{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T04:14:03Z","timestamp":1784607243787,"version":"3.55.0"},"reference-count":77,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:00:00Z","timestamp":1755648000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>This Hungarian cross-sectional study examined patterns and differences in suicide risk factors across various suicidality groups, including individuals with single or multiple suicide attempts, as well as gender-specific variations. Additionally, it explored these risk factors within a biopsychosocial framework to offer a comprehensive understanding of their interconnected effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>A total of 300 psychiatric inpatients were recruited from P\u00e9terfy Sandor Hospital in Budapest, Hungary, including 146 individuals (48.67%) with a history of suicide attempts and 154 (51.33%) without such a history. Participants ranged in age from 18 to 85 years, with a mean age of 37.98 years (SD = 12.80 for suicide attempters, 13.72 for non-attempters). The overall sample comprised 83 males (27.7%) and 217 females (72.3%). Logistic regression analysis was conducted to assess the influence of demographic characteristics, life history variables, and psychiatric diagnoses on suicide risk, aiming to identify significant predictors of suicide attempts within a biopsychosocial framework.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Depression was the most prevalent psychiatric diagnosis in the sample. Significant predictors of suicide attempts included family history of suicide (OR = 2.283, <jats:italic>p<\/jats:italic> = 0.015), prescription drug misuse (OR = 1.900, <jats:italic>p<\/jats:italic> = 0.047), and nicotine dependence (OR = 1.869, <jats:italic>p<\/jats:italic> = 0.035). In repeated suicide attempts, bipolar disorder (OR = 5.761, <jats:italic>p<\/jats:italic> = 0.006), borderline personality disorder (OR = 5.132, <jats:italic>p<\/jats:italic> = 0.003), depression (OR = 4.064, <jats:italic>p<\/jats:italic> = 0.004), and job loss (OR = 4.348, <jats:italic>p<\/jats:italic> = 0.031) emerged as the strongest predictors. Among men, job loss (OR = 4.074, <jats:italic>p<\/jats:italic> = 0.014) was a prominent risk factor, while among women, having two or more children (OR = 2.740, <jats:italic>p<\/jats:italic> = 0.036) and a family history of suicide (OR = 2.459, <jats:italic>p<\/jats:italic> = 0.028) significantly increased suicide risk. Relationship conflict was also associated with higher risk in women (OR = 0.382, <jats:italic>p<\/jats:italic> = 0.035).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our research supports the notion that suicide risk factors interact with one another, and in certain cases, their effects may be synergistic\u2014mutually reinforcing\u2014rather than antagonistic. Similarly, protective factors also appear to amplify each other\u2019s impact, suggesting a cumulative and interactive model of both risk and resilience.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpsyt.2025.1626808","type":"journal-article","created":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T05:35:53Z","timestamp":1755668153000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Uncovering key biopsychosocial risk factors in non-violent suicide attempts: evidence from a Hungarian cross-sectional study"],"prefix":"10.3389","volume":"16","author":[{"given":"Noemi Monika","family":"Szeifert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barnab\u00e1s","family":"Ol\u00e1h","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Sebok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xenia","family":"Gonda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,8,20]]},"reference":[{"key":"B1","unstructured":"Suicide data"},{"key":"B2","unstructured":"Suicide worldwide in 2019"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1186\/1471-244X-9-45","article-title":"Risk factors for suicide in Hungary: a case-control study","volume":"9","author":"Almasi","year":"2009","journal-title":"BMC Psychiatry"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.20311\/stat2025.06.hu0517","article-title":"Long-term gender differences in completed suicide in Hungary 1955\u20132022: trends in absolute and relative inequalities","volume":"103","author":"Balint","year":"2025","journal-title":"Hung Stat Rev"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1186\/1744-859X-12-21","article-title":"Suicide in Hungary-epidemiological and clinical perspectives","volume":"12","author":"Rihmer","year":"2013","journal-title":"Ann Gen Psychiatry"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2013.02.010","article-title":"Affective temperament, history of suicide attempt and family history of suicide in general practice patients","volume":"149","author":"Rihmer","year":"2013","journal-title":"J Affect Disord"},{"key":"B7","first-page":"36","article-title":"Suicide in Hungary - 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