{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T15:58:13Z","timestamp":1782316693005,"version":"3.54.5"},"reference-count":131,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:p>The detection of Generalized Anxiety Disorder (GAD) in indigenous populations poses a challenge due to their holistic approach to health, which significantly contrasts with the Western biomedical model. Moreover, conventional assessment tools often overlook cultural particularities, compromising their effectiveness in these contexts.<\/jats:p><jats:sec><jats:title>Objective<\/jats:title><jats:p>Therefore, this study aimed to analyze the diagnostic accuracy of the GAD-7 in the Quechua indigenous population of the Peruvian Andes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>To address this issue, we conducted a case-control study to evaluate the clinical accuracy of the Generalized Anxiety Disorder Test (GAD-7) in rural Quechua communities of the Peruvian Andes. We included 147 GAD patients and 322 controls. The study involved four stages: cultural adaptation of the GAD-7, door-to-door evaluation, blind psychiatric and neuropsychological assessments, and application of the Quechua GAD-7. The adaptation used the Delphi method, focus groups, and bilingual judges. Factor analyses, reliability assessments, and diagnostic utility evaluations were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The Quechua GAD-7 showed high content validity (Aiken\u2019s V &amp;gt; 0.85), strong internal consistency (\u03b1 = 0.912, \u03c9 = 0.85), and an area under the curve of 0.93. With a cutoff score of 11, it achieved 91.3% sensitivity and 86.1% specificity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This is the first study to validate a Western test for GAD in indigenous populations.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpsyt.2025.1565895","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T10:39:29Z","timestamp":1748601569000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical utility of the GAD-7 for detecting generalized anxiety in Quechua indigenous 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