{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T16:41:36Z","timestamp":1757781696403,"version":"3.41.2"},"reference-count":56,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T00:00:00Z","timestamp":1678320000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:sec><jats:title>Backgrounds<\/jats:title><jats:p>Decision-making deficits have been reported as trans-diagnostic characteristics of vulnerability to suicidal behaviors, independent of co-existing psychiatric disorders. Individuals with suicidal behaviors often regret their decision to attempt suicide and may have impairments in future-oriented processing. However, it is not clear how people with suicidal dispositions use future-oriented cognition and past experience of regret to guide decision-making. Here, we examined the processes of regret anticipation and experience in subclinical youth with and without suicidal ideation during value-based decision-making.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In total, 80 young adults with suicidal ideation and 79 healthy controls completed a computational counterfactual thinking task and self-reported measures of suicidal behaviors, depression, anxiety, impulsivity, rumination, hopelessness, and childhood maltreatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Individuals with suicidal ideation showed a reduced ability to anticipate regret compared to healthy controls. Specifically, suicidal ideators\u2019 experience of regret\/relief was significantly different from that of healthy controls upon obtained outcomes, while their disappointment\/pleasure experience was not significantly different from healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings suggest that young adults with suicidal ideation have difficulty predicting the consequences or the future value of their behavior. Individuals with suicidal ideation showed impairments in value comparison and flat affect to retrospective rewards, whereas individuals with high suicidality showed blunted affect to immediate rewards. Identifying the counterfactual decision-making characteristics of at-risk suicidal individuals may help to elucidate measurable markers of suicidal vulnerability and identify future intervention targets.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpsyt.2023.1121194","type":"journal-article","created":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T06:48:33Z","timestamp":1678344513000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Dissociated deficits of anticipated and experienced regret in at-risk suicidal individuals"],"prefix":"10.3389","volume":"14","author":[{"given":"Hui","family":"Ai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lian","family":"Duan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuejia","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9","family":"Aleman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengfei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,3,9]]},"reference":[{"key":"ref1","unstructured":"GenevaWorld Health OrganizationSuicide in the world: Global Health estimates2019"},{"key":"ref2","unstructured":"GenevaWorld Health OrganizationDepression and other common mental disorders: global health estimates2017"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1037\/bul0000084","article-title":"Risk factors for suicidal thoughts and behaviors: a meta-analysis of 50 years of research","volume":"143","author":"Franklin","year":"2017","journal-title":"Psychol Bull"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"e1000123","DOI":"10.1371\/journal.pmed.1000123","article-title":"Cross-national analysis of the associations among mental disorders and suicidal behavior: findings from the WHO world mental health surveys","volume":"6","author":"Nock","year":"2009","journal-title":"PLoS Med"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1038\/s41572-019-0121-0","article-title":"Suicide and suicide risk","volume":"5","author":"Turecki","year":"2019","journal-title":"Nat Rev Dis Primers"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1038\/509421a","article-title":"Mental health: a road map for suicide research and prevention","volume":"509","author":"Aleman","year":"2014","journal-title":"Nature"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.jad.2015.10.001","article-title":"Decision-making in unipolar or bipolar suicide attempters","volume":"190","author":"Richard-Devantoy","year":"2016","journal-title":"J Affect Disord"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"e7","DOI":"10.1038\/tp.2011.6","article-title":"The neuroscience of suicidal behaviors: what can we expect from endophenotype strategies?","volume":"1","author":"Courtet","year":"2011","journal-title":"Transl Psychiatry"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1037\/a0021646","article-title":"Impairment in risk-sensitive decision-making in older suicide attempters with depression","volume":"26","author":"Clark","year":"2011","journal-title":"Psychol Aging"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1176\/appi.ajp.162.2.304","article-title":"Impaired decision making in suicide attempters","volume":"162","author":"Jollant","year":"2005","journal-title":"Am J Psychiatry"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.jad.2006.07.022","article-title":"Impaired decision-making in suicide attempters