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Psychiatry"],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Assess the clinical efficacy of paroxetine and sulpiride IV drip in treating depression and its impact on sleep and quality of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective analysis of 80 depression patients, divided into a study group treated with paroxetine and sulpiride IV drip, and a control group treated with paroxetine alone, over 8 weeks. HAMD and SF-36 assessed depression and quality of life; TESS evaluated adverse reactions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>HAMD scores decreased in both groups, with the study group showing better depression status at 1, 2, and 4 weeks (P&amp;lt;0.05) and higher effective rates (P&amp;lt;0.05). The study group had faster symptom relief. SF-36 scores in role physical, general health, vitality, and role emotional were higher in the study group (P&amp;lt;0.05). TESS scores showed no significant difference between groups (P&amp;gt;0.05), with mild adverse reactions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Paroxetine with sulpiride IV drip offers rapid relief and high safety in depression treatment, improving sleep and quality of life.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpsyt.2025.1600675","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T05:45:37Z","timestamp":1758087937000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of paroxetine combined with sulpiride on sleep status and quality of life in patients with depressive 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