{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T12:48:49Z","timestamp":1787662129116,"version":"build-2736575974"},"reference-count":69,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T00:00:00Z","timestamp":1706054400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Psycho-emotional well-being is essential for living a life of satisfaction and fulfillment. However, depression and anxiety have become the leading mental health issues worldwide, according to the World Health Organization. Both disorders have been linked to stress and other psychological factors. Their genetic basis remains understudied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 2020\u20132021, the psycho-emotional well-being of 30,063 Russians with no known psychiatric history was assessed using the Hospital Anxiety and Depression Scale (HADS) for general mental health and the HADS subscale A (anxiety) for anxiety. Following the original instructions, an anxiety score of \u226511 points was used as the anxiety threshold. A genome-wide association study was performed to find associations between anxiety and HADS\/HADS-A scores using linear and logistic regressions based on HADS\/HADS-A scores as binary and continuous variables, respectively. In addition, the links between anxiety, sociodemographic factors (such as age, sex, and employment), lifestyle (such as physical activity, sleep duration, and smoking), and markers of caffeine and alcohol metabolism were analyzed. To assess the risk of anxiety, polygenic risk score modeling was carried out using open-access software and principal component analysis (PCA) to simplify the calculations (ROC AUC\u2009=\u200989.4\u2009\u00b1\u20092.2% on the test set).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a strong positive association between HADS\/HADS-A scores and sociodemographic factors and lifestyle. New single-nucleotide polymorphisms (SNPs) with genome-wide significance were discovered, which had not been associated with anxiety or other stress-related conditions but were located in genes previously associated with bipolar disorder, schizophrenia, or emotional instability. The <jats:italic>CACNA1C<\/jats:italic> variant <jats:italic>rs1205787230<\/jats:italic> was associated with clinical anxiety (a HADS-A score of \u226511 points). There was an association between anxiety levels (HADS-A scores) and genes involved in the activity of excitatory neurotransmitters: <jats:italic>PTPRN2 (rs3857647)<\/jats:italic>, <jats:italic>DLGAP4 (rs8114927)<\/jats:italic>, and <jats:italic>STK24 (rs9517326)<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggest that calcium channels and monoamine neurotransmitters, as well as SNPs in genes directly or indirectly affecting neurogenesis and synaptic functions, may be involved in the development of increased anxiety. The role of some non-genetic factors and the clinical significance of physiological markers such as lifestyle were also demonstrated.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpsyt.2023.1188427","type":"journal-article","created":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T04:20:07Z","timestamp":1706070007000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Genetics of psycho-emotional well-being: genome-wide association study and polygenic risk score analysis"],"prefix":"10.3389","volume":"14","author":[{"given":"Anna Yurievna","family":"Yakovchik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darya V.","family":"Tolynyova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daria A.","family":"Kashtanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina R.","family":"Sutulova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhail V.","family":"Ivanov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra A.","family":"Mamchur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika V.","family":"Erema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena R.","family":"Matkava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhail V.","family":"Terekhov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonina M.","family":"Rumyantseva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga I.","family":"Blinova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra I.","family":"Akinshina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey I.","family":"Mitrofanov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir S.","family":"Yudin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentin V.","family":"Makarov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton \u0410.","family":"Keskinov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey A.","family":"Kraevoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey M.","family":"Yudin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,1,24]]},"reference":[{"key":"ref1","unstructured":"2017"},{"key":"ref2","unstructured":"2022"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"S28","DOI":"10.5694\/mjao12.10628","article-title":"Depression and anxiety","volume":"199","author":"Tiller","year":"2013","journal-title":"Med J Aust"},{"key":"ref4","unstructured":"2022"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.encep.2011.12.003","article-title":"Posttraumatic stress disorder (PTSD) as a consequence of the interaction between an individual genetic susceptibility, a traumatogenic event and a social context","volume":"38","author":"Aux\u00e9m\u00e9ry","year":"2012","journal-title":"Enc\u00e9phale"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1568","DOI":"10.1176\/appi.ajp.158.10.1568","article-title":"A review and meta-analysis of the genetic epidemiology of anxiety