{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:37:36Z","timestamp":1792683456676,"version":"4.5.0"},"reference-count":329,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T00:00:00Z","timestamp":1748476800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:p>Depression represents a global health challenge with complex etiology and significant societal impact. Recent advancements reveal a critical role of lipid metabolism dysregulation in the pathogenesis and severity of depressive disorders. This review elucidates the impact of lipid imbalance on depression highlighting how dyslipidemia not only makes individuals prone to depression but also exacerbates the progression of depression (including the occurrence of some comorbidities of depression). On this basis, we have summarized that abnormal lipid metabolism may serve as a diagnostic and therapeutic target for depression. We discuss the perturbation of lipid homeostasis in depression, marked by altered triglycerides and high-density lipoprotein levels, and the potential of these lipids as biomarkers for diagnostic precision and therapeutic efficacy. Special emphasis is placed on the molecular mechanisms where lipids influence neuronal function and stress responses, thereby affecting mood and cognitive outcomes. Furthermore, we explore the comorbidity of depression with other systemic illnesses, suggesting a shared lipid-mediated metabolic pathway. Given the integral role of lipids in neural architecture and signaling, targeting lipid metabolism could offer novel therapeutic avenues, enhancing neuroplasticity and potentially mitigating depressive symptoms. Our synthesis aims to pave the way for future investigations into lipid-centric strategies to combat depression, advocating for a metabolic reorientation in mental health therapeutics.<\/jats:p>","DOI":"10.3389\/fpsyt.2025.1589663","type":"journal-article","created":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T17:29:54Z","timestamp":1748539794000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":20,"title":["Abnormalities of lipid metabolism in the progression and treatment of depression"],"prefix":"10.3389","volume":"16","author":[{"given":"Xinchi","family":"Luan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuezhe","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoyi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijiao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyi","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruolan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianming","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyun","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,5,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-clinpsy-072220-021440","article-title":"Major depression and its recurrences: life course matters","volume":"18","author":"Monroe","year":"2022","journal-title":"Annu Rev Clin Psychol"},{"key":"B2","volume-title":"Depression","year":"2023"},{"key":"B3","volume-title":"Global Health Data Exchange (GHDx)","year":"2024"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3390\/cells10061283","article-title":"Major depression: one brain, one disease, one set of intertwined processes","volume":"10","author":"Filatova","year":"2021","journal-title":"Cells"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1080\/14737159.2018.1470927","article-title":"Blood biomarkers and treatment response in major depression","volume":"18","author":"Mora","year":"2018","journal-title":"Expert Rev Mol diagnostics"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60602-8","article-title":"Major depressive disorder: new clinical, neurobiological, and treatment perspectives","volume":"379","author":"Kupfer","year":"2012","journal-title":"Lancet (London England)"},{"key":"B7","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1097\/YCO.0000000000000379","article-title":"Major depression and its treatment: microRNAs as peripheral biomarkers of diagnosis and treatment response","volume":"31","author":"Lopez","year":"2018","journal-title":"Curr Opin Psychiatry"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2024.12.012","article-title":"Stearic acid metabolism in human health and disease","volume":"44","author":"Shen","year":"2025","journal-title":"Clin Nutr."},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-021-00354-w","article-title":"MicroRNA-mediated regulation of glucose and lipid metabolism","volume":"22","author":"Agbu","year":"2021","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"101235","DOI":"10.1016\/j.plipres.2023.101235","article-title":"Lipid metabolism around the body clocks","volume":"91","author":"Petrenko","year":"2023","journal-title":"Prog Lipid Res"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.16029","article-title":"Chronic unpredictable mild stress promotes atherosclerosis via adipose tissue dysfunction in ApoE(-\/-) mice","volume":"11","author":"Mao","year":"2023","journal-title":"PeerJ"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0b013e318274d30f","article-title":"Longitudinal relationship of depressive and anxiety symptoms with dyslipidemia and abdominal obesity","volume":"75","author":"van Reedt Dortland","year":"2013","journal-title":"Psychosomatic Med"},{"key":"B13","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.jpsychires.2018.06.007","article-title":"How lipids may affect risk for suicidal behavior","volume":"104","author":"Daray","year":"2018","journal-title":"J Psychiatr Res"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.3c00823","article-title":"Serotonin signaling through lipid membranes","volume":"15","author":"Kalinichenko","year":"2024","journal-title":"ACS Chem Neurosci"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26102838","article-title":"The effects of statins on neurotransmission and their neuroprotective role in neurological and psychiatric disorders","volume":"26","author":"Kosowski","year":"2021","journal-title":"Molecules (Basel Switzerland)"},{"key":"B16","doi-asserted-by":"publisher","first-page":"106851","DOI":"10.1016\/j.nbd.2025.106851","article-title":"Glycosphingolipids in neurodegeneration - Molecular mechanisms, cellular roles, and therapeutic perspectives","volume":"207","author":"H\u00fclsmeier","year":"2025","journal-title":"Neurobiol Dis"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1111\/cns.14497","article-title":"Neurological and metabolic related pathophysiologies and treatment of comorbid diabetes with depression","volume":"30","author":"Li","year":"2024","journal-title":"CNS Neurosci Ther"},{"key":"B18","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1080\/27697061.2023.2203235","article-title":"Pathogenesis of neurodegenerative diseases and the protective role of natural bioactive components","volume":"43","author":"Samanta","year":"2024","journal-title":"J Am Nutr Assoc"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-017-0888-1","article-title":"Dyslipidemia as a potential moderator of the association between hearing loss and depressive symptoms","volume":"21","author":"Andreeva","year":"2017","journal-title":"J nutrition Health Aging"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1177\/0091217417749786","article-title":"State-dependent alterations of lipid profiles in patients with bipolar disorder","volume":"53","author":"Huang","year":"2018","journal-title":"Int J Psychiatry Med"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.encep.2017.03.008","article-title":"Dyslipidemia and suicidal risk in patients with psychiatric disorders","volume":"44","author":"Messaoud","year":"2018","journal-title":"L\u2019Encephale"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2019.01.010","article-title":"LDL cholesterol relates to depression, its severity, and the prospective course","volume":"92","author":"Wagner","year":"2019","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2013.06.003","article-title":"Increased risk of hyperlipidemia in patients with major depressive disorder: a population-based study","volume":"75","author":"Chien","year":"2013","journal-title":"J psychosomatic Res"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2013.113","article-title":"HDL cholesterol and the risk of depression over 5 years","volume":"19","author":"Almeida","year":"2014","journal-title":"Mol Psychiatry"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.03.018","article-title":"A meta-analytic review of polyunsaturated fatty acid compositions in patients with depression","volume":"68","author":"Lin","year":"2010","journal-title":"Biol Psychiatry"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.04.011","article-title":"Gender and genotype modulation of the association between lipid levels and depressive symptomatology in community-dwelling elderly (the ESPRIT study)","volume":"68","author":"Ancelin","year":"2010","journal-title":"Biol Psychiatry"},{"key":"B27","doi-asserted-by":"publisher","first-page":"Cd004692","DOI":"10.1002\/14651858.CD004692.pub5","article-title":"Omega-3 fatty acids for depression in adults","volume":"11","author":"Appleton","year":"2021","journal-title":"Cochrane Database systematic Rev"},{"key":"B28","doi-asserted-by":"publisher","first-page":"313570","DOI":"10.1155\/2014\/313570","article-title":"Omega-3 fatty acids and depression: scientific evidence and biological mechanisms","volume":"2014","author":"Grosso","year":"2014","journal-title":"Oxid Med Cell Longevity"},{"key":"B29","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.semcdb.2017.12.003","article-title":"Significance and regulation of lipid metabolism","volume":"81","author":"DeBose-Boyd","year":"2018","journal-title":"Semin Cell Dev Biol"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25168675","article-title":"Omega-3 polyunsaturated fatty acids in depression","volume":"25","author":"Serefko","year":"2024","journal-title":"Int J Mol Sci"},{"key":"B31","doi-asserted-by":"publisher","first-page":"111143","DOI":"10.1016\/j.brainresbull.2024.111143","article-title":"Exploring the association between BDNF related signaling pathways and depression: A literature review","volume":"220","author":"Fan","year":"2025","journal-title":"Brain Res Bull"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2013.01.013","article-title":"Relationship between the hypothalamic-pituitary-adrenal-axis and fatty acid metabolism in recurrent depression","volume":"38","author":"Mocking","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.psyneuen.2015.04.027","article-title":"Fatty acid metabolism and its longitudinal relationship with the hypothalamic-pituitary-adrenal axis in major depression: Associations with prospective antidepressant response","volume":"59","author":"Mocking","year":"2015","journal-title":"Psychoneuroendocrinology"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0000000000000749","article-title":"Depression and cardiovascular disease","volume":"32","author":"Hare","year":"2021","journal-title":"Curr Opin lipidol"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.MR0119-023R","article-title":"The interplay between depression and tuberculosis","volume":"106","author":"Zhang","year":"2019","journal-title":"J leukocyte Biol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"155560","DOI":"10.1016\/j.phymed.2024.155560","article-title":"Quercetin inhibits neuronal Ferroptosis and promotes immune response by targeting lipid metabolism-related gene PTGS2 to alleviate breast cancer-related depression","volume":"130","author":"Zhu","year":"2024","journal-title":"Phytomed: Int J phytother phytopharmacol"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2021.02.003","article-title":"Lipidomics reveals that acupuncture modulates the lipid metabolism and inflammatory interaction in a mouse model of depression","volume":"94","author":"Jung","year":"2021","journal-title":"Brain behavior Immun"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26062722","article-title":"Neuroprotection