{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:28:05Z","timestamp":1753892885802,"version":"3.41.2"},"reference-count":35,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:00:00Z","timestamp":1749513600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Depressive\/anxiety symptoms are common in subjective cognitive decline (SCD) and may relate to Alzheimer\u2019s pathology, potentially modulated by personality characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Depressive\/anxiety symptoms were assessed over 4 \u00b1 2 years in 329 SCD (88 amyloid-positive\/241 amyloid-negative) using Geriatric Depression Scale-15 (GDS), Center for Epidemiological Studies-Depression (CES-D), and Hospital Anxiety and Depression Scale-Anxiety (HADS-A). Mixed-effects models assessed associations between amyloid status and these symptoms, with neuroticism and somatization as effect-modifiers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Amyloid status was not directly associated with GDS, CES-D or HADS-A. However, neuroticism modified the association between amyloid status and GDS (p&amp;lt;0.05). In lower neuroticism, amyloid positivity was associated with GDS increase (\u03b2:0.10 \u00b1 0.08), but not in higher neuroticism (\u03b2:-0.04 \u00b1 0.12). Somatization modified the association between amyloid status and CES-D (p&amp;lt;0.05). In lower somatization, amyloid positivity was associated with CES-D increase (\u03b2:0.65 \u00b1 0.23), but not in higher somatization (\u03b2:-0.12 \u00b1 0.29).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Amyloid-positive individuals with lower neuroticism\/somatization increased more in depressive symptoms over time, suggesting a preclinical AD-related depressive phenotype.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpsyt.2025.1572174","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T05:23:39Z","timestamp":1749533019000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Longitudinal associations between amyloid and symptoms of depression and anxiety in subjective cognitive decline: the impact of personality characteristics"],"prefix":"10.3389","volume":"16","author":[{"given":"Calvin","family":"Trieu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mardou S. S. A.","family":"van Leeuwenstijn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa-Marie","family":"Schl\u00fcter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jarith L.","family":"Ebenau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inge M. W.","family":"Verberk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sietske A. M.","family":"Sikkes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sander C. J.","family":"Verfaillie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elsmarieke","family":"van de Giessen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte E.","family":"Teunissen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wiesje M.","family":"van der Flier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Argonde C.","family":"van Harten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,6,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.01.001","article-title":"A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer\u2019s disease","volume":"10","author":"Jessen","year":"2014","journal-title":"Alzheimers Dement"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12512","article-title":"Characteristics of subjective cognitive decline associated with amyloid positivity","volume":"18","author":"Janssen","year":"2022","journal-title":"Alzheimers Dement"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2013.01.059","article-title":"Neuroticism (Not depressive symptoms) predicts memory complaints in some community-dwelling older adults","volume":"21","author":"Merema","year":"2013","journal-title":"Am J Geriatr Psychiatry"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2013.04.004","article-title":"Demographic, clinical, and lifestyle correlates of subjective memory complaints in the Australian population","volume":"22","author":"Mewton","year":"2014","journal-title":"Am J Geriatr Psychiatry"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13859","article-title":"Revised criteria for diagnosis and staging of Alzheimer\u2019s disease: Alzheimer\u2019s association workgroup","volume":"20","author":"Jack","year":"2024","journal-title":"Alzheimers Dement"},{"key":"B6","doi-asserted-by":"publisher","first-page":"87","DOI":"10.3233\/jad-220319","article-title":"Subjective cognitive decline: is a resilient personality protective against progression to objective cognitive impairment? Findings from two community-based cohort studies","volume":"89","author":"Aschwanden","year":"2022","journal-title":"J Alzheimers Dis"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.1016\/j.jamda.2023.05.011","article-title":"Changes in personality before and during cognitive impairment","volume":"24","author":"Terracciano","year":"2023","journal-title":"J Am Med Dir Assoc"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2021.08.021","article-title":"Personality associations with amyloid and tau: results from the baltimore longitudinal study of aging and meta-analysis","volume":"91","author":"Terracciano","year":"2022","journal-title":"Biol Psychiatry"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.0000000000012598","article-title":"Neuropsychiatric and cognitive symptoms across the Alzheimer disease clinical spectrum: cross-sectional and longitudinal associations","volume":"97","author":"Eikelboom","year":"2021","journal-title":"Neurology"},{"key":"B10","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1212\/WNL.0000000000001238","article-title":"Noncognitive\u201d Symptoms of early alzheimer disease","volume":"84","author":"Masters","year":"2015","journal-title":"Neurology"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-200882","article-title":"Distinct profile differences in subjective cognitive decline in the general public are associated with metacognition, negative affective symptoms, neuroticism, stress, and poor quality of life","volume":"80","author":"Jenkins","year":"2021","journal-title":"J Alzheimer\u2019s Dis"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1097\/wad.0000000000000427","article-title":"Mild Alzheimer disease, financial capacity, and the role of depression: eyes wide shut","volume":"35","author":"Giannouli","year":"2021","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1080\/07317115.2021.2017377","article-title":"Longitudinal study of depression on amnestic mild cognitive impairment and financial capacity","volume":"45","author":"Giannouli","year":"2022","journal-title":"Clin