{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:30:02Z","timestamp":1791228602746,"version":"4.1.0"},"reference-count":50,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T00:00:00Z","timestamp":1699488000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008349","name":"University of Duisburg-Essen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:p>A comorbidity of anorexia nervosa (AN) and myalgic encephalomyelitis (ME\/CSF) is uncommon. A 17\u2009years-old male adolescent with possible onset of ME\/CFS after an Epstein Barr Virus infection (EBV) and later onset of AN during a second period of weight loss was twice treated off-label with metreleptin for 15 and 11\u2009days, respectively. As in previous cases, eating disorder specific cognitions and mood improved. Interestingly, fatigue and post-exertional muscle pain (P-EMP) improved, too. We discuss potential mechanisms. Treatment with metreleptin may prove beneficial in AN and in ME\/CSF associated with substantial weight loss.<\/jats:p>","DOI":"10.3389\/fpsyt.2023.1267495","type":"journal-article","created":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T04:42:18Z","timestamp":1699850538000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Case report: Rapid improvements of anorexia nervosa and probable myalgic encephalomyelitis\/chronic fatigue syndrome upon metreleptin treatment during two dosing episodes"],"prefix":"10.3389","volume":"14","author":[{"given":"Johannes","family":"Hebebrand","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Antel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"von 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