vs. Neurotoxicity: the dual impact of brain lipids in depression","volume":"26","author":"Yan","year":"2025","journal-title":"Int J Mol Sci"},{"key":"B39","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1186\/s12944-025-02512-x","article-title":"Lipidomics and genomics in mental health: insights into major depressive disorder, bipolar disorder, schizophrenia, and obsessive-compulsive disorder","volume":"24","author":"Modesti","year":"2025","journal-title":"Lipids Health Dis"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2009.02.033","article-title":"Sex differences in psychopathology: of gonads, adrenals and mental illness","volume":"97","author":"Solomon","year":"2009","journal-title":"Physiol Behav"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06265-4","article-title":"Gut microbial fatty acid isomerization modulates intraepithelial T cells","volume":"619","author":"Song","year":"2023","journal-title":"Nature"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.303035","article-title":"Inhibition of nitric oxide synthase aggravates brain injury in diabetic rats with traumatic brain injury","volume":"16","author":"Yang","year":"2021","journal-title":"Neural Regener Res"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1970.01740270024003","article-title":"Plasma free fatty acids concentration in depressive illness","volume":"22","author":"Mueller","year":"1970","journal-title":"Arch Gen Psychiatry"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2024.04.005","article-title":"High-fat diet consumption promotes adolescent neurobehavioral abnormalities and hippocampal structural alterations via microglial overactivation accompanied by an elevated serum free fatty acid concentration","volume":"119","author":"Yao","year":"2024","journal-title":"Brain behavior Immun"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-023-00756-4","article-title":"Loss of fatty acid degradation by astrocytic mitochondria triggers neuroinflammation and neurodegeneration","volume":"5","author":"Mi","year":"2023","journal-title":"Nat Metab"},{"key":"B46","doi-asserted-by":"publisher","first-page":"108572","DOI":"10.1016\/j.celrep.2020.108572","article-title":"ApoE4 impairs neuron-astrocyte coupling of fatty acid metabolism","volume":"34","author":"Qi","year":"2021","journal-title":"Cell Rep"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.10.016","article-title":"Adipose-specific deletion of TFAM increases mitochondrial oxidation and protects mice against obesity and insulin resistance","volume":"16","author":"Vernochet","year":"2012","journal-title":"Cell Metab"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27072344","article-title":"Rhein improves renal fibrosis by restoring cpt1a-mediated fatty acid oxidation through sirT1\/STAT3\/twist1 pathway","volume":"27","author":"Song","year":"2022","journal-title":"Molecules (Basel Switzerland)"},{"key":"B49","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1016\/j.cell.2024.02.024","article-title":"A gut-derived hormone regulates cholesterol metabolism","volume":"187","author":"Hu","year":"2024","journal-title":"Cell"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)92556-9","article-title":"Plasma cholesterol and depressive symptoms in older men","volume":"341","author":"Morgan","year":"1993","journal-title":"Lancet"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2017.02.002","article-title":"Serum lipid levels in depression and suicidality: The Korea National Health and Nutrition Examination Survey (KNHANES) 2014","volume":"213","author":"Oh","year":"2017","journal-title":"J Affect Disord"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2004.11.005","article-title":"Serum lipid profiles in major depression with clinical subtypes, suicide attempts and episodes","volume":"86","author":"Huang","year":"2005","journal-title":"J Affect Disord"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.14m09505","article-title":"Longitudinal study of low serum LDL cholesterol and depressive symptom onset in postmenopause","volume":"77","author":"Persons","year":"2016","journal-title":"J Clin Psychiatry"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2021.306517","article-title":"The national health and nutrition examination survey (NHANES), 2021-2022: adapting data collection in a COVID-19 environment","volume":"111","author":"Paulose-Ram","year":"2021","journal-title":"Am J Public Health"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.3390\/nu11112582","article-title":"The association between sleep duration and metabolic syndrome: the NHANES 2013\/2014","volume":"11","author":"Smiley","year":"2019","journal-title":"Nutrients"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.3122\/jabfm.2011.01.100121","article-title":"Prevalence, treatment, and control of depressive symptoms in the United States: results from the National Health and Nutrition Examination Survey (NHANES), 2005-2008","volume":"24","author":"Shim","year":"2011","journal-title":"J Am Board Fam Med"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.202010053","article-title":"Silencing the spindle assembly checkpoint: Let\u2019s play Polo","volume":"219","author":"Benzi","year":"2020","journal-title":"J Cell Biol"},{"key":"B58","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/s12944-022-01645-7","article-title":"Low cholesterol is not associated with depression: data from the 2005\u20132018 National Health and Nutrition Examination Survey","volume":"21","author":"Zhang","year":"2022","journal-title":"Lipids Health Dis"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2005.09.015","article-title":"Leptin and cholesterol levels are low in major depressive disorder, but high in schizophrenia","volume":"90","author":"Jow","year":"2006","journal-title":"J Affect Disord"},{"key":"B60","first-page":"1","article-title":"National Health and Nutrition Examination Survey: estimation procedures, 2007-2010","volume":"2","author":"Mirel","year":"2013","journal-title":"Vital Health Stat"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1080\/08039488.2019.1664630","article-title":"Characterological depression in patients with narcissistic personality disorder","volume":"73","author":"Fjermestad-Noll","year":"2019","journal-title":"Nordic J Psychiatry"},{"key":"B62","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1186\/s12888-025-06734-2","article-title":"Lipid profiles in major depression, both with and without metabolic syndrome: associations with suicidal behaviors and neuroticism","volume":"25","author":"Jirakran","year":"2025","journal-title":"BMC Psychiatry"},{"key":"B63","doi-asserted-by":"publisher","first-page":"53","DOI":"10.4103\/ijcm.ijcm_490_23","article-title":"Is physical activity related to depression and anxiety among adults? Observations from a noncommunicable disease screening clinic in north India","volume":"50","author":"Verma","year":"2025","journal-title":"Indian J Community Med"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2020.06.001","article-title":"Low levels of cholesterol and the cholesterol type are not associated with depression: Results of a cross-sectional NHANES study","volume":"14","author":"Cepeda","year":"2020","journal-title":"J Clin Lipidol"},{"key":"B65","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/s12160-008-9045-8","article-title":"Are cholesterol and depression inversely related? A meta-analysis of the association between two cardiac risk factors","volume":"36","author":"Shin","year":"2008","journal-title":"Ann Behav Med"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07387-z","article-title":"Discovery of potent small-molecule inhibitors of lipoprotein(a) formation","volume":"629","author":"Diaz","year":"2024","journal-title":"Nature"},{"key":"B67","doi-asserted-by":"publisher","first-page":"108684","DOI":"10.1016\/j.pharmthera.2024.108684","article-title":"HDL-based therapeutics: A promising frontier in combating viral and bacterial infections","volume":"260","author":"Rani","year":"2024","journal-title":"Pharmacol Ther"},{"key":"B68","doi-asserted-by":"publisher","first-page":"76396","DOI":"10.1155\/2007\/76396","article-title":"Pro- and anti-inflammatory cytokine balance in major depression: effect of sertraline therapy","volume":"2007","author":"Sutcigil","year":"2007","journal-title":"Clin Dev Immunol"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2008.05.021","article-title":"Low HDL cholesterol associates with major depression in a sample with a 7-year history of depressive symptoms","volume":"32","author":"Lehto","year":"2008","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1819.2010.02079.x","article-title":"Low serum HDL-cholesterol levels are associated with long symptom duration in patients with major depressive disorder","volume":"64","author":"Lehto","year":"2010","journal-title":"Psychiatry Clin Neurosci"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2021.02.037","article-title":"The role of high-density lipoprotein cholesterol, apolipoprotein A and paraoxonase-1 in the pathophysiology of neuroprogressive disorders","volume":"125","author":"Morris","year":"2021","journal-title":"Neurosci Biobehav Rev"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1101\/2024.01.01.24300688","article-title":"First-episode mild depression in young adults is a pre-proatherogenic condition even in the absence of subclinical metabolic syndrome: lowered lecithin-cholesterol acyltransferase as a key factor","volume":"45","author":"Maes","year":"2024","journal-title":"Neuro Endocrinol Lett"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-003-2021-7","article-title":"HDL-cholesterol level and cortisol response to synacthen in critically ill patients","volume":"29","author":"van der Voort","year":"2003","journal-title":"Intensive Care Med"},{"key":"B74","doi-asserted-by":"publisher","first-page":"57","DOI":"10.5607\/en23010","article-title":"Impaired cholesterol metabolism, neurons, and neuropsychiatric disorders","volume":"32","author":"Cheon","year":"2023","journal-title":"Exp Neurobiol"},{"key":"B75","doi-asserted-by":"publisher","first-page":"105741","DOI":"10.1016\/j.neubiorev.2024.105741","article-title":"Neurolipidomic insights into anxiety disorders: Uncovering lipid dynamics for potential therapeutic advances","volume":"163","author":"Maehashi","year":"2024","journal-title":"Neurosci Biobehav Rev"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.700847","article-title":"Understanding the exchange of systemic HDL particles into the brain and vascular cells has diagnostic and therapeutic implications for neurodegenerative diseases","volume":"12","author":"Van Valkenburgh","year":"2021","journal-title":"Front Physiol"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25126607","article-title":"Interactions of serum amyloid A proteins with the blood-brain barrier: implications for central nervous system disease","volume":"25","author":"Erickson","year":"2024","journal-title":"Int J Mol Sci"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.125.326462","article-title":"MAIT cells in lipoprotein metabolism: A new pathway for VLDL clearance","volume":"136","author":"Syed-Abdul","year":"2025","journal-title":"Circ Res"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2025.03.102","article-title":"Clinical correlates, lipid metabolic parameters and thyroid hormones are associated with abnormal glucose metabolism in first-episode and drug-na\u00efve major depressive disorder patients with suicide attempts: A large cross-sectional study","volume":"380","author":"Chen","year":"2025","journal-title":"J Affect Disord"},{"key":"B80","doi-asserted-by":"publisher","first-page":"7115559","DOI":"10.1155\/2024\/7115559","article-title":"Depressive symptoms and metabolic dysregulation control: A closer look at control challenges in T2DM patients","volume":"2024","author":"Yang","year":"2024","journal-title":"Depression