may increase the risk of problems in affective relationships","volume":"99","author":"Jollant","year":"2007","journal-title":"J Affect Disord"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1016\/j.neuroimage.2010.03.027","article-title":"Decreased activation of lateral orbitofrontal cortex during risky choices under uncertainty is associated with disadvantageous decision-making and suicidal behavior","volume":"51","author":"Jollant","year":"2010","journal-title":"NeuroImage"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.jad.2008.03.019","article-title":"Suicide behavior and neuropsychological assessment of type I bipolar patients","volume":"112","author":"Malloy-Diniz","year":"2009","journal-title":"J Affect Disord"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1017\/S0033291710001832","article-title":"Decision making in euthymic bipolar I and bipolar II disorders","volume":"41","author":"Martino","year":"2011","journal-title":"Psychol Med"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"44","DOI":"10.3389\/fpsyt.2019.00044","article-title":"Neuroimaging correlates of suicidality in decision-making circuits in posttraumatic stress disorder","volume":"10","author":"Barredo","year":"2019","journal-title":"Front Psych"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1177\/070674371405900105","article-title":"Neurocognitive vulnerability: suicidal and homicidal behaviours in patients with schizophrenia","volume":"59","author":"Richard-Devantoy","year":"2014","journal-title":"Can J Psychiatr"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.psychres.2013.01.030","article-title":"Iowa gambling task performance in currently depressed suicide attempters","volume":"207","author":"Gorlyn","year":"2013","journal-title":"Psychiatry Res"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1097\/YCO.0000000000000297","article-title":"The decision neuroscience perspective on suicidal behavior: evidence and hypotheses","volume":"30","author":"Dombrovski","year":"2017","journal-title":"Curr Opin Psychiatry"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1521\/jscp.2013.32.4.446","article-title":"Escaping the future: affective forecasting in escapist fantasy and attempted suicide","volume":"32","author":"Marroquin","year":"2013","journal-title":"J Soc Clin Psychol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1037\/a0014716","article-title":"Anticipating one's troubles: the costs and benefits of negative expectations","volume":"9","author":"Golub","year":"2009","journal-title":"Emotion"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"2180","DOI":"10.1176\/appi.ajp.162.11.2180","article-title":"Suicide attempters' reaction to survival as a risk factor for eventual suicide","volume":"162","author":"Henriques","year":"2005","journal-title":"Am J Psychiatry"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/bs.aesp.2017.02.001","article-title":"The functional theory of counterfactual 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In J. M. Olson (Ed.)","volume":"56","author":"Roese","year":"2017","journal-title":"Adv Exp Soc Psychol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1080\/026999300402781","article-title":"On bad decisions and disconfirmed expectancies: the psychology of regret and disappointment","volume":"14","author":"Zeelenberg","year":"2010","journal-title":"Cognit Emot"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"319","DOI":"10.3109\/15622975.2011.556200","article-title":"The suicidal mind and brain: a review of neuropsychological and neuroimaging studies","volume":"12","author":"Jollant","year":"2011","journal-title":"World J Biol Psychiatry"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1126\/science.1094550","article-title":"The involvement of the orbitofrontal cortex in the experience of regret","volume":"304","author":"Camille","year":"2004","journal-title":"Science"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"460","DOI":"10.3758\/CABN.10.4.460","article-title":"Striatal sensitivity to personal responsibility in a regret-based decision-making task","volume":"10","author":"Camille","year":"2010","journal-title":"Cogn Affect Behav Neurosci"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.jpsychires.2018.08.018","article-title":"Differential relations of suicidality in depression to brain activation during emotional and executive processing","volume":"105","author":"Ai","year":"2018","journal-title":"J Psychiatr Res"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1006\/obhd.1999.2865","article-title":"Regret and responsibility resolved? Evaluating Ordonez and Connolly's (2000) conclusions","volume":"81","author":"Zeelenberg","year":"2000","journal-title":"Organ Behav Hum Decis Process"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1176\/appi.ajp.2009.09030407","article-title":"Reward\/punishment reversal learning in older suicide attempters","volume":"167","author":"Dombrovski","year":"2010","journal-title":"Am J Psychiatr"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1037\/0022-006X.47.2.343","article-title":"Assessment of suicidal intention: the scale for suicide ideation","volume":"47","author":"Beck","year":"1979","journal-title":"J Consult Clin Psychol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1207\/s15327752jpa6703_13","article-title":"Comparison of Beck