano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Guerrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Lucignani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Parrillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Baldassari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Bottino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Moltoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Camilla Rossi","family":"Espagnet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo Fig\u00e0","family":"Talamanca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Valeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Vicari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,1,10]]},"reference":[{"key":"ref1","volume-title":"Diagnostic and statistical manual of mental disorders","year":"2013"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.15585\/mmwr.ss6706a1","article-title":"Prevalence of autism Spectrum disorder among children aged 8 years \u2014 autism and developmental disabilities monitoring network, 11 sites, United States, 2014","volume":"67","author":"Jon Baio","year":"2018","journal-title":"MMWR Surveill Summ"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1038\/mp.2017.131","article-title":"Toward a conceptual framework for early brain and behavior development in autism","volume":"22","author":"Piven","year":"2017","journal-title":"Mol Psychiatry"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"eaag2882","DOI":"10.1126\/scitranslmed.aag2882","article-title":"Functional neuroimaging of high-risk 6-month-old infants predicts a diagnosis of autism at 24 months of age","volume":"9","author":"Emerson","year":"2017","journal-title":"Sci Transl Med"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1176\/appi.ajp.2012.11091425","article-title":"Brain volume findings in 6-month-old infants at high familial risk for autism","volume":"169","author":"Hazlett","year":"2012","journal-title":"Am J Psychiatry"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1001\/archgenpsychiatry.2011.39","article-title":"Early brain overgrowth in autism associated with an increase in cortical surface area before age 2 years","volume":"68","author":"Hazlett","year":"2011","journal-title":"Arch Gen Psychiatry"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1038\/nature21369","article-title":"Early brain development in infants at high risk for autism spectrum disorder","volume":"542","author":"Hazlett","year":"2017","journal-title":"Nature"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1212\/WNL.57.2.245","article-title":"Unusual brain growth patterns in early life in patients with autistic disorder: an MRI study","volume":"57","author":"Courchesne","year":"2001","journal-title":"Neurology"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1001\/jama.290.3.337","article-title":"Evidence of brain overgrowth in the first year of life in autism","volume":"290","author":"Courchesne","year":"2003","journal-title":"JAMA"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.biopsych.2005.03.026","article-title":"When is the brain enlarged in autism? 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