Anxiety"},{"key":"B81","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1186\/s12888-024-06168-2","article-title":"Relationship between thyroid-stimulating hormone and blood lipids in patients with first-episode depression","volume":"24","author":"Cui","year":"2024","journal-title":"BMC Psychiatry"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibneur.2025.01.004","article-title":"Lipidopathy disrupts peripheral and central amyloid clearance in Alzheimer\u2019s disease: Where are our knowledge","volume":"18","author":"Darabi","year":"2025","journal-title":"IBRO Neurosci Rep"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(23)00156-0","article-title":"Lipoprotein(a) and carotid intima-media thickness in children with familial hypercholesterolaemia in the Netherlands: a 20-year follow-up study","volume":"11","author":"de Boer","year":"2023","journal-title":"Lancet Diabetes Endocrinol"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2015.04.004","article-title":"Levels of triglycerides, cholesterol, LDL, HDL and glucose in patients with schizophrenia, unipolar depression and bipolar disorder","volume":"9","author":"Wysoki\u0144ski","year":"2015","journal-title":"Diabetes Metab Syndr"},{"key":"B85","article-title":"Levels of serum total cholesterol and LDL-cholesterol in patients with major depression in acute period and remission","volume":"6","author":"Rabe-Jab\u0142o\u0144ska","year":"2000","journal-title":"Med Sci Monit"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.30773\/pi.2019.03.24","article-title":"The association between depressive mood and cholesterol levels in Korean adolescents","volume":"16","author":"Kim","year":"2019","journal-title":"Psychiatry Invest"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1161\/01.atv.21.2.282","article-title":"Atherogenic role of elevated CE transfer from HDL to VLDL(1) and dense LDL in type 2 diabetes: impact of the degree of triglyceridemia","volume":"21","author":"Gu\u00e9rin","year":"2001","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2014.05.008","article-title":"Triglyceride-lowering agents","volume":"22","author":"Salakhutdinov","year":"2014","journal-title":"Bioorg Med Chem"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02222-w","article-title":"Evinacumab in severe hypertriglyceridemia with or without lipoprotein lipase pathway mutations: a phase 2 randomized trial","volume":"29","author":"Rosenson","year":"2023","journal-title":"Nat Med"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2016.03.001","article-title":"Association between serum triglycerides and cerebral amyloidosis in cognitively normal elderly","volume":"24","author":"Choi","year":"2016","journal-title":"Am J Geriatr Psychiatry"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1819.2004.01235.x","article-title":"Lipid and lipoprotein levels in depressive disorders with melancholic feature or atypical feature and dysthymia","volume":"58","author":"Huang","year":"2004","journal-title":"Psychiatry Clin Neurosci"},{"key":"B92","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1177\/070674370104600110","article-title":"Serum lipid concentrations in patients with comorbid generalized anxiety disorder and major depressive disorder","volume":"46","author":"Sevincok","year":"2001","journal-title":"Can J Psychiatry"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-016-9768-5","article-title":"Plasma lipidomics reveals potential lipid markers of major depressive disorder","volume":"408","author":"Liu","year":"2016","journal-title":"Anal Bioanal Chem"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1002\/gps.v19:3","article-title":"The relationship between cholesterol levels and depression in the elderly","volume":"19","author":"Erg\u00fcn","year":"2004","journal-title":"Int J Geriatr Psychiatry"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(95)00599-4","article-title":"Serum lipid concentrations in patients with major depressive disorder","volume":"40","author":"Olusi","year":"1996","journal-title":"Biol Psychiatry"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.4525","article-title":"Metabolic profile and long-term risk of depression, anxiety, and stress-related disorders","volume":"7","author":"Chourpiliadis","year":"2024","journal-title":"JAMA network Open"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2017.03.007","article-title":"Elevated triglyceride levels are associated with cognitive impairments among patients with major depressive disorder","volume":"75","author":"Shao","year":"2017","journal-title":"Compr Psychiatry"},{"key":"B98","doi-asserted-by":"publisher","first-page":"105582","DOI":"10.1016\/j.neubiorev.2024.105582","article-title":"The importance of assessing the triglyceride-glucose index (TyG) in patients with depression: A systematic review","volume":"159","author":"Behnoush","year":"2024","journal-title":"Neurosci biobehavioral Rev"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1093\/nutrit\/nuab118","article-title":"Role of ketone bodies in diabetes-induced dementia: sirtuins, insulin resistance, synaptic plasticity, mitochondrial dysfunction, and neurotransmitter","volume":"80","author":"Chung","year":"2022","journal-title":"Nutr Rev"},{"key":"B100","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1093\/eurheartj\/ehz785","article-title":"Clinical review on triglycerides","volume":"41","author":"Laufs","year":"2020","journal-title":"Eur Heart J"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2023.1142682","article-title":"Exploring the role of ketone bodies in the diagnosis and treatment of psychiatric disorders","volume":"14","author":"Omori","year":"2023","journal-title":"Front Psychiatry"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.47626\/2237-6089-2024-0932","article-title":"Perspectives on the ketogenic diet as a non-pharmacological intervention for major depressive disorder","author":"Shelp","year":"2025","journal-title":"Trends Psychiatry Psychother"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1111\/cns.70324","article-title":"The restoration of energy pathways indicates the efficacy of ketamine treatment in depression: A metabolomic analysis","volume":"31","author":"You","year":"2025","journal-title":"CNS Neurosci Ther"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2014.2206","article-title":"Identification of a common neurobiological substrate for mental illness","volume":"72","author":"Goodkind","year":"2015","journal-title":"JAMA Psychiatry"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1096\/fba.2024-00123","article-title":"The impact of mild episodic ketosis on microglia and hippocampal long-term depression in 5xFAD mice","volume":"6","author":"Di Lucente","year":"2024","journal-title":"FASEB bioAdvances"},{"key":"B106","doi-asserted-by":"publisher","first-page":"58","DOI":"10.33160\/yam.2025.02.007","article-title":"Medium-chain triglyceride administration induces antidepressant effects in animal models by increasing beta-hydroxybutyrate levels","volume":"68","author":"Miura","year":"2025","journal-title":"Yonago Acta Med"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1002\/npr2.12099","article-title":"Prefrontal cortex infusion of beta-hydroxybutyrate, an endogenous NLRP3 inflammasome inhibitor, produces antidepressant-like effects in a rodent model of depression","volume":"40","author":"Kajitani","year":"2020","journal-title":"Neuropsychopharmacol Rep"},{"key":"B108","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.bbrc.2021.03.062","article-title":"Acutely increased \u03b2-hydroxybutyrate plays a role in the prefrontal cortex to escape stressful conditions during the acute stress response","volume":"554","author":"Son","year":"2021","journal-title":"Biochem Biophys Res Commun"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.15092","article-title":"Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body \u03b2-hydroxybutyrate","volume":"5","author":"Sleiman","year":"2016","journal-title":"eLife"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12040813","article-title":"The plasma levels of 3-hydroxybutyrate, dityrosine, and other markers of oxidative stress and energy metabolism in major depressive disorder","volume":"12","author":"Krivosova","year":"2022","journal-title":"Diagnostics (Basel Switzerland)"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2014.09.025","article-title":"Is depression associated with increased oxidative stress? A systematic review and meta-analysis","volume":"51","author":"Black","year":"2015","journal-title":"Psychoneuroendocrinology"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2014.04.005","article-title":"An updated meta-analysis of oxidative stress markers in bipolar disorder","volume":"218","author":"Brown","year":"2014","journal-title":"Psychiatry Res"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12980","article-title":"Oxidative stress parameters and antioxidants in patients with bipolar disorder: Results from a meta-analysis comparing patients, including stratification by polarity and euthymic status, with healthy controls","volume":"23","author":"Jim\u00e9nez-Fern\u00e1ndez","year":"2021","journal-title":"Bipolar Disord"},{"key":"B114","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.psychres.2007.07.019","article-title":"Increased plasma levels of 8-iso-PGF2alpha and IL-6 in an elderly population with depression","volume":"161","author":"Dimopoulos","year":"2008","journal-title":"Psychiatry Res"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1016\/S1734-1140(09)70084-2","article-title":"Lipid peroxidation and antioxidant protection in patients during acute depressive episodes and in remission after fluoxetine treatment","volume":"61","author":"Ga\u0142ecki","year":"2009","journal-title":"Pharmacol reports: PR"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2010.03.010","article-title":"Depression and oxidative damage to lipids","volume":"35","author":"Yager","year":"2010","journal-title":"Psychoneuroendocrinology"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(00)00097-3","article-title":"Lipid peroxidation, antioxidants and cardiovascular disease: how should we move forward","volume":"47","author":"Halliwell","year":"2000","journal-title":"Cardiovasc Res"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(99)00264-6","article-title":"Measurement of F(2)-isoprostanes as an index of oxidative stress in vivo","volume":"28","author":"Roberts","year":"2000","journal-title":"Free Radic Biol Med"},{"key":"B119","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/S0165-0327(00)00199-3","article-title":"Antioxidative enzyme activities and lipid peroxidation in major depression: alterations by antidepressant treatments","volume":"64","author":"Bilici","year":"2001","journal-title":"J Affect Disord"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2006.04.012","article-title":"Oxidation of apolipoprotein B-containing lipoproteins and serum paraoxonase\/arylesterase activities in major depressive disorder","volume":"30","author":"Sarandol","year":"2006","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1080\/13547500500215084","article-title":"Isoprostanes and other markers of peroxidation in atherosclerosis","author":"Patrignani","year":"2005","journal-title":"Biomarkers"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-017-1741-z","article-title":"The association of alcohol use and quality of life in depressed and non-depressed individuals: a cross-sectional general population study","volume":"27","author":"Levola","year":"2018","journal-title":"Qual Life Res"},{"key":"B123","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1007\/s12640-018-9906-2","article-title":"Generalized anxiety disorder (GAD) and comorbid major depression with GAD are characterized by enhanced nitro-oxidative stress, increased lipid peroxidation, and lowered lipid-associated antioxidant defenses","volume":"34","author":"Maes","year":"2018","journal-title":"Neurotox