{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:04:29Z","timestamp":1793315069002,"version":"4.5.0"},"reference-count":108,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Psychiatric disorders and difficulties in emotional expression represent a major problem in the management of Huntington\u2019s Disease (HD). To improve patient follow-up, we propose to investigate the link between emotional expression and psychiatric symptoms, measured by the Problem Behaviors Assessment (PBA) scale. To this aim we developed the first emotional\/psychiatric speech corpus, emoHD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included 102 HD gene carriers and 35 healthy controls (HC). Psychiatric symptoms were assessed using PBA sub-scales for Depression, Irritability\/aggressivity, Apathy, and Obsessive\/compulsive symptoms. Speech was annotated using three emotional descriptors: primary emotions, affective phenomena, and activation levels. Affective phenomena labels were selected based on PBA statements by external participants unaware of the study\u2019s aims. We analyzed (1) emotional descriptors\u2019 relationships, (2) emotional expression differences between HD and HC, and (3) the associations between emotions and psychiatric symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>HD patients showed reduced emotional expressiveness than HC with more neutral activation levels (=0). Only the primary emotion \u201cangry\u201d was less expressed in HD compared to HC. In contrast they expressed more affective phenomena states like apathetic, confused, \u201cdepressed\u201d, \u201cdisoriented\u201d, \u201cfrustrated\u201d, and \u201cpessimistic\u201d than HC, whereas they expressed less \u201cother\u201d and \u201cirritable\u201d than HC. Expressed emotions were congruent with psychiatric symptoms (e.g., \u201canxious\u201d and \u201cnervous\u201d are positively associated with Depression PBA sub-scale; \u201cfrustrated\u201d with Irritability\/aggressivity PBA sub-scale).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We showed that speech is a promising marker for emotional\/psychiatric symptoms in HD, supporting future remote monitoring and personalized care strategies.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpsyt.2025.1633492","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T05:30:41Z","timestamp":1754976641000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Emotional speech markers of psychiatric disturbance in Huntington\u2019s disease"],"prefix":"10.3389","volume":"16","author":[{"given":"Lucie","family":"Chenain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Fabre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadrien","family":"Titeux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gra\u00e7a","family":"Morgado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia","family":"Youssov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chlo\u00e9","family":"Clavel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Catherine","family":"Bachoud-L\u00e9vi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,8,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"15005","DOI":"10.1038\/nrdp.2015.5","article-title":"Huntington disease","volume":"1","author":"Bates","year":"2015","journal-title":"Nat Rev Dis Primers"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60111-1","article-title":"Huntington\u2019s disease","volume":"369","author":"Walker","year":"2007","journal-title":"Lancet"},{"key":"B3","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.cortex.2017.02.019","article-title":"Embodied emotion impairment in Huntington\u2019s Disease","volume":"92","author":"Trinkler","year":"2017","journal-title":"Cortex"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1080\/02699930801949090","article-title":"Production of spontaneous and posed facial expressions in patients with Huntington\u2019s disease: Impaired communication of disgust","volume":"23","author":"Hayes","year":"2009","journal-title":"Cogn Emotion"},{"key":"B5","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.cortex.2022.05.024","article-title":"Emotion expression through spoken language in Huntington disease","volume":"155","author":"Gallezot","year":"2022","journal-title":"Cortex"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2015.10.001","article-title":"Social cognition in Huntington\u2019s disease: A meta-analysis","volume":"297","author":"Bora","year":"2016","journal-title":"Behav Brain Res SreeTestContent1"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2016.11.020","article-title":"Beyond emotion recognition deficits: A theory guided analysis of emotion processing in Huntington\u2019s disease","volume":"73","author":"Kordsachia","year":"2017","journal-title":"Neurosci Biobehav Rev"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(16)30144-4","article-title":"Changes in mental state and behaviour in Huntington\u2019s disease","volume":"3","author":"Eddy","year":"2016","journal-title":"Lancet Psychiatry"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.21834","article-title":"Association between neurological disorders and death by suicide in Denmark","volume":"323","author":"Erlangsen","year":"2020","journal-title":"JAMA"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2007.128728","article-title":"Detection of Huntington\u2019s disease decades before diagnosis: the Predict-HD study","volume":"79","author":"Paulsen","year":"2008","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"B11","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopsych.2006.11.034","article-title":"Psychiatric Symptoms in Huntington\u2019s Disease before Diagnosis: The Predict-HD Study","volume":"62","author":"Duff","year":"2007","journal-title":"Biol Psychiatry"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.2.452","article-title":"Rate of functional decline in Huntington\u2019s disease. 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