{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:28:18Z","timestamp":1787027298263,"version":"build-2736575974"},"reference-count":78,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T00:00:00Z","timestamp":1749427200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Among people with post-traumatic stress disorder (PTSD), there is an increased prevalence of age-related diseases. However, the biological mechanisms underlying this phenomenon remain incompletely understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The expression of cystathionine \u03b2-synthase (CBS), one of the main enzymes for endogenous hydrogen sulfide (H\n                      <jats:sub>2<\/jats:sub>\n                      S) production in the brain, is age-dependent. In this study, we examined the influence of CBS\/H\n                      <jats:sub>2<\/jats:sub>\n                      S on anxiety and depression-like behavior following the inescapable foot shock (IFS) procedure during early adolescence (postnatal days 28-35) or adulthood (postnatal days 63-70).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Our results showed that adult PTSD mice exhibited more pronounced decreases in H\n                      <jats:sub>2<\/jats:sub>\n                      S content and CBS expression in the hippocampus, which were associated with anxiety and depression-like behavior compared with adolescent PTSD mice. Administration of exogenous H\n                      <jats:sub>2<\/jats:sub>\n                      S significantly improved anxiety and depression-like behavior, mitigated synaptic plasticity deficits, and activated the CREB\/BDNF signaling pathway in the hippocampus of adolescent PTSD mice. In addition, we found that high dose H\n                      <jats:sub>2<\/jats:sub>\n                      S could improve anxiety and depression-like behavior, mitigate synaptic plasticity deficits, and activate the CREB\/BDNF signaling pathway, as well as increase H\n                      <jats:sub>2<\/jats:sub>\n                      S levels in the hippocampus. In contrast, injection of CBS antibody in the hippocampus of adult mice increased anxiety and depressive-like behavior.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      These results suggest that CBS\/ H\n                      <jats:sub>2<\/jats:sub>\n                      S modulates PTSD-like behaviors in an age-dependent manner and may promote synaptic plasticity through activation of the CREB\/BDNF pathway in the hippocampus of mice after IFS exposure.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpsyt.2025.1546737","type":"journal-article","created":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T01:23:53Z","timestamp":1749432233000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Age-dependent effects of H2S on post-traumatic stress disorder in adolescent and adult mice"],"prefix":"10.3389","volume":"16","author":[{"given":"Bing","family":"Gu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifen","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuwen","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dexiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrus S. 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