Res"},{"key":"B124","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/B978-0-12-024911-4.50008-8","article-title":"The metabolic role of lecithin: cholesterol acyltransferase: perspectives form pathology","volume":"11","author":"Glomset","year":"1973","journal-title":"Adv Lipid Res"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M017079","article-title":"Nascent HDL formation in hepatocytes and role of ABCA1, ABCG1, and SR-BI","volume":"53","author":"Ji","year":"2012","journal-title":"J Lipid Res"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R024513","article-title":"Lecithin:cholesterol acyltransferase: old friend or foe in atherosclerosis","volume":"53","author":"Kunnen","year":"2012","journal-title":"J Lipid Res"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2015.3930","article-title":"High-density lipoprotein synthesis and metabolism (Review)","volume":"12","author":"Zhou","year":"2015","journal-title":"Mol Med Rep"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-1981(00)00153-0","article-title":"Lecithin cholesterol acyltransferase","volume":"1529","author":"Jonas","year":"2000","journal-title":"Biochim Biophys Acta"},{"key":"B129","doi-asserted-by":"publisher","first-page":"47","DOI":"10.14797\/mdcj-15-1-47","article-title":"Revisiting reverse cholesterol transport in the context of high-density lipoprotein free cholesterol bioavailability","volume":"15","author":"Rosales","year":"2019","journal-title":"Methodist Debakey Cardiovasc J"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2023.08.007","article-title":"Reverse cholesterol transport and lipid peroxidation biomarkers in major depression and bipolar disorder: A systematic review and meta-analysis","volume":"113","author":"Almulla","year":"2023","journal-title":"Brain Behav Immun"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1994.tb01589.x","article-title":"Lower degree of esterification of serum cholesterol in depression: relevance for depression and suicide research","volume":"90","author":"Maes","year":"1994","journal-title":"Acta Psychiatr Scand"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1101\/2023.02.10.23285746","article-title":"Major depression, suicidal behaviors and neuroticism are pro-atherogenic states driven by lowered reverse cholesterol transport","author":"Jirakran","year":"2023","journal-title":"medRxiv"},{"key":"B133","doi-asserted-by":"publisher","first-page":"8563845","DOI":"10.1155\/2019\/8563845","article-title":"Targeting early atherosclerosis: A focus on oxidative stress and inflammation","volume":"2019","author":"Marchio","year":"2019","journal-title":"Oxid Med Cell Longev"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1121819","article-title":"Cholesterol metabolism in the regulation of inflammatory responses","volume":"14","author":"Bauer","year":"2023","journal-title":"Front Pharmacol"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11030540","article-title":"Antioxidant biomolecules and their potential for the treatment of difficult-to-treat depression and conventional treatment-resistant depression","volume":"11","author":"Riveros","year":"2022","journal-title":"Antioxidants (Basel)"},{"key":"B136","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.it.2005.11.006","article-title":"Cytokines sing the blues: inflammation and the pathogenesis of depression","volume":"27","author":"Raison","year":"2006","journal-title":"Trends Immunol"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.20.6.1536","article-title":"Infection and inflammation induce LDL oxidation in vivo","volume":"20","author":"Memon","year":"2000","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B138","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.biopsycho.2005.11.011","article-title":"The relation between psychological factors and DNA-damage: a critical review","volume":"72","author":"Gidron","year":"2006","journal-title":"Biol Psychol"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2005.01.009","article-title":"Depression and possible cancer risk due to oxidative DNA damage","volume":"39","author":"Irie","year":"2005","journal-title":"J Psychiatr Res"},{"key":"B140","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/01.psy.0000195780.37277.2a","article-title":"Increased serum levels of 8-hydroxy-2\u2019-deoxyguanosine in clinical depression","volume":"68","author":"Forlenza","year":"2006","journal-title":"Psychosom Med"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1007\/s12640-017-9835-5","article-title":"Lipid peroxidation and immune biomarkers are associated with major depression and its phenotypes, including treatment-resistant depression and melancholia","volume":"33","author":"Sowa-Ku\u0107ma","year":"2018","journal-title":"Neurotox Res"},{"key":"B142","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/s12031-019-01401-0","article-title":"The association of major depressive disorder with activation of NLRP3 inflammasome, lipid peroxidation, and total antioxidant capacity","volume":"70","author":"Taene","year":"2020","journal-title":"J Mol Neurosci"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202400671","article-title":"Bio-inspired carbon dots as malondialdehyde indicator for real-time visualization of lipid peroxidation in depression","author":"Wu","year":"2024","journal-title":"Small (Weinheim an der Bergstrasse Germany)"},{"key":"B144","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.jpsychires.2018.02.023","article-title":"Oxidative stress markers imbalance in late-life depression","volume":"102","author":"Diniz","year":"2018","journal-title":"J Psychiatr Res"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291716002828","article-title":"Oxidative stress in major depressive and anxiety disorders, and the association with antidepressant use; results from a large adult cohort","volume":"47","author":"Black","year":"2017","journal-title":"Psychol Med"},{"key":"B146","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.jpsychires.2021.05.036","article-title":"A systematic review and meta-analysis of lipid metabolomic signatures of Major Depressive Disorder","volume":"139","author":"Bharti","year":"2021","journal-title":"J Psychiatr Res"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1097\/01.jcp.0000138762.23482.63","article-title":"Lipid metabolism and insulin resistance in depressed patients: significance of weight, hypercortisolism, and antidepressant treatment","volume":"24","author":"Kopf","year":"2004","journal-title":"J Clin Psychopharmacol"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1080\/10673220127910","article-title":"Omega-3 fatty acids, homocysteine, and the increased risk of cardiovascular mortality in major depressive disorder","volume":"9","author":"Severus","year":"2001","journal-title":"Harv Rev Psychiatry"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1590\/S1807-59322011000100020","article-title":"Relationship between depression and apolipoproteins A and B: a case-control study","volume":"66","author":"Sadeghi","year":"2011","journal-title":"Clinics (Sao Paulo Brazil)"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1161\/atvb.36.suppl_1.391","article-title":"Abstract 391: apolipoprotein E3, apolipoprotein AI, and apolipophorin III chimeras provide insight into the domain organization of apolipoproteins","volume":"36","author":"Horn","year":"2016","journal-title":"Arteriosclerosis Thrombosis Vasc Biol"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145712000302","article-title":"Comparative proteomic analysis of plasma from major depressive patients: identification of proteins associated with lipid metabolism and immunoregulation","volume":"15","author":"Xu","year":"2012","journal-title":"Int J Neuropsychopharmacol"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1016\/S0753-3322(02)00193-2","article-title":"Polyunsaturated fatty acids (PUFA) and eicosanoids in human health and pathologies","volume":"56","author":"Tapiero","year":"2002","journal-title":"BioMed Pharmacother"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.3390\/nu9111165","article-title":"Precision nutrition and omega-3 polyunsaturated fatty acids: A case for personalized supplementation approaches for the prevention and management of human diseases","volume":"9","author":"Chilton","year":"2017","journal-title":"Nutrients"},{"key":"B154","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1016\/j.jad.2019.07.035","article-title":"Brain serotonin transporter binding, plasma arachidonic acid and depression severity: A positron emission tomography study of major depression","volume":"257","author":"Gopaldas","year":"2019","journal-title":"J Affect Disord"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v67n1217","article-title":"Omega-3 fatty acids: evidence basis for treatment and future research in psychiatry","volume":"67","author":"Freeman","year":"2006","journal-title":"J Clin Psychiatry"},{"key":"B156","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.plipres.2017.01.001","article-title":"Polyunsaturated fatty acids and recurrent mood disorders: Phenomenology, mechanisms, and clinical application","volume":"66","author":"Messamore","year":"2017","journal-title":"Prog Lipid Res"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9080850","article-title":"Mental health in childhood and adolescence: the role of polyunsaturated fatty acids","volume":"9","author":"Bozzatello","year":"2021","journal-title":"Biomedicines"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1781(99)00014-1","article-title":"Lowered omega3 polyunsaturated fatty acids in serum phospholipids and cholesteryl esters of depressed patients","volume":"85","author":"Maes","year":"1999","journal-title":"Psychiatry Res"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2014.11.018","article-title":"Decreased serum levels of polyunsaturated fatty acids and folate, but not brain-derived neurotrophic factor, in childhood and adolescent females with depression","volume":"225","author":"Tsuchimine","year":"2015","journal-title":"Psychiatry Res"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-018-0047-z","article-title":"Polyunsaturated fatty acids metabolism, purine metabolism and inosine as potential independent diagnostic biomarkers for major depressive disorder in children and adolescents","volume":"24","author":"Zhou","year":"2019","journal-title":"Mol Psychiatry"},{"key":"B161","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1097\/YCO.0b013e3282f29841","article-title":"The role of fatty acids in the development and treatment of mood disorders","volume":"21","author":"Owen","year":"2008","journal-title":"Curr Opin Psychiatry"},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2006.163.6.1098","article-title":"Omega-3 treatment of childhood depression: a controlled, double-blind pilot study","volume":"163","author":"Nemets","year":"2006","journal-title":"Am J Psychiatry"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.159.3.477","article-title":"Addition of omega-3 fatty acid to maintenance medication treatment for recurrent unipolar depressive disorder","volume":"159","author":"Nemets","year":"2002","journal-title":"Am J Psychiatry"},{"key":"B164","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.phanu.2014.02.002","article-title":"Detection and treatment of long-chain omega-3 fatty acid deficiency in adolescents with SSRI-resistant major depressive disorder","volume":"2","author":"McNamara","year":"2014","journal-title":"PharmaNutrition"},{"key":"B165","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.1010476","article-title":"Causal effects of fatty acids on depression: Mendelian randomization study","volume":"9","author":"Zeng","year":"2022","journal-title":"Front Nutr"},{"key":"B166","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1038\/s41398-019-0515-5","article-title":"Efficacy of omega-3 PUFAs in depression: A meta-analysis","volume":"9","author":"Liao","year":"2019","journal-title":"Trans