{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T21:02:54Z","timestamp":1780779774422,"version":"3.54.1"},"reference-count":76,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82001429, 82090034"],"award-info":[{"award-number":["82001429, 82090034"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC3300500, 2021YFC3300504"],"award-info":[{"award-number":["2021YFC3300500, 2021YFC3300504"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Non-Suicidal Self-Injury (NSSI) is a primary risk factor for suicide, but objective biomarkers to assess this risk are urgently needed. The \u201cprefrontal-limbic dysregulation\u201d model provides a neurobiological framework for self-injurious behaviors. This study aimed to identify resting-state neural markers of suicidal ideation severity in adolescents with NSSI and to build a predictive model for individualized risk assessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We recruited 64 adolescent psychiatric inpatients with NSSI. Suicidal ideation was measured using the Beck Scale for Suicide Ideation (BSI). Resting-state functional MRI (rs-fMRI) was used to measure spontaneous brain activity via the amplitude of low-frequency fluctuation (ALFF). We performed a whole-brain correlation analysis between ALFF and BSI scores. A support vector regression (SVR) model was then developed using the identified neural feature to predict individual BSI scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A significant negative correlation was found between BSI scores and ALFF values in the left Middle Frontal Gyrus (MFG). Lower spontaneous activity in this region was associated with more severe suicidal ideation. The SVR model, based on the left MFG ALFF values, successfully predicted individual BSI scores with significant accuracy (r = 0.492, p &amp;lt; 0.001), a finding confirmed by permutation testing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Diminished resting-state activity in the left MFG is a key neural correlate of suicidal ideation severity in adolescents with NSSI. The functional activity of the left MFG is a promising biomarker for suicide risk assessment and may serve as a potential target for novel neuromodulatory therapies in this high-risk population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpsyt.2025.1671813","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T08:19:24Z","timestamp":1762157964000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Resting-state spontaneous brain activity as a neural marker for suicidal ideation in adolescents with non-suicidal self-injury: a voxel-wise and machine learning study"],"prefix":"10.3389","volume":"16","author":[{"given":"Qianqian","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhishun","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongpeng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanghua","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongjian","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,11,3]]},"reference":[{"key":"B1","first-page":"1505","volume-title":"Diagnostic and statistical manual of mental disorders (DSM-5)","year":"2013"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1177\/070674371405901101","article-title":"Nonsuicidal self-injury: what we know, and what we need to know","volume":"59","author":"Klonsky","year":"2014","journal-title":"Can J Psychiatry"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2020.00008","article-title":"Nonsuicidal self-injury disorder in adolescents: clinical utility of the diagnosis using the clinical assessment of nonsuicidal self-injury disorder index","volume":"11","author":"Zetterqvist","year":"2020","journal-title":"Front Psychiatry"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2021.681985","article-title":"Influential factors of non-suicidal self-injury in an eastern cultural context: A qualitative study from the perspective of school mental health professionals","volume":"12","author":"Chen","year":"2021","journal-title":"Front Psychiatry"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1007\/s00787-023-02264-y","article-title":"The prevalence of self-injury in adolescence: a systematic review and meta-analysis","volume":"33","author":"Farkas","year":"2024","journal-title":"Eur Child Adolesc Psychiatry"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1186\/s40479-014-0024-3","article-title":"The longitudinal course of non-suicidal self-injury and deliberate self-harm: a systematic review of the literature","volume":"2","author":"Plener","year":"2015","journal-title":"Borderline Pers Disord Emot Dysregul"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.20935\/mhealthwellb7334","article-title":"A systematic review and meta-analysis of non-suicidal self-injury among incarcerated juveniles","volume":"1","author":"Barker","year":"2024","journal-title":"Academia Ment Health Well-Being"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2022.912441","article-title":"Global prevalence and characteristics of non-suicidal self-injury between 2010 and 2021 among a non-clinical sample of adolescents: A meta-analysis","volume":"13","author":"Xiao","year":"2022","journal-title":"Front Psychiatry"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.2021.225","article-title":"The effect of non-suicidal self-injury on suicidal ideation: A real-time monitoring study","volume":"221","author":"Herzog","year":"2022","journal-title":"Br J Psychiatry"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.12788\/cp.0251","article-title":"Risk factors for nonsuicidal self-injury: A review of the evidence","volume":"21","author":"Kothadia","year":"2022","journal-title":"CP"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1097\/NR9.0000000000000023","article-title":"Risk