{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:27:12Z","timestamp":1753892832762,"version":"3.41.2"},"reference-count":80,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Mentalization or Theory of Mind (ToM) is crucial for interpreting social situations and understanding others\u2019 beliefs and intentions. Irony comprehension, which involves constructing a coherent narrative from contradictory information, is linked to ToM. This study examines first-degree relatives of individuals diagnosed with bipolar I disorder to determine if irony comprehension and its neural correlates can serve as endophenotypic markers for bipolar disorder.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study recruited 16 biological first-degree relatives of individuals diagnosed with bipolar I disorder (Relative Group, RG) and 16 healthy controls (Control Group, CG). Participants underwent an irony comprehension task under three conditions: irony (I), irony with linguistic assistance (IH), and control (C). Functional magnetic resonance imaging (fMRI) was employed to elucidate brain activation patterns during task execution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Behavioral analysis revealed no significant differences in task performance between RG and CG across all conditions. However, fMRI results demonstrated distinct neural activation patterns between groups during the statement phase of the tasks. The RG exhibited reduced activation in the temporoparietal junction, posterior cingulate cortex, thalamus, and cerebellum compared to CG in the I&amp;gt;IH contrast. Conversely, RG individuals exhibited enhanced activation in these regions during the IH&amp;gt;I and IH&amp;gt;C contrasts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>First-degree relatives of bipolar patients showed altered brain activity patterns during irony comprehension tasks, despite comparable behavioral performance. The observed neural patterns could indicate alternative cognitive strategies or latent vulnerability markers, underscoring the need for further multimodal investigation. Altered neural activation during irony processing may serve as an endophenotypic marker for bipolar disorder. Future research should explore these findings in larger cohorts and assess additional cognitive factors.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpsyt.2025.1606988","type":"journal-article","created":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T05:22:45Z","timestamp":1750396965000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Irony comprehension in first-degree relatives of patients with bipolar affective disorder \u2013 a preliminary fMRI study"],"prefix":"10.3389","volume":"16","author":[{"given":"Andr\u00e1s S\u00e1ndor","family":"Hajnal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eszter","family":"Varga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tam\u00e1s","family":"T\u00e9nyi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Borb\u00e1la","family":"Peth\u0151","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"No\u00e9mi","family":"Albert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rton","family":"Herold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rton \u00c1ron","family":"Kov\u00e1cs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T\u00edmea","family":"Csulak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00f3ra","family":"Hebling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00f3bert","family":"Herold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,6,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2017.10.030","article-title":"The multifaceted role of the ventromedial prefrontal cortex in emotion, decision making, social cognition, and psychopathology","volume":"83","author":"Hiser","year":"2018","journal-title":"Biol Psychiatry"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23675","article-title":"Specifying the brain anatomy underlying temporo-parietal junction activations for theory of mind: A review using probabilistic atlases from different imaging modalities","volume":"38","author":"Schurz","year":"2017","journal-title":"Hum Brain Mapp"},{"key":"B3","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.neubiorev.2014.01.009","article-title":"Fractionating theory of mind: a meta-analysis of functional brain imaging studies","volume":"42","author":"Schurz","year":"2014","journal-title":"Neurosci Biobehav Rev"},{"key":"B4","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/B978-0-12-823493-8.00017-1","article-title":"Amygdala connectivity and implications for social cognition and disorders","volume":"187","author":"Meisner","year":"2022","journal-title":"Handb Clin Neurol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2011.07.012","article-title":"Neuroanatomical and neurochemical bases of theory of mind","volume":"49","author":"Abu-Akel","year":"2011","journal-title":"Neuropsychologia"},{"key":"B6","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1523\/JNEUROSCI.0479-18.2018","article-title":"The