{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T11:30:59Z","timestamp":1791718259240,"version":"4.3.4"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T00:00:00Z","timestamp":1681430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Previous research has linked polymorphisms in the <jats:italic>SIRT1<\/jats:italic> gene to depressive symptoms, particularly in Chinese individuals. However, it is not clear how personality traits may contribute to this association.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To explore the potential mediating effect of personality traits, we utilized a mediation model to examine the relationship between the <jats:italic>SIRT1<\/jats:italic> rs12415800 polymorphism and depressive symptoms in 787 Chinese college students. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression (CES-D) scale, while personality traits were measured using the Big Five Inventory (BFI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our analysis indicated a significant association between the <jats:italic>SIRT1<\/jats:italic> rs12415800 polymorphism and depressive symptoms, with this relationship partially mediated by the personality traits of neuroticism and conscientiousness. Specifically, individuals who were heterozygous for the rs12415800 polymorphism and had higher levels of conscientiousness were less likely to experience depressive symptoms. Conversely, those who were homozygous for the rs12415800 polymorphism and had higher levels of neuroticism were more likely to experience depressive symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggest that personality traits, particularly neuroticism and conscientiousness, may play a critical role in the association between the <jats:italic>SIRT1<\/jats:italic> rs12415800 polymorphism and depressive symptoms among Chinese college students. These findings highlight the importance of considering both genetic factors and personality traits when exploring the etiology of depressive symptoms in this population.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpsyt.2023.1104664","type":"journal-article","created":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T05:40:46Z","timestamp":1681450846000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Personality traits as mediators in the association between SIRT1 rs12415800 polymorphism and depressive symptoms among Chinese college students"],"prefix":"10.3389","volume":"14","author":[{"given":"Chenliu","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Decheng","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangjie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenming","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengping","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifeng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunying","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenghui","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanxin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,4,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.psc.2009.06.002","article-title":"Anxiety and anxiety disorders in children and adolescents: developmental issues and implications for DSM-V","volume":"32","author":"Beesdo","year":"2009","journal-title":"Psychiatr Clin North Am"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1016\/j.jad.2019.11.058","article-title":"Psychological interventions for depression in Chinese university students: a systematic review and meta-analysis","volume":"262","author":"Fu","year":"2020","journal-title":"J Affect Disord"},{"key":"ref3","first-page":"655201","article-title":"Prevalence and associated factors of depression among college students in China during the COVID-19 pandemic","volume":"12","author":"Cheng","year":"2021","journal-title":"Front Psych"},{"key":"ref4","first-page":"353","article-title":"Consequences of neglecting the elevated rates of depression among college students","volume":"75","author":"Hunt","year":"2018","journal-title":"JAMA Psychiat"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.jpsychires.2012.11.015","article-title":"A systematic review of studies of depression prevalence in university students","volume":"47","author":"Ibrahim","year":"2013","journal-title":"J Psychiatr Res"},{"key":"ref6","first-page":"748","article-title":"Depression, anxiety and academic stress among college students: A brief review","volume":"8","author":"Bhujade","year":"2017","journal-title":"Indian J. 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