{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:41:24Z","timestamp":1791999684517,"version":"4.4.0"},"reference-count":82,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Bipolar Disorder (BD) remains challenging to identify, and the Mood Disorder Questionnaire (MDQ) may capture heterogeneous forms of hyperactivation, including adaptive patterns unrelated to psychopathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine whether MDQ-positive individuals include a subgroup with adaptive hyperactivation\u2014characterized by high quality of life (QoL) and minimal psychiatric morbidity\u2014and to examine whether MDQ positivity also identifies diagnoses beyond BD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using data from a large Italian community survey with DSM-IV clinical interviews and MDQ screening, we conducted a case\u2013control analysis. MDQ-positive individuals were stratified by SF-12 QoL scores (&amp;gt;40 vs. \u226440), and matched MDQ-negative controls were selected by age and sex. Psychiatric diagnoses were compared using ANOVA and chi-square tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 91 MDQ-positive participants, 33% showed high QoL and exhibited markedly fewer psychiatric diagnoses than those with low QoL (\u03c7\u00b2=15.529, p&amp;lt;0.0001). High-QoL MDQ-positive individuals displayed psychiatric morbidity comparable to MDQ-negative controls, whereas low-QoL MDQ-positive individuals showed excess anxiety, obsessive\u2013compulsive, and eating disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>MDQ positivity identifies a heterogeneous population, including individuals with adaptive hyperactivation and preserved functioning. These findings highlight the need for more refined instruments capable of distinguishing adaptive from pathological hyperactivation and caution against over-pathologizing MDQ positivity in clinical and public health settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpsyt.2025.1626277","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T05:30:05Z","timestamp":1767591005000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Can adaptive hyperactivation result in a positive score on the Mood Disorder Questionnaire? 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