{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T21:57:31Z","timestamp":1792879051921,"version":"4.5.0"},"reference-count":123,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T00:00:00Z","timestamp":1707436800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:p>Coronary heart disease (CHD), a cardiovascular condition that poses a significant threat to human health and life, has imposed a substantial economic burden on the world. However, in contrast to conventional risk factors, depression emerges as a novel and independent risk factor for CHD. This condition impacts the onset and progression of CHD and elevates the risk of adverse cardiovascular prognostic events in those already affected by CHD. As a result, depression has garnered increasing global attention. Despite this growing awareness, the specific mechanisms through which depression contributes to the development of CHD remain unclear. Existing research suggests that depression primarily influences the inflammatory response, Hypothalamic-pituitary-adrenocortical axis (HPA) and Autonomic Nervous System (ANS) dysfunction, platelet activation, endothelial dysfunction, lipid metabolism disorders, and genetics, all of which play pivotal roles in CHD development. Furthermore, the effectiveness and safety of antidepressant treatment in CHD patients with comorbid depression and its potential impact on the prognosis of CHD patients have become subjects of controversy. Further investigation is warranted to address these unresolved questions.<\/jats:p>","DOI":"10.3389\/fpsyt.2024.1328048","type":"journal-article","created":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T23:50:40Z","timestamp":1707436240000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":65,"title":["Depression and coronary heart disease: mechanisms, interventions, and treatments"],"prefix":"10.3389","volume":"15","author":[{"given":"Linjie","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dazhuo","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,2,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000019","article-title":"Depression as a risk factor for poor prognosis among patients with acute coronary syndrome: systematic review and recommendations: a scientific statement from the American Heart Association","volume":"129","author":"Lichtman","year":"2014","journal-title":"Circulation"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.01.041","article-title":"Screening and management of depression in patients with cardiovascular disease","volume":"73","author":"Jha","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2017.4602","article-title":"Epidemiology of adult DSM-5 major depressive disorder and its specifiers in the United States","volume":"75","author":"Hasin","year":"2018","journal-title":"JAMA Psychiatry"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2016.07.003","article-title":"Depression and cardiovascular disease: Epidemiological evidence on their linking mechanisms","volume":"74","author":"Penninx","year":"2017","journal-title":"Neurosci Biobehav Rev"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-21243-x","article-title":"Prevalence of depression in the community from 30 countries between 1994 and 2014","volume":"8","author":"Lim","year":"2018","journal-title":"Sci Rep"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyx097","article-title":"Worsening anxiety, irritability, insomnia, or panic predicts poorer antidepressant treatment outcomes: clinical utility and validation of the concise associated symptom tracking (CAST) scale","volume":"21","author":"Jha","year":"2018","journal-title":"Int J Neuropsychopharmacol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.2196\/jmir.8372","article-title":"Patterns in patient access and utilization of online medical records: analysis of myChart","volume":"20","author":"Redelmeier","year":"2018","journal-title":"J Med Internet Res"},{"key":"B8","doi-asserted-by":"publisher","first-page":"31","DOI":"10.31887\/DCNS.2018.20.1\/mdehert","article-title":"The intriguing relationship between coronary heart disease and mental disorders","volume":"20","author":"De Hert","year":"2018","journal-title":"Dialogues Clin Neurosci"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0000000000000570","article-title":"Residual symptoms after treatment for depression in patients with coronary heart disease","volume":"80","author":"Carney","year":"2018","journal-title":"Psychosom Med"},{"key":"B10","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1111\/joim.12692","article-title":"Psychosocial stress and major cardiovascular events in patients with stable coronary heart disease","volume":"283","author":"Hagstr\u00f6m","year":"2018","journal-title":"J Intern Med"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1159\/000501502","article-title":"Prevalence, 12-month prognosis, and clinical management need of depression in coronary heart disease patients: A prospective cohort study","volume":"88","author":"Kuhlmann","year":"2019","journal-title":"Psychother Psychosom"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1097\/01.psy.0000174169.14227.1f","article-title":"Does panic disorder increase the risk of coronary heart disease? 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