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Psychiatry"],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Deficits in emotion recognition and processing are characteristic for patients with schizophrenia [SCZ].<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We targeted both emotion recognition and affective sharing, one in static and one in dynamic facial stimuli, during functional magnetic resonance imaging [fMRI] in 22 SCZ patients and 22 matched healthy controls [HC]. Current\u00a0symptomatology and cognitive deficits were assessed as potential influencing factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Behaviorally, patients only showed a prolonged response time in age-discrimination trials. For emotion-processing trials, patients showed a difference in neural response, without an observable behavioral correlate. During emotion and age recognition in static stimuli, a reduced activation of the bilateral anterior cingulate cortex [ACC] and the right anterior insula [AI] emerged. In the affective sharing task, patients showed a reduced activation in the left and right caudate nucleus, right AI and inferior frontal gyrus [IFG], right cerebellum, and left thalamus, key areas of empathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>We conclude that patients have deficits in complex visual information processing regardless of emotional content on a behavioral level and that these deficits coincide with aberrant neural activation patterns in emotion processing networks. The right AI as an integrator of these networks plays a key role in these aberrant neural activation patterns and, thus, is a promising candidate area for neurofeedback approaches.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpsyt.2024.1288028","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T05:04:39Z","timestamp":1716527079000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Empathy in schizophrenia: neural alterations during emotion recognition and affective 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