cognitive thalamus as a gateway to mental representations","volume":"39","author":"Wolff","year":"2019","journal-title":"J Neurosci"},{"key":"B7","doi-asserted-by":"publisher","first-page":"e67","DOI":"10.1017\/S003329172500039X","article-title":"Contributions of the posterior cerebellum to mentalizing and social functioning: A transdiagnostic investigation","volume":"55","author":"Moe","year":"2025","journal-title":"psychol medicine"},{"key":"B8","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1093\/cercor\/bhab260","article-title":"The social cerebellum: A large-scale investigation of functional and structural specificity and connectivity","volume":"32","author":"Metoki","year":"2022","journal-title":"Cereb cortex"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1111\/gbb.12066","article-title":"Theory of mind and the social brain: implications for understanding the genetic basis of schizophrenia","volume":"13","author":"Martin","year":"2014","journal-title":"Genes Brain Behavior"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2017.02309","article-title":"Altered Neural Activity during Irony Comprehension in Unaffected First-Degree Relatives of Schizophrenia Patients-An fMRI Study","volume":"8","author":"Herold","year":"2018","journal-title":"Front Psychol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579420000577","article-title":"Social endophenotypes in autism spectrum disorder: A scoping review","volume":"33","author":"Tiede","year":"2021","journal-title":"Dev Psychopathology"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291721004165","article-title":"Emotional cognition subgroups in unaffected first-degree relatives of patients with mood disorders","volume":"53","author":"Kj\u00e6rstad","year":"2023","journal-title":"psychol Medicine"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.4.636","article-title":"The endophenotype concept in psychiatry: etymology and strategic intentions","volume":"106","author":"Gottesman","year":"2003","journal-title":"Am J Psychiatry"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1177\/0004867420924109","article-title":"Impaired social cognition in bipolar disorder: A meta-analysis of Theory of Mind in euthymic patients","volume":"54","author":"de Siqueira Rotenberg","year":"2020","journal-title":"Aust New Zeal J Psychiatry"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2016.09.063","article-title":"Neurocognition and psychosocial functioning in adolescents with bipolar disorder","volume":"207","author":"Best","year":"2017","journal-title":"J Affect Disord"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2017.12.094","article-title":"Psychosocial functioning in patients with psychotic and non-psychotic bipolar I disorder. A comparative study with individuals with schizophrenia","volume":"229","author":"Jim\u00e9nez-L\u00f3pez","year":"2018","journal-title":"J Affec Disord"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1017\/S003329171700143X","article-title":"Neurocognitive subtypes in patients with bipolar disorder and their unaffected siblings","volume":"47","author":"Russo","year":"2017","journal-title":"Psychol Med"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2017.09.039","article-title":"What your eyes tell me: Theory of mind in bipolar disorder","volume":"262","author":"Espin\u00f3s","year":"2018","journal-title":"Psychiatry Res"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2024.01.022","article-title":"Patients with chronic bipolar disorder show impairments in interpreting literary fiction - A preliminary explorative study with the short story task","volume":"171","author":"Herold","year":"2024","journal-title":"J Psychiatr Res"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2007.08.009","article-title":"Theory of mind deficit in bipolar disorder: is it related to a previous history of psychotic symptoms","volume":"161","author":"Lahera","year":"2008","journal-title":"Psychiatry Res"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2013.06.051","article-title":"In your eyes: does theory of mind predict impaired life functioning in bipolar disorder","volume":"151","author":"Purcell","year":"2013","journal-title":"J Affect Disord"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2013.00661","article-title":"Neuropsychology, social cognition and global functioning among bipolar, schizophrenic patients and healthy controls: preliminary data","volume":"7","author":"Caletti","year":"2013","journal-title":"Front Hum Neurosci"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2011.04.033","article-title":"Theory of mind and facial emotion recognition in euthymic bipolar I and bipolar II disorders","volume":"189","author":"Martino","year":"2011","journal-title":"Psychiatry Res"},{"key":"B24","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.rpsm.2012.07.004","article-title":"Theory of