disorders","volume":"158","author":"Hettema","year":"2001","journal-title":"Am J Psychiatry"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1007\/s11920-019-1002-7","article-title":"Genetics of anxiety disorders","volume":"21","author":"Meier","year":"2019","journal-title":"Curr Psychiatry Rep"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1159\/000351932","article-title":"Genetic factors in anxiety disorders","volume":"29","author":"Domschke","year":"2013","journal-title":"Mod trends Pharmacopsychiatry"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"3292","DOI":"10.1038\/s41380-019-0559-1","article-title":"A major role for common genetic variation in anxiety disorders","volume":"25","author":"Purves","year":"2020","journal-title":"Mol Psychiatry"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1176\/appi.ajp.2019.19030256","article-title":"Reproducible genetic risk loci for anxiety: results from \u223c200, 000 participants in the million veteran program","volume":"177","author":"Levey","year":"2020","journal-title":"Am J Psychiatry"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/1471-2296-10-58","article-title":"Detecting depressive and anxiety disorders in distressed patients in primary care; comparative diagnostic accuracy of the four-dimensional symptom questionnaire (4DSQ) and the hospital anxiety and depression scale (HADS)","volume":"10","author":"Terluin","year":"2009","journal-title":"BMC Fam Pract"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.jpsychores.2011.06.008","article-title":"Latent structure of the hospital anxiety and depression scale: a 10-year systematic review","volume":"72","author":"Cosco","year":"2012","journal-title":"J Psychosom Res"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"i3857","DOI":"10.1136\/bmj.i3857","article-title":"Physical activity and risk of breast cancer, colon cancer, diabetes, ischemic heart disease, and ischemic stroke events: systematic review and dose-response meta-analysis for the global burden of disease study 2013","volume":"354","author":"Kyu","year":"2016","journal-title":"BMJ"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"2287","DOI":"10.1016\/S0140-6736(15)00128-2","article-title":"Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990-2013: a systematic analysis for the global burden of disease study 2013","volume":"386","author":"Forouzanfar","year":"2015","journal-title":"Lancet"},{"key":"ref15","unstructured":"2022"},{"key":"ref16","unstructured":"2022"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","article-title":"The sequence alignment\/map format and SAMtools","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1093\/bioinformatics\/btx699","article-title":"Mosdepth: quick coverage calculation for genomes and exomes","volume":"34","author":"Pedersen","year":"2018","journal-title":"Bioinformatics"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1038\/s41592-018-0051-x","article-title":"Strelka 2: fast and accurate calling of germline and somatic variants","volume":"15","author":"Kim","year":"2018","journal-title":"Nat Methods"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"632385","DOI":"10.3389\/fgene.2021.632385","article-title":"An improved genome-wide polygenic score model for predicting the risk of type 2 diabetes","volume":"12","author":"Liu","year":"2021","journal-title":"Front Genet"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1038\/mp.2017.101","article-title":"Genetic contributors to variation in alcohol consumption vary by race\/ethnicity in a large multi-ethnic genome-wide association study","volume":"22","author":"Jorgenson","year":"2017","journal-title":"Mol Psychiatry"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1656","DOI":"10.1038\/s41593-018-0275-1","article-title":"Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders","volume":"21","author":"Walters","year":"2018","journal-title":"Nat Neurosci"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1001\/archpsyc.1994.03950010008002","article-title":"Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey","volume":"51","author":"Kessler","year":"1994","journal-title":"Arch Gen Psychiatry"},{"key":"ref24","first-page":"1485","volume-title":"Mental health and marital status. The Wiley Blackwell encyclopedia of health, illness, behavior, and society","author":"Spiker","year":"2014"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1097\/JGP.0b013e3181c294ac","article-title":"Effect of age on the frequency of anxiety disorders in major depression with psychotic features","volume":"18","author":"Flint","year":"2010","journal-title":"Am J Geriatr Psychiatry"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1007\/s11606-018-4373-2","article-title":"Effects of sleep, physical activity, and shift work on daily mood: a prospective Mobile monitoring study of medical interns","volume":"33","author":"Kalmbach","year":"2018","journal-title":"J Gen Intern Med"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1002\/brb3.137","article-title":"How cigarette smoking may increase the risk of anxiety symptoms and anxiety disorders: a critical review of biological pathways","volume":"3","author":"Moylan","year":"2013","journal-title":"Brain Behav"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1037\/0033-2909.133.2.245","article-title":"Anxiety, anxiety disorders, tobacco use, and nicotine: a critical review of interrelationships","volume":"133","author":"Morissette","year":"2007","journal-title":"Psychol Bull"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1017\/ipm.2017.25","article-title":"Anxiety and depression among patients with alcohol dependence: co-morbid