depression inventories -IA and -II in psychiatric outpatients","volume":"67","author":"Beck","year":"1996","journal-title":"J Pers Assess"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1002\/1097-4679(199305)49:3<349::aid-jclp2270490308>3.0.co;2-j","article-title":"The Chinese version of the state-trait anxiety inventory: its relationship to different measures of psychological well-being","volume":"49","author":"Shek","year":"1993","journal-title":"J Clin Psychol"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/s0145-2134(02)00541-0","article-title":"Development and validation of a brief screening version of the childhood trauma questionnaire","volume":"27","author":"Bernstein","year":"2003","journal-title":"Child Abuse Negl"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1023\/A:1023910315561","article-title":"Rumination reconsidered: a psychometric analysis","volume":"27","author":"Treynor","year":"2003","journal-title":"Cogn Ther 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processing of economic action-outcome alternatives in obsessive-compulsive disorder: further evidence of impaired goal-directed behavior","volume":"75","author":"Gillan","year":"2014","journal-title":"Biol Psychiatry"},{"volume-title":"Akaike information criterion statistics","year":"1986","author":"Sakamoto","key":"ref39"},{"key":"ref40","first-page":"225","article-title":"Suicide, lethality, and the psychological autopsy","volume":"6","author":"Shneidman","year":"1969","journal-title":"Int Psychiatry Clin"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.biopsych.2020.06.002","article-title":"Neural correlates associated with suicide and non-suicidal self-injury in youth","volume":"89","author":"Auerbach","year":"2021","journal-title":"Biol Psychiatry"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1097\/01.JGP.0000209219.06017.62","article-title":"Future orientation and suicide ideation and attempts in depressed adults ages 50 and over","volume":"14","author":"Hirsch","year":"2006","journal-title":"Am J Geriatr Psychiatry"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1093\/brain\/awn041","article-title":"The human ventromedial frontal lobe is critical for learning from negative feedback","volume":"131","author":"Wheeler","year":"2008","journal-title":"Brain"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1162\/jocn_a_01372","article-title":"Dissociation between private and social counterfactual value signals following ventromedial prefrontal cortex damage","volume":"31","author":"Bault","year":"2019","journal-title":"J Cogn Neurosci"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1038\/s41386-020-0632-0","article-title":"Ventromedial prefrontal value signals and functional connectivity during decision-making in suicidal behavior and impulsivity","volume":"45","author":"Brown","year":"2020","journal-title":"Neuropsychopharmacology"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.jad.2011.03.006","article-title":"Predictors of suicide relative to other deaths in patients with suicide attempts and suicide ideation: a 30-year prospective study","volume":"132","author":"Wenzel","year":"2011","journal-title":"J Affect Disord"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1016\/j.biopsych.2018.10.006","article-title":"Value-based choice, contingency learning, and suicidal behavior in mid- and late-life depression","volume":"85","author":"Dombrovski","year":"2019","journal-title":"Biol Psychiatry"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1016\/j.jad.2013.06.052","article-title":"Distinct alterations in value-based decision-making and cognitive control in suicide attempters: toward a dual neurocognitive model","volume":"151","author":"Richard-Devantoy","year":"2013","journal-title":"J Affect Disord"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"e0193619","DOI":"10.1371\/journal.pone.0193619","article-title":"Relationships between anhedonia, suicidal ideation and suicide attempts in a large sample of physicians","volume":"13","author":"Loas","year":"2018","journal-title":"PLoS One"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.psychres.2014.04.016","article-title":"Anhedonia predicts suicidal ideation in a large psychiatric inpatient sample","volume":"218","author":"Winer","year":"2014","journal-title":"Psychiatry Res"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"e13378","DOI":"10.1111\/psyp.13378","article-title":"Autonomic correlates of lifetime suicidal thoughts and behaviors among adolescents with a history of depression","volume":"56","author":"Yang","year":"2019","journal-title":"Psychophysiology"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.jad.2019.10.056","article-title":"Differential effects of state and trait social anhedonia on suicidal ideation at 3-months follow up","volume":"262","author":"Yang","year":"2020","journal-title":"J Affect Disord"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1176\/ajp.147.2.190","article-title":"Relationship between hopelessness and ultimate suicide: a replication with psychiatric outpatients","volume":"147","author":"Beck","year":"1990","journal-title":"Am J Psychiatr"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1038\/npp.2016.124","article-title":"Dysregulation of striatal dopamine receptor binding in 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