Psychiatry"},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.999001","article-title":"Human gut microbiota in health and disease: Unveiling the relationship","volume":"13","author":"Afzaal","year":"2022","journal-title":"Front Microbiol"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23092375","article-title":"Targeted neurotransmitters profiling identifies metabolic signatures in rat brain by LC-MS\/MS: application in insomnia, depression and alzheimer\u2019s disease","volume":"23","author":"Xu","year":"2018","journal-title":"Molecules (Basel Switzerland)"},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.701355","article-title":"Altered fecal metabolites and colonic glycerophospholipids were associated with abnormal composition of gut microbiota in a depression model of mice","volume":"15","author":"Gong","year":"2021","journal-title":"Front Neurosci"},{"key":"B170","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/s12944-024-02056-6","article-title":"A mediation analysis of the role of total free fatty acids on pertinence of gut microbiota composition and cognitive function in late life depression","volume":"23","author":"Chen","year":"2024","journal-title":"Lipids Health Dis"},{"key":"B171","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1038\/s41398-022-01836-x","article-title":"Changes in gut viral and bacterial species correlate with altered 1,2-diacylglyceride levels and structure in the prefrontal cortex in a depression-like non-human primate model","volume":"12","author":"Wu","year":"2022","journal-title":"Trans Psychiatry"},{"key":"B172","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2022.786492","article-title":"Effects of the lipid metabolites and the gut microbiota in apoE(-\/-) mice on atherosclerosis co-depression from the microbiota-gut-brain axis","volume":"9","author":"Hu","year":"2022","journal-title":"Front Mol Biosci"},{"key":"B173","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60879-5","article-title":"Clinical diagnosis of depression in primary care: a meta-analysis","volume":"374","author":"Mitchell","year":"2009","journal-title":"Lancet"},{"key":"B174","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023881","article-title":"DNA methylation profiles of the brain-derived neurotrophic factor (BDNF) gene as a potent diagnostic biomarker in major depression","volume":"6","author":"Fuchikami","year":"2011","journal-title":"PloS One"},{"key":"B175","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.v23:5","article-title":"Acid hydrolysis followed by matrix-assisted laser desorption\/ionization mass spectrometry for the rapid diagnosis of serum protein biomarkers in patients with major depression","volume":"23","author":"Lo","year":"2009","journal-title":"Rapid Commun Mass Spectrom"},{"key":"B176","doi-asserted-by":"publisher","DOI":"10.1136\/jech.48.4.360","article-title":"Serum lipids and mood in working men and women in Sweden","volume":"48","author":"Lindberg","year":"1994","journal-title":"J Epidemiol Community Health"},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30385-3","article-title":"Comparative efficacy and tolerability of antidepressants for major depressive disorder in children and adolescents: a network meta-analysis","volume":"388","author":"Cipriani","year":"2016","journal-title":"Lancet"},{"key":"B178","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2007.06.025","article-title":"Childhood and adolescent depression: why do children and adults respond differently to antidepressant drugs","volume":"51","author":"Bylund","year":"2007","journal-title":"Neurochem Int"},{"key":"B179","doi-asserted-by":"publisher","DOI":"10.1016\/j.adolescence.2014.05.012","article-title":"The differential relation of childhood maltreatment to stress sensitization in adolescent and young adult depression","volume":"37","author":"La Rocque","year":"2014","journal-title":"J Adolesc"},{"key":"B180","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1001\/jamapsychiatry.2023.0685","article-title":"Interplay of metabolome and gut microbiome in individuals with major depressive disorder vs control individuals","volume":"80","author":"Amin","year":"2023","journal-title":"JAMA Psychiatry"},{"key":"B181","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1038\/s41380-018-0017-5","article-title":"Depression and obesity: evidence of shared biological mechanisms","volume":"24","author":"Milaneschi","year":"2019","journal-title":"Mol Psychiatry"},{"key":"B182","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-2055","article-title":"Bidirectional association between depression and metabolic syndrome: a systematic review and meta-analysis of epidemiological studies","volume":"35","author":"Pan","year":"2012","journal-title":"Diabetes Care"},{"key":"B183","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1186\/s12889-019-7322-z","article-title":"Severity of depression, anxious distress and the risk of type 2 diabetes - a population-based cohort study in Sweden","volume":"19","author":"Deleskog","year":"2019","journal-title":"BMC Public Health"},{"key":"B184","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1186\/s12889-019-7587-2","article-title":"Correction to: Severity of depression, anxious distress and the risk of type 2 diabetes - a population-based cohort study in Sweden","volume":"19","author":"Deleskog","year":"2019","journal-title":"BMC Public Health"},{"key":"B185","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2010.2","article-title":"Overweight, obesity, and depression: a systematic review and meta-analysis of longitudinal studies","volume":"67","author":"Luppino","year":"2010","journal-title":"Arch Gen Psychiatry"},{"key":"B186","doi-asserted-by":"publisher","DOI":"10.3389\/fepid.2023.1216497","article-title":"A stronger association of depression with rheumatoid arthritis in presence of obesity and hypertriglyceridemia","volume":"3","author":"Shand","year":"2023","journal-title":"Front Epidemiol"},{"key":"B187","doi-asserted-by":"publisher","first-page":"e20","DOI":"10.1016\/S2666-5247(22)00359-7","article-title":"WHO\u2019s global tuberculosis report 2022","volume":"4","author":"Bagcchi","year":"2023","journal-title":"Lancet Microbe"},{"key":"B188","doi-asserted-by":"publisher","DOI":"10.1177\/1039856216649770","article-title":"Tuberculosis and mental health in the Asia-Pacific","volume":"24","author":"Mason","year":"2016","journal-title":"Australas psychiatry: Bull R Aust New Z Coll Psychiatrists"},{"key":"B189","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000204","article-title":"Foamy macrophages from tuberculous patients\u2019 granulomas constitute a nutrient-rich reservoir for M. tuberculosis persistence","volume":"4","author":"Peyron","year":"2008","journal-title":"PloS Pathog"},{"key":"B190","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2012.09.012","article-title":"Mycobacterium tuberculosis-driven targeted recalibration of macrophage lipid homeostasis promotes the foamy phenotype","volume":"12","author":"Singh","year":"2012","journal-title":"Cell host Microbe"},{"key":"B191","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3699","article-title":"The biophysics and cell biology of lipid droplets","volume":"14","author":"Thiam","year":"2013","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B192","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-008-1397-2","article-title":"Lipolytic enzymes in Mycobacterium tuberculosis","volume":"78","author":"C\u00f4tes","year":"2008","journal-title":"Appl Microbiol Biotechnol"},{"key":"B193","doi-asserted-by":"publisher","DOI":"10.3109\/1040841X.2010.482923","article-title":"Lipid hydrolizing enzymes in virulence: Mycobacterium tuberculosis as a model system","volume":"36","author":"Singh","year":"2010","journal-title":"Crit Rev Microbiol"},{"key":"B194","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.445056","article-title":"Intracellular Mycobacterium tuberculosis exploits host-derived fatty acids to limit metabolic stress","volume":"288","author":"Lee","year":"2013","journal-title":"J Biol Chem"},{"key":"B195","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900365","article-title":"Mycobacterium bovis bacillus Calmette-Gu\u00e9rin infection induces TLR2-dependent peroxisome proliferator-activated receptor gamma expression and activation: functions in inflammation, lipid metabolism, and pathogenesis","volume":"183","author":"Almeida","year":"2009","journal-title":"J Immunol"},{"key":"B196","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1000866","article-title":"Mycobacterium tuberculosis activates human macrophage peroxisome proliferator-activated receptor gamma linking mannose receptor recognition to regulation of immune responses","volume":"185","author":"Rajaram","year":"2010","journal-title":"J Immunol"},{"key":"B197","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1103038","article-title":"Mycobacterium tuberculosis modulates macrophage lipid-sensing nuclear receptors PPAR\u03b3 and TR4 for survival","volume":"188","author":"Mahajan","year":"2012","journal-title":"J Immunol"},{"key":"B198","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1146\/annurev.immunol.20.083001.084359","article-title":"Innate immune recognition","volume":"20","author":"Janeway","year":"2002","journal-title":"Annu Rev Immunol"},{"key":"B199","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1186\/s12974-014-0166-7","article-title":"The impact of single and pairwise Toll-like receptor activation on neuroinflammation and neurodegeneration","volume":"11","author":"Rosenberger","year":"2014","journal-title":"J neuroinflammation"},{"key":"B200","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxz023","article-title":"Roles of multiple lipid mediators in stress and depression","volume":"31","author":"Furuyashiki","year":"2019","journal-title":"Int Immunol"},{"key":"B201","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S164134","article-title":"Plasma disturbance of phospholipid metabolism in major depressive disorder by integration of proteomics and metabolomics","volume":"14","author":"Gui","year":"2018","journal-title":"Neuropsychiatr Dis Treat"},{"key":"B202","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2018.05.059","article-title":"Low serum free thyroxine level is correlated with lipid profile in depressive patients with suicide attempt","volume":"266","author":"Peng","year":"2018","journal-title":"Psychiatry Res"},{"key":"B203","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3820","article-title":"Polyunsaturated fatty acids and their metabolites in brain function and disease","volume":"15","author":"Bazinet","year":"2014","journal-title":"Nat Rev Neurosci"},{"key":"B204","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2008.08.004","article-title":"Effects of omega-3 and -6 fatty acids on Mycobacterium tuberculosis in macrophages and in mice","volume":"10","author":"Jordao","year":"2008","journal-title":"Microbes Infect"},{"key":"B205","doi-asserted-by":"publisher","DOI":"10.1002\/da.20822","article-title":"Dietary intake of omega-3 fatty acids and risk of depressive symptoms in adolescents","volume":"28","author":"Oddy","year":"2011","journal-title":"Depress Anxiety"},{"key":"B206","doi-asserted-by":"publisher","first-page":"29","DOI":"10.12703\/P7-29","article-title":"Duality of lipid mediators in host response against Mycobacterium tuberculosis: good cop, bad cop","volume":"7","author":"Dietzold","year":"2015","journal-title":"F1000Prime Rep"},{"key":"B207","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20080767","article-title":"Lipid mediators in innate immunity against tuberculosis: opposing roles of PGE2 and LXA4 in the induction of macrophage death","volume":"205","author":"Chen","year":"2008","journal-title":"J Exp Med"},{"key":"B208","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-6111-1","article-title":"Dying to live: how the death modality of the infected