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PGAD\/GPD exerts a profound negative impact on patients\u2019 physical and mental health, severely impairing daily functioning and, in some cases, leading to suicidal ideation. This case highlights the potential role of COVID-19 as a triggering factor in the development of PGAD\/GPD. The marked improvement in symptoms following treatment with leuprolide suggests that dysregulation of gonadotropin\/GnRH signaling may constitute a key pathogenic mechanism underlying this condition. We anticipate that this successful treatment case will provide valuable insights into the etiology and treatment strategies of PGAD\/GPD.<\/jats:p>","DOI":"10.3389\/fpsyt.2025.1623256","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T05:25:19Z","timestamp":1754371519000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Successful treatment of PGAD\/GPD with leuprolide: a case 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