{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T07:32:51Z","timestamp":1787643171133,"version":"build-2736575974"},"reference-count":61,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T00:00:00Z","timestamp":1719532800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:p>This report examines extended intra-nasal insulin treatment [INI] for an Insulin Resistant early Mild Cognitive Impairment [MCI] patient. Patient [EJ] also had medial temporal lobe [MTL] damage, poor short-term memory, significant irritability, and social and linguistic withdrawal at treatment start. Compared to baseline, nine months INI treatment increased grey matter volume, lowered beta-amyloid levels, and improved MCI and FAS scores. Patient also increased pragmatic capacities in social conversation and procedural memory. These findings align with results from prior clinical trials on INI and suggest that treatment can slow neurodegenerative disease progression in early MCI patients.<\/jats:p>","DOI":"10.3389\/fpsyt.2024.1326702","type":"journal-article","created":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T04:46:40Z","timestamp":1719550000000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Enhancing socio-communicative functions in an MCI patient with intra-nasal insulin: a case report"],"prefix":"10.3389","volume":"15","author":[{"given":"Sara","family":"Schatz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace Rose","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,6,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1001\/archneurol.2011.233","article-title":"Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment","volume":"69","author":"Craft","year":"2012","journal-title":"Arch Neurol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2020.105934","article-title":"Memory advancement by intranasal insulin in type 2 diabetes (MemAID) randomized controlled clinical trial: Design, methods and rationale","volume":"89","author":"Galindo-Mendez","year":"2020","journal-title":"Contemp Clin Trials"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.1840","article-title":"Safety, efficacy, and feasibility of intranasal insulin for the treatment of mild cognitive impairment and alzheimer disease dementia: A randomized clinical trial","volume":"77","author":"Craft","year":"2020","journal-title":"JAMA Neurol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1075\/pc.23.2.07sch","article-title":"Pragmatic function impairment and Alzheimer\u2019s dementia","volume":"23","author":"Schatz","year":"2016","journal-title":"Pragmatics Cogn"},{"key":"B5","article-title":"Executive functioning, visuospatial and inter-personal skill preservation in Alzheimer\u2019s and mild cognitive impairment","volume-title":"Further Advances in Pragmatics and Philosophy: Part 2 Theories and Applications. 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