factors, theoretical models, and biological mechanisms of nonsuicidal self-injury: a brief review","volume":"2","author":"Yan","year":"2023","journal-title":"Interdiscip Nurs Res"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2022.101350","article-title":"Risk factors for non-suicidal self-injury (NSSI) in adolescents: A meta-analysis","volume":"46","author":"Wang","year":"2022","journal-title":"EClinicalMedicine"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2022.925672","article-title":"A resting state functional magnetic resonance imaging study of unmedicated adolescents with non-suicidal self-injury behaviors: evidence from the amplitude of low-frequency fluctuation and regional homogeneity indicator","volume":"13","author":"Zhou","year":"2022","journal-title":"Front Psychiatry"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1943-278X.2012.00094.x","article-title":"Self-concealment and suicidal behaviors","volume":"42","author":"Friedlander","year":"2012","journal-title":"Suicide Life Threat Behav"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1002\/jclp.22964","article-title":"Self-concealment and suicidality: Mediating roles of unmet interpersonal needs and attitudes toward help-seeking","volume":"76","author":"Hogge","year":"2020","journal-title":"J Clin Psychol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.comppsych.2014.12.011","article-title":"Non-suicidal self-injury and suicidal ideation as predictors of suicide attempts in adolescent girls: A multi-wave prospective study","volume":"58","author":"Scott","year":"2015","journal-title":"Compr Psychiatry"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ridd.2023.104566","article-title":"Psychosocial and neurocognitive correlates of suicidal thoughts and behaviours amongst siblings of persons with and without neurodevelopmental conditions","volume":"139","author":"Wolff","year":"2023","journal-title":"Res Dev Disabil"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2019.19101064","article-title":"Cortico-limbic interactions mediate adaptive and maladaptive responses relevant to psychopathology","volume":"176","author":"Kovner","year":"2019","journal-title":"Am J Psychiatry"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2020.06.002","article-title":"Neural correlates associated with suicide and non-suicidal self-injury in youth","volume":"89","author":"Auerbach","year":"2021","journal-title":"Biol Psychiatry"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2015.09.011","article-title":"Conceptualizing the neurobiology of non-suicidal self-injury from the perspective of the Research Domain Criteria Project","volume":"57","author":"Schreiner","year":"2015","journal-title":"Neurosci Biobehav Rev"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.3390\/life11080729","article-title":"Neuroimaging studies of nonsuicidal self-injury in youth: A systematic review","volume":"11","author":"Bra\u00f1as","year":"2021","journal-title":"Life (Basel)"},{"key":"B22","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/j.neubiorev.2011.08.005","article-title":"Anatomical insights into the interaction of emotion and cognition in the prefrontal cortex","volume":"36","author":"Ray","year":"2012","journal-title":"Neurosci Biobehav Rev"},{"key":"B23","doi-asserted-by":"publisher","first-page":"e2711","DOI":"10.1002\/brb3.2711","article-title":"Diffusion tensor imaging studies on subjects with suicidal thoughts and behaviors: A descriptive literature review","volume":"12","author":"Zangh\u00ec","year":"2022","journal-title":"Brain Behav"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10163561","article-title":"Examining the neurobiology of non-suicidal self-injury in children and adolescents: the role of reward responsivity","volume":"10","author":"Case","year":"2021","journal-title":"J Clin Med"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-008-1642-z","article-title":"The prefrontal cortex and the executive control of attention","volume":"192","author":"Rossi","year":"2009","journal-title":"Exp Brain Res"},{"key":"B26","doi-asserted-by":"publisher","first-page":"2558","DOI":"10.1038\/s41598-018-20923-y","article-title":"Prefrontal cortex modulates the correlations between brain-derived neurotrophic factor level, serotonin, and the autonomic nervous system","volume":"8","author":"Chang","year":"2018","journal-title":"Sci Rep"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2015.00758","article-title":"Cognitive control, emotional value, and the lateral prefrontal cortex","volume":"6","author":"Dixon","year":"2015","journal-title":"Front Psychol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1038\/s41398-021-01232-x","article-title":"Functional network alterations differently associated with suicidal ideas and acts in depressed patients: an indirect support to the transition model","volume":"11","author":"Wagner","year":"2021","journal-title":"Transl Psychiatry"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2023.1146944","article-title":"Abnormal amplitude of low-frequency fluctuation values as a neuroimaging biomarker for major depressive disorder with suicidal attempts in adolescents: A resting-state fMRI and support vector machine analysis","volume":"14","author":"Zhou","year":"2023","journal-title":"Front Psychol"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2023.1224914","article-title":"Reduced suicidality after electroconvulsive therapy is linked to increased frontal brain activity in depressed patients: a resting-state fMRI study","volume":"14","author":"Wang","year":"2023","journal-title":"Front Psychiatry"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2021.762343","article-title":"Alteration of whole brain ALFF\/fALFF and degree centrality in adolescents with depression