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This study aimed to identify patients meeting criteria for a current major depressive episode (cMDE) among those self-reporting clinically significant depressive symptoms (CSDS) in U.S. SCs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This retrospective sub-analysis of an ongoing multicenter trial included 147 adults (22\u201375 years) referred for sleep disorder evaluation. Participants underwent psychiatric assessments using the Mini-International Neuropsychiatric Interview and Patient Health Questionnaire-9 (PHQ-9), with CSDS defined as PHQ-9 \u226510. Descriptive statistics were compared between patients with\/without a confirmed cMDE using non-parametric tests. Additional Mann-Whitney U tests assessed sleep characteristics by cMDE, major depressive disorder (MDD), and bipolar disorder (BD) (statistical significance, p &amp;lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 147 patients, 57 (38.8%) had a PHQ-9 score \u226510. Among them, 23 (40.3%) were diagnosed with cMDE: 17 (29.8%) met cMDD criteria, and 6 (10.5%) had BD, type I. A significantly lower cMDE prevalence was observed in patients without CSDS. Sleep characteristics showed no significant differences except for a lower N3 percentage in cMDE. BD, type I was associated with higher obstructive sleep apnea comorbidity compared to cMDD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Our findings suggest major depression prevalence in SCs is five times higher than in the general population, highlighting the need for routine depression screening and psychiatric confirmation. This also aids in identifying comorbidities and fostering tailored interventions to improve outcomes.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpsyt.2025.1449360","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T05:22:09Z","timestamp":1745558529000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Uncovering hidden depression: the critical role of depression screening in sleep disorders at U.S. sleep 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