macrophage affects immunity to tuberculosis","volume":"783","author":"Divangahi","year":"2013","journal-title":"Adv Exp Med Biol"},{"key":"B209","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2015.08.003","article-title":"Immune parameters differentiating active from latent tuberculosis infection in humans","volume":"95","author":"Lee","year":"2015","journal-title":"Tuberculosis (Edinb)"},{"key":"B210","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2017.207","article-title":"Fluoxetine induces lipid metabolism abnormalities by acting on the liver in patients and mice with depression","volume":"39","author":"Pan","year":"2018","journal-title":"Acta Pharmacol Sin"},{"key":"B211","doi-asserted-by":"publisher","DOI":"10.3109\/09637486.2015.1077790","article-title":"A review of recent evidence in human studies of n-3 and n-6 PUFA intake on cardiovascular disease, cancer, and depressive disorders: does the ratio really matter","volume":"66","author":"Marventano","year":"2015","journal-title":"Int J Food Sci Nutr"},{"key":"B212","doi-asserted-by":"publisher","DOI":"10.2217\/fmb-2018-0013","article-title":"Lipid metabolism and intracellular bacterial virulence: key to next-generation therapeutics","volume":"13","author":"Rameshwaram","year":"2018","journal-title":"Future Microbiol"},{"key":"B213","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1737230100","article-title":"Fatty acid biosynthesis in Mycobacterium tuberculosis: lateral gene transfer, adaptive evolution, and gene duplication","volume":"100","author":"Kinsella","year":"2003","journal-title":"Proc Natl Acad Sci United States America"},{"key":"B214","doi-asserted-by":"publisher","DOI":"10.3390\/nu9030298","article-title":"The relationship between fatty acids and different depression-related brain regions, and their potential role as biomarkers of response to antidepressants","volume":"9","author":"Fernandes","year":"2017","journal-title":"Nutrients"},{"key":"B215","doi-asserted-by":"publisher","first-page":"188837","DOI":"10.1016\/j.bbcan.2022.188837","article-title":"Acetyl-CoA regulates lipid metabolism and histone acetylation modification in cancer","volume":"1878","author":"He","year":"2023","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"B216","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-0135-0_41","article-title":"Tumor-induced changes in host metabolism: a possible role for free tryptophan as a marker of neoplastic disease","volume":"527","author":"Laviano","year":"2003","journal-title":"Adv Exp Med Biol"},{"key":"B217","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-020-00462-0","article-title":"Broadening horizons: the role of ferroptosis in cancer","volume":"18","author":"Chen","year":"2021","journal-title":"Nat Rev Clin Oncol"},{"key":"B218","doi-asserted-by":"publisher","DOI":"10.1111\/cas.v110.10","article-title":"Targeted exosome-encapsulated erastin induced ferroptosis in triple negative breast cancer cells","volume":"110","author":"Yu","year":"2019","journal-title":"Cancer Sci"},{"key":"B219","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S302443","article-title":"Traditional chinese formula xiaoyaosan alleviates depressive-like behavior in CUMS mice by regulating PEBP1-GPX4-mediated ferroptosis in the hippocampus","volume":"17","author":"Jiao","year":"2021","journal-title":"Neuropsychiatr Dis Treat"},{"key":"B220","doi-asserted-by":"publisher","DOI":"10.3390\/nu12113594","article-title":"Iron status is associated with mood, cognition, and functional ability in older adults: A cross-sectional study","volume":"12","author":"Portugal-Nunes","year":"2020","journal-title":"Nutrients"},{"key":"B221","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.943321","article-title":"Therapeutic application of quercetin in aging-related diseases: SIRT1 as a potential mechanism","volume":"13","author":"Cui","year":"2022","journal-title":"Front Immunol"},{"key":"B222","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27217269","article-title":"Crosstalk between depression and breast cancer via hepatic epoxide metabolism: A central comorbidity mechanism","volume":"27","author":"Ye","year":"2022","journal-title":"Molecules (Basel Switzerland)"},{"key":"B223","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.21187","article-title":"Effect of long-term supplementation with marine omega-3 fatty acids vs placebo on risk of depression or clinically relevant depressive symptoms and on change in mood scores: A randomized clinical trial","volume":"326","author":"Okereke","year":"2021","journal-title":"Jama"},{"key":"B224","doi-asserted-by":"publisher","DOI":"10.62641\/aep.v52i4.1654","article-title":"The impact of a diet rich in omega-3 fatty acids on the quality of life of patients with squamous cell lung cancer and comorbid depression: A retrospective study","volume":"52","author":"Zhang","year":"2024","journal-title":"Actas espanolas psiquiatria"},{"key":"B225","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602877","article-title":"Levels of omega-3 fatty acid in serum phospholipids and depression in patients with lung cancer","volume":"93","author":"Kobayakawa","year":"2005","journal-title":"Br J Cancer"},{"key":"B226","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601621","article-title":"Daily omega-3 fatty acid intake and depression in Japanese patients with newly diagnosed lung cancer","volume":"90","author":"Suzuki","year":"2004","journal-title":"Br J Cancer"},{"key":"B227","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.plefa.2018.11.002","article-title":"Association between blood polyunsaturated fatty acid levels and depressive symptoms in breast cancer survivors","volume":"139","author":"Okubo","year":"2018","journal-title":"Prostaglandins leukotrienes essential fatty Acids"},{"key":"B228","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.v12.19","article-title":"Effects of omega-3 supplementation on psychological symptoms in men with prostate cancer: Secondary analysis of a double-blind placebo-controlled randomized trial","volume":"12","author":"Savard","year":"2023","journal-title":"Cancer Med"},{"key":"B229","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30962-X","article-title":"Stroke","volume":"389","author":"Hankey","year":"2017","journal-title":"Lancet (London England)"},{"key":"B230","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2018.04.005","article-title":"Post stroke depression: The sequelae of cerebral stroke","volume":"90","author":"Das","year":"2018","journal-title":"Neurosci biobehavioral Rev"},{"key":"B231","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2016.01144","article-title":"Post-stroke mood and emotional disturbances: pharmacological therapy based on mechanisms","volume":"18","author":"Kim","year":"2016","journal-title":"J stroke"},{"key":"B232","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2017.11.005","article-title":"Post-stroke depression: Mechanisms and pharmacological treatment","volume":"184","author":"Villa","year":"2018","journal-title":"Pharmacol Ther"},{"key":"B233","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000294323.48661.a9","article-title":"Association of serum lipid indices with large artery atherosclerotic stroke","volume":"70","author":"Bang","year":"2008","journal-title":"Neurology"},{"key":"B234","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.546135","article-title":"Relative and cumulative effects of lipid and blood pressure control in the Stroke Prevention by Aggressive Reduction in Cholesterol Levels trial","volume":"40","author":"Amarenco","year":"2009","journal-title":"Stroke"},{"key":"B235","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-015-9732-7","article-title":"Apolipoprotein A1, B levels, and their ratio and the risk of a first stroke: a meta-analysis and case-control study","volume":"30","author":"Dong","year":"2015","journal-title":"Metab Brain Dis"},{"key":"B236","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S204791","article-title":"Serum lipid profiles and post-stroke depression in acute ischemic stroke patients","volume":"15","author":"Shen","year":"2019","journal-title":"Neuropsychiatr Dis Treat"},{"key":"B237","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.112.300133","article-title":"High-density lipoprotein function, dysfunction, and reverse cholesterol transport","volume":"32","author":"Fisher","year":"2012","journal-title":"Arteriosclerosis thrombosis Vasc Biol"},{"key":"B238","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.jad.2018.01.014","article-title":"Tryptophan-kynurenine and lipid related metabolites as blood biomarkers for first-episode drug-na\u00efve patients with major depressive disorder: An exploratory pilot case-control study","volume":"231","author":"Kuwano","year":"2018","journal-title":"J Affect Disord"},{"key":"B239","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1016\/0140-6736(92)91589-Z","article-title":"Low serum cholesterol and suicide","volume":"339","author":"Severs","year":"1992","journal-title":"Lancet (London England)"},{"key":"B240","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1016\/0140-6736(93)93165-W","article-title":"Low serum cholesterol and death due to accidents, violence, or suicide","volume":"341","author":"Epstein","year":"1993","journal-title":"Lancet (London England)"},{"key":"B241","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25488","article-title":"Can cholesterol metabolism modulation affect brain function and behavior","volume":"232","author":"Cartocci","year":"2017","journal-title":"J Cell Physiol"},{"key":"B242","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2014.10.017","article-title":"Cholesterol overload impairing cerebellar function: the promise of natural products","volume":"31","author":"El-Sayyad","year":"2015","journal-title":"Nutr (Burbank Los Angeles County Calif.)"},{"key":"B243","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.663967","article-title":"Alteration of gut microbiome and correlated lipid metabolism in post-stroke depression","volume":"11","author":"Jiang","year":"2021","journal-title":"Front Cell infection Microbiol"},{"key":"B244","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1997.tb09622.x","article-title":"Lower serum high-density lipoprotein cholesterol (HDL-C) in major depression and in depressed men with serious suicidal attempts: relationship with immune-inflammatory markers","volume":"95","author":"Maes","year":"1997","journal-title":"Acta psychiatrica Scandinavica"},{"key":"B245","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(95)00028-L","article-title":"Increased plasma concentrations of interleukin-6, soluble interleukin-6, soluble interleukin-2 and transferrin receptor in major depression","volume":"34","author":"Maes","year":"1995","journal-title":"J Affect Disord"},{"key":"B246","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvu150","article-title":"HDL in innate and adaptive immunity","volume":"103","author":"Catapano","year":"2014","journal-title":"Cardiovasc Res"},{"key":"B247","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1016\/j.molmed.2011.05.013","article-title":"Biological activities of HDL subpopulations and their relevance to cardiovascular disease","volume":"17","author":"Camont","year":"2011","journal-title":"Trends Mol Med"},{"key":"B248","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.004889","article-title":"Opposing effects of glucose on stroke and reperfusion injury: acidosis, oxidative stress, and energy metabolism","volume":"45","author":"Robbins","year":"2014","journal-title":"Stroke"},{"key":"B249","article-title":"Oxidative stress and post-stroke depression: possible therapeutic role of polyphenols","volume":"22","author":"Nabavi","year":"2015","journal-title":"Curr medicinal Chem"},{"key":"B250","doi-asserted-by":"publisher","DOI":"10.2174\/0929867321666141106122319","article-title":"Oxidative stress and post-stroke depression: possible therapeutic role of polyphenols","author":"Nabavi","year":"2014","journal-title":"Curr medicinal Chem"},{"key":"B251","doi-asserted-by":"publisher","DOI":"10.1111\/liv.2013.33.issue-7","article-title":"Associations of depression, anxiety and antidepressants with histological severity of nonalcoholic fatty liver disease","volume":"33","author":"Youssef","year":"2013","journal-title":"Liver international: Off J Int Assoc Study Liver"},{"key":"B252","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(15)00045-5","article-title":"Depression and diabetes: treatment and health-care delivery","volume":"3","author":"Petrak","year":"2015","journal-title":"Lancet Diabetes Endocrinol"},{"key":"B253","doi-asserted-by":"publisher","first-page":"85","DOI":"10.3390\/medicina45020012","article-title":"Associations of emotional state and quality of life with lipid concentration, duration of the disease, and the way of treating the disease in persons with type 2 diabetes mellitus","volume":"45","author":"Lasaite","year":"2009","journal-title":"Medicina (Kaunas Lithuania)"},{"key":"B254","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(88)90120-5","article-title":"Antidepressant-induced weight gain: a comparison study of four medications","volume":"26","author":"Fernstrom","year":"1988","journal-title":"Psychiatry Res"},{"key":"B255","doi-asserted-by":"publisher","DOI":"10.1177\/070674378803300706","article-title":"Carbohydrate craving and increased appetite associated with antidepressant therapy","volume":"33","author":"Yeragani","year":"1988","journal-title":"Can J Psychiatry Rev Can Psychiatr"},{"key":"B256","doi-asserted-by":"publisher","DOI":"10.2337\/db20-0602","article-title":"Stratification of type 2 diabetes by age of diagnosis in the UK biobank reveals subgroup-specific genetic associations and causal risk profiles","volume":"70","author":"Noordam","year":"2021","journal-title":"Diabetes"},{"key":"B257","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2023.04.114","article-title":"Effects of metabolic factors in mediating the relationship between Type 2 diabetes and depression in East Asian populations: A two-step, two-sample Mendelian randomization study","volume":"335","author":"Huang","year":"2023","journal-title":"J Affect Disord"},{"key":"B258","doi-asserted-by":"publisher","first-page":"105149","DOI":"10.1016\/j.psyneuen.2021.105149","article-title":"Serum soluble epoxide hydrolase related oxylipins and major depression in patients with type 2 diabetes","volume":"126","author":"Anita","year":"2021","journal-title":"Psychoneuroendocrinology"},{"key":"B259","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.970122","article-title":"Triglyceride glucose index is associated with cerebral small vessel disease burden and cognitive impairment in elderly patients with type 2 diabetes mellitus","volume":"13","author":"Teng","year":"2022","journal-title":"Front Endocrinol"},{"key":"B260","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1186\/s12933-022-01511-x","article-title":"Triglyceride-glucose index as a marker in cardiovascular diseases: landscape and limitations","volume":"21","author":"Tao","year":"2022","journal-title":"Cardiovasc Diabetol"},{"key":"B261","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000039258","article-title":"Association between triglyceride-glucose index and depression in patients with type 2 diabetes: A cross-sectional study from NHANES","volume":"103","author":"Ren","year":"2024","journal-title":"Medicine"},{"key":"B262","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2005.01661.x","article-title":"Fat food for a bad mood. Could we treat and prevent depression in Type 2 diabetes by means of omega-3 polyunsaturated fatty acids? A review of the evidence","volume":"22","author":"Pouwer","year":"2005","journal-title":"Diabetic medicine: A J Br Diabetic Assoc"},{"key":"B263","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.pnpbp.2017.04.027","article-title":"Shared metabolic and immune-inflammatory, oxidative and nitrosative stress pathways in the metabolic syndrome and mood disorders","volume":"78","author":"de Melo","year":"2017","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"B264","doi-asserted-by":"publisher","DOI":"10.1080\/10401230701653377","article-title":"Should depressive syndromes be reclassified as \u201cMetabolic syndrome type II\u201d","volume":"19","author":"McIntyre","year":"2007","journal-title":"Ann Clin psychiatry: Off J Am Acad Clin Psychiatrists"},{"key":"B265","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.jad.2014.02.018","article-title":"Lowered plasma paraoxonase (PON)1 activity is a trait marker of major depression and PON1 Q192R gene polymorphism-smoking interactions differentially predict the odds of major depression and bipolar disorder","volume":"159","author":"Bortolasci","year":"2014","journal-title":"J Affect Disord"},{"key":"B266","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.v34.3","article-title":"A case-control study: The association of serum paraoxonase 1 activity and concentration with the development of type 2 diabetes mellitus","volume":"34","author":"Crow","year":"2018","journal-title":"Diabetes\/metabolism Res Rev"},{"key":"B267","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.2018.22.issue-9","article-title":"The association between paraoxonase 1 activity and the susceptibilities of diabetes mellitus, diabetic macroangiopathy and diabetic microangiopathy","volume":"22","author":"Wu","year":"2018","journal-title":"J Cell Mol Med"},{"key":"B268","doi-asserted-by":"publisher","first-page":"1752940","DOI":"10.1155\/2018\/1752940","article-title":"Distribution of paraoxonase-1 (PON-1) and lipoprotein phospholipase A2 (Lp-PLA2) across lipoprotein subclasses in subjects with type 2 diabetes","volume":"2018","author":"Passaro","year":"2018","journal-title":"Oxid Med Cell Longevity"},{"key":"B269","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2018.03.055","article-title":"Abnormalities in the relationship of paraoxonase 1 with HDL and apolipoprotein A1 and their possible connection to HDL dysfunctionality in type 2 diabetes","volume":"140","author":"Viktorinova","year":"2018","journal-title":"Diabetes Res Clin Pract"},{"key":"B270","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1002\/hep.28431","article-title":"Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes","volume":"64","author":"Younossi","year":"2016","journal-title":"Hepatol (Baltimore Md.)"},{"key":"B271","doi-asserted-by":"publisher","first-page":"e14087","DOI":"10.1111\/eci.14087","article-title":"Depression in nonalcoholic fatty liver disease and all-cause\/cause-specific mortality","volume":"54","author":"Kim","year":"2024","journal-title":"Eur J Clin Invest"},{"key":"B272","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.jad.2021.12.128","article-title":"Association between nonalcoholic fatty liver disease and depression: A systematic review and meta-analysis of observational studies","volume":"301","author":"Gu","year":"2022","journal-title":"J Affect Disord"},{"key":"B273","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32279-7","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"392","year":"2018","journal-title":"Lancet (London England)"},{"key":"B274","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9111697","article-title":"Non-alcoholic fatty liver disease (NAFLD) and potential links to depression, anxiety, and chronic stress","volume":"9","author":"Shea","year":"2021","journal-title":"Biomedicines"},{"key":"B275","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajg.2019.05.004","article-title":"Egyptian liver library: An indexed database for liver disease evidence in Egypt","volume":"20","author":"Alboraie","year":"2019","journal-title":"Arab J gastroenterol"},{"key":"B276","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2020.09.073","article-title":"Association between depression and nonalcoholic fatty liver disease: Contributions of insulin resistance and inflammation","volume":"278","author":"Lee","year":"2021","journal-title":"J Affect Disord"},{"key":"B277","doi-asserted-by":"publisher","DOI":"10.1097\/01.psy.0000221276.17823.df","article-title":"Depression, anxiety, and nonalcoholic steatohepatitis","volume":"68","author":"Elwing","year":"2006","journal-title":"Psychosomatic Med"},{"key":"B278","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0261555","article-title":"Depressive symptoms in non-alcoholic fatty liver disease are identified by perturbed lipid and lipoprotein metabolism","volume":"17","author":"Radford-Smith","year":"2022","journal-title":"PloS One"},{"key":"B279","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.585618","article-title":"Association between anxiety and depression and nonalcoholic fatty liver disease","volume":"7","author":"Choi","year":"2020","journal-title":"Front Med"},{"key":"B280","doi-asserted-by":"publisher","DOI":"10.21873\/invivo.13618","article-title":"Depression exacerbates hepatic steatosis in C57BL\/6J mice by activating the hypothalamic-pituitary-adrenal axis","volume":"38","author":"Su","year":"2024","journal-title":"In Vivo (Athens Greece)"},{"key":"B281","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.07.034","article-title":"FXR agonists in NASH treatment","volume":"79","author":"Adorini","year":"2023","journal-title":"J hepatol"},{"key":"B282","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.12373","article-title":"Identification of functional farnesoid X receptors in brain neurons","volume":"590","author":"Huang","year":"2016","journal-title":"FEBS Lett"},{"key":"B283","doi-asserted-by":"publisher","DOI":"10.1002\/glia.v58:15","article-title":"The bile acid receptor TGR5 (Gpbar-1) acts as a neurosteroid receptor in brain","volume":"58","author":"Keitel","year":"2010","journal-title":"Glia"},{"key":"B284","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2022.08.008","article-title":"Partial MCT1 invalidation protects against diet-induced non-alcoholic fatty liver disease and the associated brain dysfunction","volume":"78","author":"Hadjihambi","year":"2023","journal-title":"J hepatol"},{"key":"B285","doi-asserted-by":"publisher","first-page":"122898","DOI":"10.1016\/j.jchromb.2021.122898","article-title":"Tandem mass tag-based quantitative proteomic analysis of the liver reveals potential protein targets of Xiaochaihutang in CUMS model of depression","volume":"1181","author":"Xu","year":"2021","journal-title":"J chromatogr B Analytical Technol Biomed Life Sci"},{"key":"B286","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2022.2071109","article-title":"The effect of a fruit-rich diet on liver biomarkers, insulin resistance, and lipid profile in patients with non-alcoholic fatty liver disease: a randomized clinical trial","volume":"57","author":"Alami","year":"2022","journal-title":"Scandinavian J gastroenterol"},{"key":"B287","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2015.11.006","article-title":"The evidence for saturated fat and for sugar related to coronary heart disease","volume":"58","author":"DiNicolantonio","year":"2016","journal-title":"Prog Cardiovasc Dis"},{"key":"B288","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2016.02.045","article-title":"Insulin receptor sensitizer, dicholine succinate, prevents both Toll-like receptor 4 (TLR4) upregulation and affective changes induced by a high-cholesterol diet in mice","volume":"196","author":"Strekalova","year":"2016","journal-title":"J Affect Disord"},{"key":"B289","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2015.02.015","article-title":"Tlr4 upregulation in the brain accompanies depression- and anxiety-like behaviors induced by a high-cholesterol diet","volume":"48","author":"Strekalova","year":"2015","journal-title":"Brain behavior Immun"},{"key":"B290","doi-asserted-by":"publisher","first-page":"155292","DOI":"10.1016\/j.metabol.2022.155292","article-title":"Imipramine