mind and functionality in bipolar patients with symptomatic remission","volume":"6","author":"Barrera","year":"2013","journal-title":"Rev Psiquiatria y Salud Mental"},{"key":"B25","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1176\/jnp.2009.21.1.59","article-title":"Neuropsychological evidence of impaired cognitive empathy in euthymic bipolar disorder","volume":"21","author":"Shamay-Tsoory","year":"2009","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2009.08.017","article-title":"Theory of mind impairments in euthymic bipolar patients","volume":"123","author":"Montag","year":"2010","journal-title":"J Affect Disord"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2017.11.003","article-title":"Theory of mind impairment and its clinical correlates in patients with schizophrenia, major depressive disorder and bipolar disorder","volume":"197","author":"Wang","year":"2018","journal-title":"Schizophr Res"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2005.00570.x","article-title":"Evidence for theory of mind deficits in euthymic patients with bipolar disorder","volume":"112","author":"Bora","year":"2005","journal-title":"Acta Psychiatrica Scandinavica"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2013.12.042","article-title":"Theory of mind and hypomanic traits in general population","volume":"215","author":"Terrien","year":"2014","journal-title":"Psychiatry Res"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2010.02.004","article-title":"Impaired theory of mind performance in patients with recurrent bipolar disorder: Moderating effect of cognitive load","volume":"177","author":"Mckinnon","year":"2010","journal-title":"Psychiatry Res"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/s0165-0327(02)00008-3","article-title":"Theory of mind deficits in bipolar affective disorder","volume":"73","author":"Kerr","year":"2003","journal-title":"J Affect Disord"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2010.00854.x","article-title":"Theory of mind and neurocognitive functioning in patients with bipolar disorder","volume":"12","author":"Wolf","year":"2010","journal-title":"Bipolar Disord"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2011.01808.x","article-title":"Social cognition in euthymic bipolar disorder: systematic review and meta-analytic approach","volume":"125","author":"Samame","year":"2012","journal-title":"Acta Psychiatr Scand"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291715001993","article-title":"Meta-analysis of Theory of Mind (ToM) impairment in bipolar disorder","volume":"46","author":"Bora","year":"2016","journal-title":"Psychol Med"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2012.12040490","article-title":"Social and nonsocial cognition in bipolar disorder and schizophrenia: relative levels of impairment","volume":"170","author":"Lee","year":"2013","journal-title":"Am J Psychiatry"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2013.09.010","article-title":"Differential impairment of social cognition factors in bipolar disorder with and without psychotic features and schizophrenia","volume":"47","author":"Thaler","year":"2013","journal-title":"J Psychiatr Res"},{"key":"B37","first-page":"17","article-title":"The relationship of theory of mind with symptoms and cognitive impairment in bipolar disorder: a prospective study","volume":"26","author":"Ioannidi","year":"2015","journal-title":"Psychiatriki"},{"key":"B38","first-page":"8","article-title":"The relationship of verbal working memory and theory of mind in first degree relatives of patients with schizophrenia and bipolar disorder","volume":"27","author":"Y\u00fccel","year":"2016","journal-title":"Turk Psikiyatri Derg"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2006.04.018","article-title":"Deficit in theory of mind is a risk for relapse of major depression","volume":"95","author":"Inoue","year":"2006","journal-title":"J Affect Disord"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2014.05.041","article-title":"Theory of mind in first degree relatives of individuals with bipolar disorder","volume":"219","author":"Reynolds","year":"2014","journal-title":"Psychiatry Res"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1097\/NMD.0000000000000595","article-title":"Theory of mind in euthymic bipolar patients and first-degree relatives","volume":"205","author":"Santos","year":"2017","journal-title":"J Nerv Ment Dis"},{"key":"B42","article-title":"Szoci\u00e1lis kognit\u00edv funkci\u00f3k vizsg\u00e1lata bipol\u00e1ris betegek els\u0151fok\u00fa hozz\u00e1tartoz\u00f3i k\u00f6r\u00e9ben","volume":"31","author":"Berecz","year":"2016","journal-title":"Psychiatria Hungarica"},{"key":"B43","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.euroneuro.2017.02.009","article-title":"Social cognition in first-degree relatives of patients with bipolar disorder: A meta-analysis","volume":"27","author":"Bora","year":"2017","journal-title":"Eur