{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T15:32:39Z","timestamp":1768404759952,"version":"3.49.0"},"reference-count":14,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T00:00:00Z","timestamp":1714089600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:p>Escitalopram is widely prescribed for the treatment of major depressive disorder and generalized anxiety disorder with a well-documented side effects profile. Peripheral edema, however, is a rarely reported adverse reaction that warrants further work up. This paper summarizes the case of a 58-year female patient who developed transient bilateral peripheral edema following the administration of low dose escitalopram. This case underscores the necessity for clinicians to be familiar with even rare potential side effects of commonly prescribed medications. It also suggests a need for patient education regarding the importance of reporting new symptoms promptly.<\/jats:p>","DOI":"10.3389\/fpsyt.2024.1394813","type":"journal-article","created":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T04:47:58Z","timestamp":1714106878000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case report: Escitalopram-associated lower limb edema"],"prefix":"10.3389","volume":"15","author":[{"given":"Mohamed Hassan","family":"Ahmed","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mena","family":"Al-Kubaisi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Safa Abdulmajeed","family":"Al-Rawi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar Hosam","family":"Salama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hebah Mahmoud","family":"Abutayyem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,4,26]]},"reference":[{"key":"B1","article-title":"Escitalopram","volume-title":"StatPearls","author":"Landy","year":"2024"},{"key":"B2","article-title":"Peripheral Edema","volume-title":"StatPearls","author":"Goyal","year":"2024"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-6465(22)00253-5","article-title":"Psychopharmacology and clinical practice","volume":"26","author":"Glod","year":"1991","journal-title":"Nurs Clinics North America"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.14752","article-title":"Drug-induced peripheral oedema: An aetiology-based review","volume":"87","author":"Largeau","year":"2021","journal-title":"Br J Clin Pharmacol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-024-02738-6","article-title":"Edema related to treatment with psychotropic drugs","volume":"131","author":"Engel","year":"2024","journal-title":"J Neural Transm"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2019.7087","article-title":"Evaluation of a common prescribing cascade of calcium channel blockers and diuretics in older adults with hypertension","volume":"180","author":"Savage","year":"2020","journal-title":"JAMA Intern Med"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.9740\/mhc.2020.07.250","article-title":"Gabapentin-induced bilateral lower extremity edema in a patient with pervasive developmental disorder and schizoaffective disorder","volume":"10","author":"Finegan","year":"2020","journal-title":"Ment Health Clinician"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0260742","article-title":"Peripheral edema: A common and persistent health problem for older Americans","volume":"16","author":"Besharat","year":"2021","journal-title":"PloS One"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1002\/hup.2884","article-title":"Peripheral edema associated with antidepressant use: Systematic review of case reports","volume":"38","author":"Joseph","year":"2023","journal-title":"Hum Psychopharmacol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b13-00317","article-title":"5-hydroxytryptamine receptors as targets for drug 204 therapies of vascular-related diseases","volume":"36","author":"Gamoh","year":"2013","journal-title":"Biol Pharm Bull"},{"key":"B11","unstructured":"A rare side effect of escitalopram: Bilateral peripheral edema\n            TumanTC\n            TumanB\n          2018"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-9338(12)75258-6","article-title":"P 213 1091 - Administration of escitalopram and bilateral ankle oedema: case report","author":"Kontoangelos","year":"2012","journal-title":"Eur Psychiatry"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3122\/jabfm.19.2.148","article-title":"Approach to leg edema of 216 unclear etiology","volume":"19","author":"Ely","year":"2006","journal-title":"J Am Board Family Medicine: JABFM"},{"key":"B14","unstructured":"Escitalopram induced peripheral edema\n            BaykanH\n            Yarg\u0131\u00e7L\u0130\n          2021"}],"container-title":["Frontiers in Psychiatry"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpsyt.2024.1394813\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T04:48:01Z","timestamp":1714106881000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpsyt.2024.1394813\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,26]]},"references-count":14,"alternative-id":["10.3389\/fpsyt.2024.1394813"],"URL":"https:\/\/doi.org\/10.3389\/fpsyt.2024.1394813","relation":{},"ISSN":["1664-0640"],"issn-type":[{"value":"1664-0640","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,26]]},"article-number":"1394813"}}