activates FAM3A-FOXA2-CPT2 pathway to ameliorate hepatic steatosis","volume":"136","author":"Liu","year":"2022","journal-title":"Metabolism: Clin Exp"},{"key":"B291","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.taap.2015.03.006","article-title":"Antenatal exposure to the selective serotonin reuptake inhibitor fluoxetine leads to postnatal metabolic and endocrine changes associated with type 2 diabetes in Wistar rats","volume":"285","author":"De Long","year":"2015","journal-title":"Toxicol Appl Pharmacol"},{"key":"B292","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0b013e32835a4206","article-title":"Effects of antidepressants on glucose metabolism and diabetes mellitus type 2 in adults","volume":"26","author":"Deuschle","year":"2013","journal-title":"Curr Opin Psychiatry"},{"key":"B293","doi-asserted-by":"publisher","DOI":"10.1111\/cns.2012.18.issue-12","article-title":"Fluoxetine induces hepatic lipid accumulation via both promotion of the SREBP1c-related lipogenesis and reduction of lipolysis in primary mouse hepatocytes","volume":"18","author":"Feng","year":"2012","journal-title":"CNS Neurosci Ther"},{"key":"B294","doi-asserted-by":"publisher","DOI":"10.1002\/jat.v41.8","article-title":"Downregulation of glucose-6-phosphatase expression contributes to fluoxetine-induced hepatic steatosis","volume":"41","author":"Lu","year":"2021","journal-title":"J Appl toxicol: JAT"},{"key":"B295","doi-asserted-by":"publisher","DOI":"10.1159\/000350094","article-title":"Molecular mechanisms of depression: perspectives on new treatment strategies","volume":"31","author":"Lang","year":"2013","journal-title":"Cell Physiol biochem: Int J Exp Cell physiol biochem Pharmacol"},{"key":"B296","doi-asserted-by":"publisher","DOI":"10.1002\/jat.v42.6","article-title":"Fluoxetine-induced hepatic lipid accumulation is mediated by prostaglandin endoperoxide synthase 1 and is linked to elevated 15-deoxy-\u0394(12,14) PGJ(2)","volume":"42","author":"Ayyash","year":"2022","journal-title":"J Appl toxicol: JAT"},{"key":"B297","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30173-8","article-title":"Rheumatoid arthritis","volume":"388","author":"Smolen","year":"2016","journal-title":"Lancet (London England)"},{"key":"B298","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket169","article-title":"The prevalence of depression in rheumatoid arthritis: a systematic review and meta-analysis","volume":"52","author":"Matcham","year":"2013","journal-title":"Rheumatol (Oxford England)"},{"key":"B299","doi-asserted-by":"publisher","first-page":"105200","DOI":"10.1016\/j.jbspin.2021.105200","article-title":"Rheumatoid arthritis and depression","volume":"88","author":"Fakra","year":"2021","journal-title":"Joint Bone Spine"},{"key":"B300","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000597","article-title":"Depression and the risk of rheumatoid arthritis","volume":"31","author":"Vallerand","year":"2019","journal-title":"Curr Opin Rheumatol"},{"key":"B301","doi-asserted-by":"publisher","DOI":"10.1007\/s00393-015-1661-7","article-title":"Disease activity, obesity, functional disability, and depression in patients with rheumatoid arthritis: Impact on lipid status, glycoregulation, and risk for coronary heart disease","volume":"75","author":"Ostojic","year":"2016","journal-title":"Z fur Rheumatologie"},{"key":"B302","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1190607","article-title":"Lipid metabolism and rheumatoid arthritis","volume":"14","author":"Lei","year":"2023","journal-title":"Front Immunol"},{"key":"B303","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2009.106","article-title":"Stress and disorders of the stress system","volume":"5","author":"Chrousos","year":"2009","journal-title":"Nat Rev Endocrinol"},{"key":"B304","doi-asserted-by":"publisher","first-page":"167395","DOI":"10.1016\/j.scitotenv.2023.167395","article-title":"Exposure to low-intensity noise exacerbates nonalcoholic fatty liver disease by activating hypothalamus pituitary adrenal axis","volume":"906","author":"Luo","year":"2024","journal-title":"Sci Total Environ"},{"key":"B305","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1152\/physrev.00041.2006","article-title":"Physiology and neurobiology of stress and adaptation: central role of the brain","volume":"87","author":"McEwen","year":"2007","journal-title":"Physiol Rev"},{"key":"B306","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4050","article-title":"Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants","volume":"22","author":"Duman","year":"2016","journal-title":"Nat Med"},{"key":"B307","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2009.02.009","article-title":"Salivary cortisol, serum lipids, and adiposity in patients with depressive and anxiety disorders","volume":"58","author":"Veen","year":"2009","journal-title":"Metabolism"},{"key":"B308","doi-asserted-by":"publisher","DOI":"10.1042\/cs0960513","article-title":"Glucocorticoids and insulin resistance: old hormones, new targets","volume":"96","author":"Andrews","year":"1999","journal-title":"Clin Sci (Lond)"},{"key":"B309","doi-asserted-by":"publisher","DOI":"10.1210\/endo-129-3-1363","article-title":"Modulatory effects of unsaturated fatty acids on the binding of glucocorticoids to rat liver glucocorticoid receptors","volume":"129","author":"Vallette","year":"1991","journal-title":"Endocrinology"},{"key":"B310","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145704004249","article-title":"Ethyl-eicosapentaenoate and dexamethasone resistance in therapy-refractory depression","volume":"7","author":"Murck","year":"2004","journal-title":"Int J Neuropsychopharmacol"},{"key":"B311","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2233","article-title":"A neuroscientist\u2019s guide to lipidomics","volume":"8","author":"Piomelli","year":"2007","journal-title":"Nat Rev Neurosci"},{"key":"B312","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neuroscience.2014.04.042","article-title":"Alterations in phospholipidomic profile in the brain of mouse model of depression induced by chronic unpredictable stress","volume":"273","author":"Faria","year":"2014","journal-title":"Neuroscience"},{"key":"B313","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1038\/sj.mp.4001888","article-title":"n-3 polyunsaturated fatty acid deprivation in rats decreases frontal cortex BDNF via a p38 MAPK-dependent mechanism","volume":"12","author":"Rao","year":"2007","journal-title":"Mol Psychiatry"},{"key":"B314","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-012-3665-2","article-title":"Statistical methodological issues in handling of fatty acid data: percentage or concentration, imputation and indices","volume":"47","author":"Mocking","year":"2012","journal-title":"Lipids"},{"key":"B315","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.12.003","article-title":"Mifepristone alters amyloid precursor protein processing to preclude amyloid beta and also reduces tau pathology","volume":"74","author":"Baglietto-Vargas","year":"2013","journal-title":"Biol Psychiatry"},{"key":"B316","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.jep.2011.08.030","article-title":"Effects of a Chinese traditional formula Kai Xin San (KXS) on chronic fatigue syndrome mice induced by forced wheel running","volume":"139","author":"Cao","year":"2012","journal-title":"J Ethnopharmacol"},{"key":"B317","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-018-0582-9","article-title":"Proteomic analysis of the antidepressant effects of shen-zhi-ling in depressed patients: identification of proteins associated with platelet activation and lipid metabolism","volume":"38","author":"Chen","year":"2018","journal-title":"Cell Mol Neurobiol"},{"key":"B318","doi-asserted-by":"publisher","first-page":"112615","DOI":"10.1016\/j.jep.2020.112615","article-title":"Anti-depressive effects of Kai-Xin-San on lipid metabolism in depressed patients and CUMS rats using metabolomic analysis","volume":"252","author":"Zhou","year":"2020","journal-title":"J Ethnopharmacol"},{"key":"B319","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.plipres.2015.12.003","article-title":"The role of omega-3 polyunsaturated fatty acids eicosapentaenoic and docosahexaenoic acids in the treatment of major depression and Alzheimer\u2019s disease: Acting separately or synergistically","volume":"62","author":"Song","year":"2016","journal-title":"Prog Lipid Res"},{"key":"B320","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0067617","article-title":"Low omega-3 index in pregnancy is a possible biological risk factor for postpartum depression","volume":"8","author":"Markhus","year":"2013","journal-title":"PloS One"},{"key":"B321","doi-asserted-by":"publisher","DOI":"10.1126\/science.1110647","article-title":"Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo","volume":"308","author":"Nimmerjahn","year":"2005","journal-title":"Science"},{"key":"B322","doi-asserted-by":"publisher","first-page":"697","DOI":"10.3233\/JAD-130131","article-title":"Omega-3 fatty acids enhance phagocytosis of Alzheimer\u2019s disease-related amyloid-\u03b242 by human microglia and decrease inflammatory markers","volume":"35","author":"Hjorth","year":"2013","journal-title":"J Alzheimers Dis"},{"key":"B323","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2022.1040410","article-title":"Lifestyle-related risk factors correlated with mental health problems: A longitudinal observational study among 686 male college students in Chongqing, China","volume":"10","author":"Yang","year":"2022","journal-title":"Front Public Health"},{"key":"B324","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.1c04647","article-title":"Association between acrylamide hemoglobin adduct levels and depressive symptoms in US adults: NHANES 2013-2016","volume":"69","author":"Li","year":"2021","journal-title":"J Agric Food Chem"},{"key":"B325","doi-asserted-by":"publisher","first-page":"113949","DOI":"10.1016\/j.expneurol.2021.113949","article-title":"High fat diet-induced obesity leads to depressive and anxiety-like behaviors in mice via AMPK\/mTOR-mediated autophagy","volume":"348","author":"Li","year":"2022","journal-title":"Exp Neurol"},{"key":"B326","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1111\/pcn.13370","article-title":"Gut-microbiota-brain axis by bile acids in depression","volume":"76","author":"Hashimoto","year":"2022","journal-title":"Psychiatry Clin Neurosci"},{"key":"B327","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24010578","article-title":"Selected biomarkers of depression: what are the effects of cytokines and inflammation","volume":"24","author":"Harsanyi","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B328","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2023.04.003","article-title":"Morning salivary dehydroepiandrosterone (DHEA) qualifies as the only neuroendocrine biomarker separating depressed patients with and without prior history of depression: An HPA axis challenge study","volume":"161","author":"Agorastos","year":"2023","journal-title":"J Psychiatr Res"},{"key":"B329","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-024-01287-0","article-title":"Advancements in diagnosis and treatment of cardiac sarcomas: a comprehensive review","volume":"26","author":"Wang","year":"2025","journal-title":"Curr Treat Options Oncol"}],"container-title":["Frontiers in Psychiatry"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpsyt.2025.1589663\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T17:29:56Z","timestamp":1748539796000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpsyt.2025.1589663\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,29]]},"references-count":329,"alternative-id":["10.3389\/fpsyt.2025.1589663"],"URL":"https:\/\/doi.org\/10.3389\/fpsyt.2025.1589663","relation":{},"ISSN":["1664-0640"],"issn-type":[{"value":"1664-0640","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,29]]},"article-number":"1589663"}}