{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T15:05:23Z","timestamp":1774883123446,"version":"3.50.1"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic kidney disease (CKD) is associated with various health complications, including sleep disorders. Understanding the relationship between CKD and sleep disturbances is essential for improving patient management and outcomes in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>This study analyzed data from the National Health and Nutrition Examination Survey (NHANES) across two cycles (2015\u20132016 and 2017-2018), involving 4758 participants aged 20 years and older. Sleep disorders were evaluated via targeted questions from the Sleep Disorders Questionnaire. Chronic kidney disease (CKD) was classified by low estimated glomerular filtration rate (eGFR) and proteinuria. Logistic regression analyses examined the association between sleep disorders and CKD, adjusting for demographic and lifestyle confounders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 4,758 participants, 863 (14%) were diagnosed with chronic kidney disease (CKD). Elevated C-reactive protein (CRP) levels and differential leukocyte counts were observed in the CKD cohort. CKD was associated with increased reports of snoring, sleep apnea, and sleep disturbances, along with higher fatigue levels. A significant positive association between CKD and sleep difficulties persisted in adjusted models. Infrequent snoring (1\u20132 times per week) demonstrated a negative association, whereas excessive daytime sleepiness (16\u201330 times\/month) correlated positively with CKD. Significant associations between sleep disorders and CKD were observed in participants aged &amp;lt;60, with a BMI &amp;lt;28 kg\/m\u00b2, normal blood pressure, and CRP \u22651.8 mg\/L. Sleep disorders were found to be correlated with obesity, hypertension, diabetes, CKD, and proteinuria. Notably, CKD patients with sleep difficulties had markedly elevated CRP levels compared to those without sleep issues, while other inflammatory markers were similarly elevated (P &amp;lt; 0.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients with chronic kidney disease experience higher rates of sleep issues, highlighting the importance of addressing these problems in CKD management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpsyt.2025.1570723","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T06:22:19Z","timestamp":1763446939000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Association between self-reported sleep disorders and prevalence of chronic kidney disease in a nationally representative sample of U.S. adults"],"prefix":"10.3389","volume":"16","author":[{"given":"Hua","family":"Xiao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guobao","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinzhou","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,11,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2016.163","article-title":"The global burden of chronic kidney disease: estimates, variability and pitfalls","volume":"13","author":"Glassock","year":"2017","journal-title":"Nat Rev Nephrology."},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-019-0248-y","article-title":"Targeting the progression of chronic kidney disease","volume":"16","author":"Ruiz-Ortega","year":"2020","journal-title":"Nat Rev Nephrology."},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30045-3","article-title":"Global, regional, and national burden of chronic kidney disease, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"395","author":"Chronic Kidney Disease Collaboration","year":"2020","journal-title":"Lancet (London England)."},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32977-0","article-title":"The global burden of chronic kidney disease","volume":"395","author":"Cockwell","year":"2020","journal-title":"Lancet (London England)."},{"key":"B5","doi-asserted-by":"publisher","first-page":"414","DOI":"10.2471\/BLT.17.206441","article-title":"The global burden of kidney disease and the sustainable development goals","volume":"96","author":"Luyckx","year":"2018","journal-title":"Bull World Health Organ"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1172\/JCI148277","article-title":"Circadian rhythms and renal pathophysiology","volume":"132","author":"Mohandas","year":"2022","journal-title":"J Clin Invest"},{"key":"B7","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1186\/s40557-018-0279-z","article-title":"The association between shift work and chronic kidney disease in manual labor workers using data from the Korea National Health and Nutrition Examination Survey (KNHANES 2011-2014)","volume":"30","author":"Uhm","year":"2018","journal-title":"Ann Occup Environ Med"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2020.09.003","article-title":"The associations of shift work, sleep quality, and incidence of hypertension in ontario adults: A population-based study","volume":"37","author":"Rahim","year":"2021","journal-title":"Can J Cardiol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"e47912","DOI":"10.7759\/cureus.47912","article-title":"Cardiovascular event predictors in hospitalized chronic kidney disease (CKD) patients: A nationwide inpatient sample analysis","volume":"15","author":"Uwumiro","year":"2023","journal-title":"Cureus."},{"key":"B10","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1038\/s41581-024-00848-8","article-title":"Sleep disorders in chronic kidney disease","volume":"20","author":"Lyons","year":"2024","journal-title":"Nat Rev Nephrology."},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-021-00518-z","article-title":"Patient-centred approaches for the management of unpleasant symptoms in kidney disease","volume":"18","author":"Kalantar-Zadeh","year":"2022","journal-title":"Nat Rev Nephrology."},{"key":"B12","doi-asserted-by":"publisher","first-page":"Cd012625","DOI":"10.1002\/14651858.CD012625.pub2","article-title":"Interventions for improving sleep quality in people with chronic kidney disease","volume":"5","author":"Natale","year":"2019","journal-title":". 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