or substance-related problems?","volume":"35","author":"Gallagher","year":"2018","journal-title":"Ir J Psychol Med"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1002\/j.1552-4604.1997.tb04356.x","article-title":"Dose-dependent pharmacokinetics and psychomotor effects of caffeine in humans","volume":"37","author":"Kaplan","year":"1997","journal-title":"J Clin Pharmacol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"957","DOI":"10.15288\/jsad.2015.76.957","article-title":"Decomposing the relationship between anxiety sensitivity and alcohol use","volume":"76","author":"Chavarria","year":"2015","journal-title":"J Stud Alcohol Drugs"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1124\/pr.117.014407","article-title":"Interindividual differences in caffeine metabolism and factors driving caffeine consumption","volume":"70","author":"Nehlig","year":"2018","journal-title":"Pharmacol Rev"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3390\/nu10101352","article-title":"The role of genetics in moderating the inter-individual differences in the Ergogenicity of caffeine","volume":"10","author":"Southward","year":"2018","journal-title":"Nutrients"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"2791","DOI":"10.1038\/npp.2008.17","article-title":"Association between ADORA2A and DRD2 polymorphisms and caffeine-induced anxiety","volume":"33","author":"Childs","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.genhosppsych.2017.04.007","article-title":"Physical activity correlates in people with anxiety: data from 46 low-and middle-income countries","volume":"49","author":"Vancampfort","year":"2017","journal-title":"Gen Hosp Psychiatry"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.pneurobio.2012.06.001","article-title":"CACNA1C (Cav 1.2) in the pathophysiology of psychiatric disease","volume":"99","author":"Bhat","year":"2012","journal-title":"Prog Neurobiol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1038\/ng.209","article-title":"Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder","volume":"40","author":"Ferreira","year":"2008","journal-title":"Nat Genet"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"e56970","DOI":"10.1371\/journal.pone.0056970","article-title":"CACNA1C risk variant and amygdala activity in bipolar disorder, schizophrenia and healthy controls","volume":"8","author":"Tesli","year":"2013","journal-title":"PLoS One"},{"key":"ref39","article-title":"The role of the amygdala in anxiety disorders","volume-title":"The amygdala \u2013 a discrete multitasking manager","author":"Forster","year":"2012"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"1476","DOI":"10.1176\/appi.ajp.2007.07030504","article-title":"Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia","volume":"164","author":"Etkin","year":"2007","journal-title":"Am J Psychiatry"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1073\/pnas.2108768119","article-title":"Disrupted gene expression perturbs spontaneous ca activity causing abnormal brain development and increased anxiety","volume":"119","author":"Smedler","year":"2022","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.bbrc.2019.03.163","article-title":"Piezo1 mediates neuron oxygen-glucose deprivation\/reoxygenation injury via ca\/calpain signaling","volume":"513","author":"Wang","year":"2019","journal-title":"Biochem Biophys Res Commun"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"2201","DOI":"10.3389\/fpsyg.2018.02201","article-title":"Emotional roles of mono-Aminergic neurotransmitters in major depressive disorder and anxiety disorders","volume":"9","author":"Liu","year":"2018","journal-title":"Front Psychol"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"347","DOI":"10.3389\/fnins.2021.738347","article-title":"Identification of DNA methylation changes that predict onset of post-traumatic stress disorder and depression following physical trauma","volume":"15","author":"Martin","year":"2021","journal-title":"Front Neurosci"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1111\/cns.13391","article-title":"STK24 modulates excitatory synaptic transmission in epileptic hippocampal neurons","volume":"26","author":"Yang","year":"2020","journal-title":"CNS Neurosci Ther"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"7501","DOI":"10.1073\/pnas.0813386106","article-title":"Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry","volume":"106","author":"Scott","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.1007\/s00702-008-0119-3","article-title":"Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies","volume":"115","author":"Lesch","year":"2008","journal-title":"J Neural Transm"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1001\/jamapsychiatry.2017.1986","article-title":"Identification of genetic loci jointly influencing schizophrenia risk and the cognitive traits of verbal-numerical reasoning, reaction time, and general cognitive function","volume":"74","author":"Smeland","year":"2017","journal-title":"JAMA Psychiat"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"14","DOI":"10.3390\/ph14090850","article-title":"Catenin alpha 2 may be a biomarker or potential drug target in psychiatric disorders with perseverative negative thinking","volume":"14","author":"Eszlari","year":"2021","journal-title":"Pharmaceuticals"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1038\/ng908","article-title":"Deletion in Catna 2, encoding alpha N-catenin, causes cerebellar and hippocampal lamination defects and impaired startle modulation","volume":"31","author":"Park","year":"2002","journal-title":"Nat