{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T16:07:23Z","timestamp":1789142843285,"version":"build-2803163510"},"reference-count":145,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>It is increasingly recognized that the brain continuously interacts with other body systems such as the immune system, the gut-brain axis, and the endocrine system. Dysfunctions in these systems can impact mental health by altering neurotransmitter levels and the neurochemical environment. This shift in understanding underscores the need for therapeutic strategies that address systemic health and mitochondrial function, alongside psychosocial aspects of the disease, offering a more personalized and adaptive approach to treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>This study utilizes a translational research approach structured through the Work Breakdown Structure methodology, dividing the process into six interconnected Work Packages (WPs). These include systematic literature reviews on endocrine dysfunctions and hormonal therapies in mental disorders, application of Design Thinking for neuroendocrine innovation, and hypothesis exploration of hCG as a systemic adjunctive treatment for psychiatric disorders, culminating in result dissemination and evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Work The study identified multiple mechanistic impacts of human chorionic gonadotropin (hCG) relevant to psychiatric treatment. Key findings from hCG Hormetic Therapy (HHT) include stimulation of sex hormone production, reduction of insulin resistance and systemic inflammation, enhancement of hypothalamic activity to regulate appetite, sleep, and emotions, and LH-like effects on cognition. HHT also increases IGF-1 availability, promoting neuroprotection, cognitive improvements, and reduced mitochondrial dysfunction, restoring cellular function critical for brain health.<\/jats:p><\/jats:sec><jats:sec><jats:title>Implications for Clinical Practice<\/jats:title><jats:p>The findings underscore the significance of enhancing endocrine and metabolic functions as a viable strategy for improving psychiatric care, aligning with trends that advocate holistic treatment strategies. The suggested dose for future research protocols is 500 IU IM per week for at least 10 weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Supporting diverse and varied research is crucial for advancing medical knowledge. Continuous exploration of neuroendocrine dysfunctions in mental disorders using advanced tools from neuroscience, endocrinology, and psychiatry can provide new pathways for more effective and personalized treatments. The study of HHT effects offers insights into complex neuroendocrine interactions, underscoring the potential for innovative therapeutic strategies in psychiatry.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpsyt.2025.1537442","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T10:37:28Z","timestamp":1745923048000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Translational interdisciplinary research on human chorionic gonadotropin\u2019s enhancement of neuroendocrine crosstalk: a novel medical hypothesis for systemic adjunctive treatment of psychiatric disorders"],"prefix":"10.3389","volume":"16","author":[{"given":"Jo\u00e3o Francisco Pollo","family":"Gaspary","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Felipe Dias","family":"Lopes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Geraldo","family":"Camara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,4,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2022.11.003","article-title":"Inflammation-related functional and structural dysconnectivity as a pathway to psychopathology","volume":"93","author":"Goldsmith","year":"2023","journal-title":"Biol Psychiatry"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-015-1492-3","article-title":"Sleep and inflammatory markers in different psychiatric disorders","volume":"124","author":"Krysta","year":"2017","journal-title":"J Neural Transm (Vienna)"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291718004142","article-title":"Inflammatory markers are altered in severe mental disorders independent of comorbid cardiometabolic disease risk factors","volume":"49","author":"M\u00f8rch","year":"2019","journal-title":"psychol Med"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1177\/0706743716646361","article-title":"Mitochondrial dysfunction in psychiatric illness","volume":"61","author":"Anglin","year":"2016","journal-title":"Can J Psychiatry"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2022.08.027","article-title":"Mitochondrial dysfunction in psychiatric disorders","author":"Ni","year":"2022","journal-title":"Schizophr Res"},{"key":"B6","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.mito.2021.10.008","article-title":"Blood biomarkers for assessment of mitochondrial dysfunction: An expert review","volume":"62","author":"Hubens","year":"2022","journal-title":"Mitochondrion"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2017.11.018","article-title":"Mitochondrial etiology of neuropsychiatric disorders","volume":"83","author":"Pei","year":"2018","journal-title":"Biol Psychiatry"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-015-0639-0","article-title":"Hypocretins, neural systems, physiology, and psychiatric disorders","volume":"18","author":"Li","year":"2016","journal-title":"Curr Psychiatry Rep"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.2174\/0113816128251883231031054700","article-title":"Inflammation and mental health disorders: Immunomodulation as a potential therapy for psychiatric conditions","volume":"29","author":"Safari","year":"2023","journal-title":"Curr Pharm Design"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpsm.2017.07.006","article-title":"Psychoneuroimmunology of mental disorders","volume":"11","author":"Soria","year":"2018","journal-title":"Rev Psiquiatr\u00eda y Salud Ment"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1111\/jep.13386","article-title":"Mental health is the health of the whole body: How psychoneuroimmunology & health psychology can inform & improve treatment","volume":"26","author":"Alessi","year":"2020","journal-title":"J Eval Clin Pract"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1177\/0706743716659417","article-title":"Canadian network for mood and anxiety treatments (CANMAT) 2016 clinical guidelines for the management of adults with major depressive disorder: section 3. 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