Neuropsychopharmacol"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2015.10.026","article-title":"Theory-of-mind understanding and theory-of-mind use in unaffected first-degree relatives of schizophrenia and bipolar disorder","volume":"230","author":"Wang","year":"2015","journal-title":"Psychiatry Res"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291715002147","article-title":"Neuropsychological and social cognitive function in young people at genetic risk of bipolar disorder","volume":"46","author":"Mccormack","year":"2016","journal-title":"Psychol Med"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12352","article-title":"Alterations in neural Theory of Mind processing in euthymic patients with bipolar disorder and unaffected relatives","volume":"17","author":"Willert","year":"2015","journal-title":"Bipolar Disord"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2012.08.016","article-title":"Socio-emotional processing and functioning of youth at high risk for bipolar disorder","volume":"148","author":"Whitney","year":"2013","journal-title":"J Affect Disord"},{"key":"B48","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1007\/s00787-021-01722-9","article-title":"Heterogeneity of social cognitive and language functions in children at familial high-risk of severe mental illness; The Danish High Risk and Resilience Study VIA 7","volume":"31","author":"Christiani","year":"2022","journal-title":"Eur Child Adolesc Psychiatry"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2015.04.010","article-title":"Brain activation during self- and other-reflection in bipolar disorder with a history of psychosis: Comparison to schizophrenia","volume":"8","author":"Zhang","year":"2015","journal-title":"NeuroImage Clin"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2021.111340","article-title":"Aberrant activation of the mentalizing brain system during eye gaze discrimination in bipolar disorder","volume":"315","author":"Tso","year":"2021","journal-title":"Psychiatry Res Neuroimaging"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2021.102836","article-title":"A fundamental distinction in early neural processing of implicit social interpretation in schizophrenia and bipolar disorder","volume":"32","author":"Madeira","year":"2021","journal-title":"NeuroImage Clin"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2022.971244","article-title":"Theory of mind profile and cerebellar alterations in remitted bipolar disorder 1 and 2: a comparison study","volume":"16","author":"Olivito","year":"2022","journal-title":"Front Behav Neurosci"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2016.08.018","article-title":"Functional dysconnection of the inferior frontal gyrus in young people with bipolar disorder or at genetic high risk","volume":"81","author":"Roberts","year":"2017","journal-title":"Biol Psychiatry"},{"key":"B54","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/1468-0017.00186","article-title":"Pragmatics, modularity and mind-reading","volume":"17","author":"Sperber","year":"2002","journal-title":"Mind Lang"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/685613","article-title":"Mental state inferences abilities contribution to verbal irony comprehension in older adults with mild cognitive impairment","volume":"2015","author":"Gaudreau","year":"2015","journal-title":"Behav Neurol"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1002\/aur.3051","article-title":"Comprehension of irony in autistic children: The role of theory of mind and executive function","volume":"17","author":"Song","year":"2024","journal-title":"Autism Res"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.10.030","article-title":"Neural substrates of irony comprehension: A functional MRI study","volume":"1308","author":"Shibata","year":"2010","journal-title":"Brain Res"},{"key":"B58","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.neuroimage.2012.06.046","article-title":"Neural evidence that utterance-processing entails mentalizing: the case of irony","volume":"63","author":"Spotorno","year":"2012","journal-title":"Neuroimage"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandl.2013.05.017","article-title":"Irony comprehension and context processing in schizophrenia during remission-A functional MRI study","volume":"126","author":"Varga","year":"2013","journal-title":"Brain Lang"},{"volume-title":"Structured clinical interview for DSM-IV-TR axis I disorders, clinical trials version (SCID-CT)","year":"2007","author":"First","key":"B60"},{"key":"B61","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/0028-3932(71)90067-4","article-title":"The assessment and analysis of handedness: the Edinburgh inventory","volume":"9","author":"Oldfield","year":"1971","journal-title":"Neuropsychologia"},{"volume-title":"SPSS: statistical package for the social sciences","year":"1975","author":"Nie","key":"B62"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/s1361-8415(01)00036-6","article-title":"A