Genet"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"6609","DOI":"10.1038\/s41380-021-01156-4","article-title":"Infant inhibited temperament in primates predicts adult behavior, is heritable, and is associated with anxiety-relevant genetic variation","volume":"26","author":"Fox","year":"2021","journal-title":"Mol Psychiatry"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.smrv.2017.08.002","article-title":"Genetics of restless legs syndrome: an update","volume":"39","author":"Jim\u00e9nez-Jim\u00e9nez","year":"2018","journal-title":"Sleep Med Rev"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1038\/npp.2014.290","article-title":"Genome-wide association study of copy number variations (CNVs) with opioid dependence","volume":"40","author":"Li","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1111\/nyas.14002","article-title":"PTPRD: neurobiology, genetics, and initial pharmacology of a pleiotropic contributor to brain phenotypes","volume":"1451","author":"Uhl","year":"2019","journal-title":"Ann N Y Acad Sci"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.1038\/mp.2017.20","article-title":"Susceptibility to neurofibrillary tangles: role of the PTPRD locus and limited pleiotropy with other neuropathologies","volume":"23","author":"Chibnik","year":"2018","journal-title":"Mol Psychiatry"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1186\/s12916-021-02039-9","article-title":"Genome-wide association study followed by trans-ancestry meta-analysis identify 17 new risk loci for schizophrenia","volume":"19","author":"Liu","year":"2021","journal-title":"BMC Med"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1038\/s41586-022-04434-5","article-title":"Mapping genomic loci implicates genes and synaptic biology in schizophrenia","volume":"604","author":"Trubetskoy","year":"2022","journal-title":"Nature"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1038\/mp.2017.154","article-title":"Revealing the complex genetic architecture of obsessive-compulsive disorder using meta-analysis","volume":"23","year":"2018","journal-title":"Mol Psychiatry"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.1038\/s41398-017-0012-7","article-title":"Genome-wide analysis in UK biobank identifies four loci associated with mood instability and genetic correlation with major depressive disorder, anxiety disorder and schizophrenia","volume":"7","author":"Ward","year":"2017","journal-title":"Transl Psychiatry"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/s13041-017-0324-9","article-title":"The DLGAP family: neuronal expression, function and role in brain disorders","volume":"10","author":"Rasmussen","year":"2017","journal-title":"Mol Brain"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1017\/S1092852900010427","article-title":"The role of glutamate in anxiety and related disorders","volume":"10","author":"Cortese","year":"2005","journal-title":"CNS Spectr"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.5772\/19919","article-title":"The loss of glutamate-GABA harmony in anxiety disorders. Anxiety disorders","author":"Wiero\u0144ska","year":"2011","journal-title":"Intech"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"41130","DOI":"10.1038\/srep41130","article-title":"SRRM4-dependent neuron-specific alternative splicing of protrudin transcripts regulates neurite outgrowth","volume":"7","author":"Ohnishi","year":"2017","journal-title":"Sci Rep"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/s12014-021-09320-2","article-title":"The plasma peptides of Alzheimer\u2019s disease","volume":"18","author":"Florentinus-Mefailoski","year":"2021","journal-title":"Clin Proteomics"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"9","DOI":"10.3390\/cells9071734","article-title":"Interplay of TRIM2 E3 ubiquitin ligase and ALIX\/ESCRT complex: control of developmental plasticity during early neurogenesis","volume":"9","author":"Lokapally","year":"2020","journal-title":"Cells"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/1749-8104-4-18","article-title":"Semaphorin 5B mediates synapse elimination in hippocampal neurons","volume":"4","author":"O\u2019Connor","year":"2009","journal-title":"Neural Dev"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1038\/nn.2387","article-title":"SOX6 controls dorsal progenitor identity and interneuron diversity during neocortical development","volume":"12","author":"Azim","year":"2009","journal-title":"Nat Neurosci"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"6967","DOI":"10.1523\/JNEUROSCI.0025-12.2012","article-title":"S-SCAM\/MAGI-2 is an essential synaptic scaffolding molecule for the Glu A2-containing maintenance pool of AMPA receptors","volume":"32","author":"Danielson","year":"2012","journal-title":"J Neurosci"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"1841","DOI":"10.1002\/humu.23803","article-title":"Disease-associated missense variants in ZBTB18 disrupt DNA binding and impair the development of neurons within the embryonic cerebral cortex","volume":"40","author":"Hemming","year":"2019","journal-title":"Hum Mutat"}],"container-title":["Frontiers in Psychiatry"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpsyt.2023.1188427\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T04:20:12Z","timestamp":1706070012000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpsyt.2023.1188427\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,24]]},"references-count":69,"alternative-id":["10.3389\/fpsyt.2023.1188427"],"URL":"https:\/\/doi.org\/10.3389\/fpsyt.2023.1188427","relation":{},"ISSN":["1664-0640"],"issn-type":[{"value":"1664-0640","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,24]]},"article-number":"1188427"}}