Gerontol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1186\/s40035-021-00236-3","article-title":"Associations of at(N) biomarkers with neuropsychiatric symptoms in preclinical Alzheimer\u2019s disease and cognitively unimpaired individuals","volume":"10","author":"Ng","year":"2021","journal-title":"Transl Neurodegener"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1017\/s1041610217002368","article-title":"Depressive and anxiety symptoms and cortical amyloid deposition among cognitively normal elderly persons: the mayo clinic study of aging","volume":"30","author":"Krell-Roesch","year":"2018","journal-title":"Int Psychogeriatr"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12007","article-title":"Mild behavioral impairment is associated with B-amyloid but not tau or neurodegeneration in cognitively intact elderly individuals","volume":"16","author":"Lussier","year":"2020","journal-title":"Alzheimers Dement"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12352","article-title":"Neurobiological correlates of depressive symptoms in people with subjective and mild cognitive impairment","volume":"131","author":"Auning","year":"2015","journal-title":"Acta Psychiatr Scand"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12785","article-title":"Disentangling the relationship of subjective cognitive decline and depressive symptoms in the development of cognitive decline and dementia","volume":"19","author":"Kleineidam","year":"2023","journal-title":"Alzheimers Dement"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.899158","article-title":"Depressive symptoms have distinct relationships with neuroimaging biomarkers across the Alzheimer\u2019s clinical continuum","volume":"14","author":"Moulinet","year":"2022","journal-title":"Front Aging Neurosci"},{"key":"B20","doi-asserted-by":"publisher","first-page":"glad216","DOI":"10.1093\/gerona\/glad216","article-title":"Biomarkers of Alzheimer\u2019s disease and cerebrovascular disease in relation to depressive symptomatology in individuals with subjective cognitive decline","volume":"79","author":"Zapater-Fajar\u00ed","year":"2023","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2012.12.001","article-title":"Neuropsychiatric symptoms in Alzheimer\u2019s disease: past progress and anticipation of the future","volume":"9","author":"Geda","year":"2013","journal-title":"Alzheimers Dement"},{"key":"B22","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/s13024-021-00456-1","article-title":"Brain mechanisms underlying neuropsychiatric symptoms in Alzheimer\u2019s disease: A systematic review of symptom-general and -specific lesion patterns","volume":"16","author":"Chen","year":"2021","journal-title":"Mol Neurodegener"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3233\/jad-180810","article-title":"Subjective cognitive impairment in 55-65-year-old adults is associated with negative affective symptoms, neuroticism, and poor quality of life","volume":"67","author":"Jenkins","year":"2019","journal-title":"J Alzheimers Dis"},{"key":"B24","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1186\/s13195-018-0390-y","article-title":"Subjective cognitive impairment cohort (Science): study design and first results","volume":"10","author":"Slot","year":"2018","journal-title":"Alzheimer\u2019s Res Ther"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000009724","article-title":"Atn classification and clinical progression in subjective cognitive decline","volume":"95","author":"Ebenau","year":"2020","journal-title":"Neurology"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2017.281055","article-title":"Unbiased approach to counteract upward drift in cerebrospinal fluid amyloid-B 1\u201342 analysis results","volume":"64","author":"Tijms","year":"2018","journal-title":"Clin Chem"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12182","article-title":"Comparing csf amyloid-beta biomarker ratios for two automated immunoassays, elecsys and lumipulse, with amyloid pet status","volume":"13","author":"Willemse","year":"2021","journal-title":"Alzheimers Dement (Amst)"},{"key":"B28","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1177\/014662167700100306","article-title":"The ces-D scale: A self-report depression scale for research in the general population","volume":"1","author":"Radloff","year":"1977","journal-title":"Appl psychol Measure"},{"key":"B29","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/0022-3956(82)90033-4","article-title":"Development and validation of a geriatric depression screening scale: A preliminary report","volume":"17","author":"Yesavage","year":"1982","journal-title":"J Psychiatr Res"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1983.tb09716.x","article-title":"The hospital anxiety and depression scale","volume":"67","author":"Zigmond","year":"1983","journal-title":"Acta Psychiatr Scand"},{"article-title":"Manual for the Dutch personality questionnaire (Handleiding bij de npv)","year":"1985","author":"Luteijn","key":"B31"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1186\/1471-244x-6-34","article-title":"The four-dimensional symptom questionnaire (4dsq): A validation study of a multidimensional self-report questionnaire to assess distress, depression, anxiety and somatization","volume":"6","author":"Terluin","year":"2006","journal-title":"BMC Psychiatry"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1177\/1533317513504817","article-title":"Subjective memory complaints, cognitive performance, and psychological factors in healthy older adults","volume":"28","author":"Steinberg","year":"2013","journal-title":"Am J Alzheimers Dis Other Demen"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2015.07.007","article-title":"Somatisation as a risk factor for incident depression and anxiety","volume":"79","author":"Dijkstra-Kersten","year":"2015","journal-title":"J Psychosomatic Res"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291717000253","article-title":"Who pays the price for high neuroticism? Moderators of longitudinal risks for depression and anxiety","volume":"47","author":"Vittengl","year":"2017","journal-title":"psychol Med"}],"container-title":["Frontiers in Psychiatry"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpsyt.2025.1572174\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T05:23:39Z","timestamp":1749533019000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpsyt.2025.1572174\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,10]]},"references-count":35,"alternative-id":["10.3389\/fpsyt.2025.1572174"],"URL":"https:\/\/doi.org\/10.3389\/fpsyt.2025.1572174","relation":{},"ISSN":["1664-0640"],"issn-type":[{"type":"electronic","value":"1664-0640"}],"subject":[],"published":{"date-parts":[[2025,6,10]]},"article-number":"1572174"}}