global optimisation method for robust affine registration of brain images","volume":"5","author":"Jenkinson","year":"2001","journal-title":"Med Image Anal"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.10062","article-title":"Fast robust automated brain extraction","volume":"17","author":"Smith","year":"2002","journal-title":"Hum Brain Mapp"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0931","article-title":"Temporal autocorrelation in univariate linear modelling of fMRI data","volume":"14","author":"Woolrich","year":"2001","journal-title":"Neuroimage"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1016\/s1053-8119(02)91132-8","article-title":"Improved optimization for the robust and accurate linear registration and motion correction of brain images","volume":"17","author":"Jenkinson","year":"2002","journal-title":"Neuroimage"},{"volume-title":"Non-linear optimisation. FMRIB technical report TR07JA1","year":"2007","author":"Andersson","key":"B67"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(03)00435-X","article-title":"General multilevel linear modeling for group analysis in FMRI","volume":"20","author":"Beckmann","year":"2003","journal-title":"Neuroimage"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2003.12.023","article-title":"Multilevel linear modelling for FMRI group analysis using Bayesian inference","volume":"21","author":"Woolrich","year":"2004","journal-title":"Neuroimage"},{"key":"B70","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.neuroimage.2008.02.042","article-title":"Robust group analysis using outlier inference","volume":"41","author":"Woolrich","year":"2008","journal-title":"Neuroimage"},{"key":"B71","doi-asserted-by":"crossref","DOI":"10.1093\/acprof:oso\/9780192630711.003.0014","article-title":"Statistical analysis of activation images","volume-title":"Functional magnetic resonance imaging: an introduction to methods","author":"Worsley","year":"2001"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.06.022","article-title":"Where in the brain is nonliteral language? A coordinate-based meta-analysis of functional magnetic resonance imaging studies","volume":"63","author":"Rapp","year":"2012","journal-title":"Neuroimage"},{"key":"B73","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.cortex.2017.06.010","article-title":"Neural correlates underlying the comprehension of deceitful and ironic communicative intentions","volume":"94","author":"Bosco","year":"2017","journal-title":"Cortex"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2016.03.020","article-title":"Understanding the minds of others: A neuroimaging meta-analysis","volume":"65","author":"Molenberghs","year":"2016","journal-title":"Neurosci Biobehav Rev"},{"key":"B75","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1093\/brain\/awt162","article-title":"The role of the posterior cingulate cortex in cognition and disease","volume":"137","author":"Leech","year":"2014","journal-title":"Brain"},{"key":"B76","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.cortex.2017.12.014","article-title":"The neural correlates of visual imagery: A co-ordinate-based meta-analysis","volume":"105","author":"Winlove","year":"2018","journal-title":"Cortex"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0246908","article-title":"Social cognition in first-degree relatives of bipolar disorder: Theory of Mind and nonverbal sensitivity","volume":"16","author":"Espin\u00f3s","year":"2021","journal-title":"PloS One"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2007.09.002","article-title":"Executive and verbal working memory dysfunction in first-degree relatives of patients with bipolar disorder","volume":"161","author":"Bora","year":"2008","journal-title":"Psychiatry Res"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajp.2020.102246","article-title":"Cognitive performance and psychosocial functioning in unaffected siblings of bipolar disorder patients in comparison with healthy controls","volume":"54","author":"Chandrasekaran","year":"2020","journal-title":"Asian J Psychiatry"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1016\/j.psycom.2024.100172","article-title":"Neurocognitive functions in siblings of patients with bipolar disorder","volume":"4","author":"Sari","year":"2024","journal-title":"Psychiatry Res Communications"}],"container-title":["Frontiers in Psychiatry"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpsyt.2025.1606988\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T05:22:47Z","timestamp":1750396967000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpsyt.2025.1606988\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,20]]},"references-count":80,"alternative-id":["10.3389\/fpsyt.2025.1606988"],"URL":"https:\/\/doi.org\/10.3389\/fpsyt.2025.1606988","relation":{},"ISSN":["1664-0640"],"issn-type":[{"type":"electronic","value":"1664-0640"}],"subject":[],"published":{"date-parts":[[2025,6,20]]},"article-number":"1606988"}}