{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T10:35:39Z","timestamp":1780050939813,"version":"3.53.1"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T00:00:00Z","timestamp":1691366400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Mental disorders pose a high risk for the occurrence of sexual dysfunctions (SD). This study aimed to investigate prevalence of risk factors and help-seeking behavior for sexual dysfunctions in patients with opioid use disorder compared to patients seeking psychotherapeutic help.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ninety-seven patients at two opioid agonist treatment (OAT) centers and 65 psychotherapeutic patients from a psychiatric practice (PP) in Switzerland were included in the study. Self-report assessments comprised sexual functioning (IIEF: International Index of Erectile Function; FSFI: Female Sexual Function Index), depressive state, psychological distress, alcohol consumption, nicotine use, and a self-designed questionnaire on help-seeking behavior. We used chi-squared and Mann\u2013Whitney U tests for group comparisons and binary logistic regression models to identify variables predicting the occurrence of sexual dysfunctions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no statistically significant difference (<jats:italic>p<\/jats:italic> =\u20090.140) in the prevalence of SD between OAT (<jats:italic>n<\/jats:italic> =\u200964, 66.0%) and PP sample (<jats:italic>n<\/jats:italic> =\u200935, 53.8%). OAT patients scored significantly higher in scales assessing nicotine use (<jats:italic>p<\/jats:italic> &amp;lt;\u20090.001) and depressive state (<jats:italic>p<\/jats:italic> =\u20090.005). Male OAT patients scored significantly worse on the Erectile Function scale (<jats:italic>p<\/jats:italic> =\u20090.005) and female PP patients scored significantly worse on the FSFI Pain domain (<jats:italic>p<\/jats:italic> =\u20090.022). Opioid use disorder, higher age, and being female predicted the occurrence of SD in the total sample. In the OAT sample, only higher age remained predictive for the occurrence of SD. A lack of help-seeking behavior was observed in both groups, with only 31% of OAT patients and 35% of PP patients ever having talked about their sexual health with their treating physician.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SD are common among psychiatric patients receiving OAT and general psychiatric patients seeking psychotherapy. Professionals providing mental healthcare to patients must emphasize prevention and routine assessments of sexual functioning needs.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpsyt.2023.1204236","type":"journal-article","created":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T13:13:01Z","timestamp":1691413981000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Sexual dysfunction prevalence, risk factors, and help-seeking behavior in opioid agonist treatment and general psychiatry: a cross-sectional study"],"prefix":"10.3389","volume":"14","author":[{"given":"Maximilian","family":"Meyer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean N.","family":"Westenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Brunner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"G\u00fcrtler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard A.","family":"Wiesbeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Undine E.","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Vogel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth M.","family":"D\u00fcrsteler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,8,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.1007\/s10508-014-0426-8","article-title":"Individual and partner correlates of sexual satisfaction and relationship happiness in midlife couples: dyadic analysis of the international survey of relationships","volume":"44","author":"Fisher","year":"2015","journal-title":"Arch Sex Behav"},{"key":"ref2","volume-title":"Diagnostic and statistical manual of mental disorders: DSM-5","year":"2013"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1817","DOI":"10.1016\/S0140-6736(13)62366-1","article-title":"Sexual function in Britain: findings from the third National Survey of sexual attitudes and lifestyles (Natsal-3)","volume":"382","author":"Mitchell","year":"2013","journal-title":"Lancet"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s43045-020-00022-3","article-title":"Sexual dysfunctions in a sample of male psychiatric patients compared to medically ill patients","volume":"27","author":"Abdelatti","year":"2020","journal-title":"Middle East Curr Psychiatry"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.jagp.2014.03.006","article-title":"Sexual health and function in later life: a population-based study of 606 older adults with a partner","volume":"23","author":"Wang","year":"2015","journal-title":"Am J Geriatr Psychiatr"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3389\/fnbeh.2019.00097","article-title":"Sexual functioning and opioid maintenance treatment in women. Results from a large multicentre study","volume":"13","author":"Zamboni","year":"2019","journal-title":"Front Behav Neurosci"},{"key":"ref7","first-page":"1015","article-title":"Bupropion in methadone induced erectile dysfunction","volume":"2","author":"Tatari","year":"2014","journal-title":"Ann Psychiatry Ment Health"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1192\/bjp.182.1.50","article-title":"Nithsdale schizophrenia surveys 24: sexual dysfunction. Case-control study","volume":"182","author":"MacDonald","year":"2003","journal-title":"Br J Psychiatry"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1111\/ppc.12160","article-title":"A study on sexual function in obsessive-compulsive disorder (OCD) patients with and without depressive symptoms","volume":"53","author":"Ghassemzadeh","year":"2017","journal-title":"Perspect Psychiatr Care"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1038\/s41443-022-00539-7","article-title":"Prevalence of sexual dysfunction in depressive and persistent depressive disorders: a systematic review and meta-analysis","volume":"35","author":"Gon\u00e7alves","year":"2022","journal-title":"Int J Impot Res"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1038\/ijir.2014.18","article-title":"Clinical factors associated with sexual dysfunction among men in methadone maintenance treatment and buprenorphine maintenance treatment: a meta-analysis study","volume":"26","author":"Yee","year":"2014","journal-title":"Int J Impot Res"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"88289","DOI":"10.1371\/journal.pone.0088289","article-title":"Sexual dysfunction improved in heroin-dependent men after methadone maintenance treatment in Tianjin, China","volume":"9","author":"Zhang","year":"2014","journal-title":"PLoS One"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fpsyt.2022.846834","article-title":"Sexual dysfunctions in patients receiving opioid agonist treatment and heroin-assisted treatment compared to patients in private practice\u2014identifying group differences and predictors","volume":"13","author":"Meyer","year":"2022","journal-title":"Front Psychiatry"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1111\/j.1743-6109.2007.00702.x","article-title":"Erectile dysfunction in men receiving methadone and buprenorphine maintenance treatment","volume":"5","author":"Hallinan","year":"2008","journal-title":"J Sex Med"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.drugalcdep.2005.07.004","article-title":"Complaints of heroin-maintained patients: a survey of symptoms ascribed to diacetylmorphine","volume":"81","author":"D\u00fcrsteler-MacFarland","year":"2006","journal-title":"Drug Alcohol Depend"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"161","DOI":"10.7326\/0003-4819-139-3-200308050-00005","article-title":"Sexual function in men older than 50 years of age: results from the health professionals follow-up study","volume":"139","author":"Bacon","year":"2003","journal-title":"Ann Intern Med"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.2337\/diacare.28.7.1739","article-title":"Clinical, socioeconomic, and lifestyle parameters associated with erectile dysfunction among diabetic 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Meta-analysis","volume":"8","author":"Cao","year":"2013","journal-title":"PLoS One"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"302","DOI":"10.5468\/ogs.2015.58.4.302","article-title":"Dose-response relationship between cigarette smoking and female sexual dysfunction","volume":"58","author":"Choi","year":"2015","journal-title":"Obstet Gynecol Sci"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1111\/j.1742-1241.2005.00382.x","article-title":"Help-seeking behaviour for sexual problems: the global study of sexual attitudes and behaviors","volume":"59","author":"Moreira","year":"2005","journal-title":"Int J Clin Pract"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1111\/jsm.12395","article-title":"General practitioners\u2019 procedures for sexual history taking and treating sexual dysfunction in primary care","volume":"11","author":"Ribeiro","year":"2014","journal-title":"J Sex 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Psychiatry"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1210\/jc.2004-0929","article-title":"Plasma testosterone and sexual function in men receiving buprenorphine maintenance for opioid dependence","volume":"90","author":"Bliesener","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.drugalcdep.2007.09.025","article-title":"Erectile dysfunction in male heroin users, receiving methadone and buprenorphine maintenance treatment","volume":"94","author":"Quaglio","year":"2008","journal-title":"Drug Alcohol Depend"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.jsat.2010.01.008","article-title":"Symptom complaints of patients prescribed either oral methadone or injectable heroin","volume":"38","author":"D\u00fcrsteler-MacFarland","year":"2010","journal-title":"J Subst Abus 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dysfunction","volume":"49","author":"Rosen","year":"1997","journal-title":"Urology"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/S0090-4295(99)00099-0","article-title":"Diagnostic evaluation of the erectile function domain of the international index of erectile function","volume":"54","author":"Cappelleri","year":"1999","journal-title":"Urology"},{"key":"ref37","first-page":"11","article-title":"Allgemeine Depressionsskala","volume":"1993","author":"Hautzinger","year":"1993","journal-title":"G\u00f6ttingen: Hogrefe"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1177\/014662167700100306","article-title":"The CES-D scale: a self-report depression scale for research in the general population","volume":"1","author":"Radloff","year":"1977","journal-title":"Appl Psychol Meas"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1111\/j.1360-0443.1993.tb02093.x","article-title":"Development of the alcohol use disorders identification test (AUDIT): WHO collaborative project on early detection of persons with harmful alcohol consumption-II","volume":"88","author":"Saunders","year":"1993","journal-title":"Addiction"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1111\/j.1530-0277.2007.00403.x","article-title":"AUDIT-C as a brief screen for alcohol misuse in primary care","volume":"31","author":"Bradley","year":"2007","journal-title":"Alcohol Clin Exp Res"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1111\/j.1360-0443.1991.tb01879.x","article-title":"The Fagerstr\u00f6m test for nicotine dependence: a revision of the Fagerstrom tolerance questionnaire","volume":"86","author":"Heatherton","year":"1991","journal-title":"Br J Addict"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1053\/eujp.2001.0231","article-title":"Cross-validation of the SCL-27: a short psychometric screening instrument for chronic pain patients","volume":"5","author":"Hardt","year":"2001","journal-title":"Eur J Pain"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1023\/A:1008931926181","article-title":"The symptom check-list-90-R (SCL-90-R): a German validation study","volume":"9","author":"Schmitz","year":"2000","journal-title":"Qual Life Res"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep06189","article-title":"Methadone induces testosterone suppression in patients with opioid addiction","volume":"4","author":"Bawor","year":"2014","journal-title":"Sci Rep"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1111\/add.14442","article-title":"One size does not fit all\u2014evolution of opioid agonist treatments in a naturalistic setting over 23 years","volume":"114","author":"Nordt","year":"2019","journal-title":"Addiction"}],"container-title":["Frontiers in 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