and suicidal ideation after electroconvulsive therapy: A resting-state fMRI study","volume":"15","author":"Li","year":"2021","journal-title":"Front Hum Neurosci"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2023.1228260","article-title":"The amplitude of low-frequency fluctuation characteristics in depressed adolescents with suicide attempts: a resting-state fMRI study","volume":"14","author":"Hu","year":"2023","journal-title":"Front Psychiatry"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.152.5.660","article-title":"Validity and reliability of the chinese hamilton depression rating scale","volume":"152","author":"Zheng","year":"1988","journal-title":"Br J Psychiatry"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8341.1959.tb00467.x","article-title":"The assessment of anxiety states by rating","volume":"32","author":"Hamilton","year":"1959","journal-title":"Br J Med Psychol"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1037\/\/0022-006x.47.2.343","article-title":"Assessment of suicidal intention: the Scale for Suicide Ideation","volume":"47","author":"Beck","year":"1979","journal-title":"J Consult Clin Psychol"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1590\/2237-6089-2019-0092","article-title":"Instruments to assess suicide risk: a systematic review","volume":"42","author":"Andreotti","year":"2020","journal-title":"Trends Psychiatry Psychother"},{"key":"B37","article-title":"Reliability and validity of the Chinese version of Beck Scale for Suicide Ideation (BSI-CV) among university students","volume":"25","author":"Li","year":"2011","journal-title":"Chin Ment Health J"},{"key":"B38","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1186\/s12888-023-04739-3","article-title":"Suicidal ideation in Chinese adults with schizophrenia: associations with neurocognitive function and empathy","volume":"23","author":"Liu","year":"2023","journal-title":"BMC Psychiatry"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.scib.2019.05.008","article-title":"RESTplus: an improved toolkit for resting-state functional magnetic resonance imaging data processing","volume":"64","author":"Jia","year":"2019","journal-title":"Sci Bull (Beijing)"},{"key":"B40","article-title":"Statistical parametric mapping: the analysis of functional brain images","volume":"689","author":"Penny","year":"2011","journal-title":"Elsevier"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1007\/s12149-012-0625-0","article-title":"Correlation between neuropsychological tests and hypoperfusion in MCI patients: anatomical labeling using xjView and Talairach Daemon software","volume":"26","author":"Yoon","year":"2012","journal-title":"Ann Nucl Med"},{"key":"B42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1145\/1961189.1961199","article-title":"LIBSVM: A library for support vector machines","volume":"2","author":"Chang","year":"2011","journal-title":"ACM Trans Intell Syst Technol"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2019.112553","article-title":"Self-harm as a predisposition for suicide attempts: A study of adolescents\u2019 deliberate self-harm, suicidal ideation, and suicide attempts","volume":"287","author":"Duarte","year":"2020","journal-title":"Psychiatry Res"},{"key":"B44","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1016\/j.psychres.2015.05.001","article-title":"Behavioral and emotional responses to interpersonal stress: A comparison of adolescents engaged in non-suicidal self-injury to adolescent suicide attempters","volume":"228","author":"Kim","year":"2015","journal-title":"Psychiatry Res"},{"key":"B45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1017\/S095457942500001X","article-title":"The association between nonsuicidal and suicidal self-injurious behaviors: A systematic review and expanded conceptual model","author":"Ammerman","year":"2025","journal-title":"Dev Psychopathol"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1521\/suli.2010.40.3.266","article-title":"Capable of suicide: A functional model of the acquired capability component of the interpersonal-psychological theory of suicide","volume":"40","author":"Smith","year":"2010","journal-title":"Suicide Life Threat Behav"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.5765\/jkacap.230033","article-title":"Non-suicidal self-injury and emotional dysregulation in male and female young adults: A qualitative study","volume":"34","author":"Thomas","year":"2023","journal-title":"J Korean Acad Child Adolesc Psychiatry"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/326507","article-title":"Thresholds and tolerance of physical pain among young adults who self-injure","volume":"15","author":"McCoy","year":"2010","journal-title":"Pain Res Manag"},{"key":"B49","doi-asserted-by":"publisher","first-page":"e0227021","DOI":"10.1371\/journal.pone.0227021","article-title":"Percent amplitude of fluctuation: A simple measure for resting-state fMRI signal at single voxel level","volume":"15","author":"Jia","year":"2020","journal-title":"PloS One"},{"key":"B50","doi-asserted-by":"publisher","first-page":"e0128117","DOI":"10.1371\/journal.pone.0128117","article-title":"Low-frequency fluctuations of the resting brain: high magnitude does not equal high reliability","volume":"10","author":"Mao","year":"2015","journal-title":"PloS One"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1216-21.2022","article-title":"Subregions of DLPFC display graded yet distinct structural and functional connectivity","volume":"42","author":"Jung","year":"2022","journal-title":"J Neurosci"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2021.645209","article-title":"The role of the dorsolateral prefrontal cortex for speech and language processing","volume":"15","author":"Hertrich","year":"2021","journal-title":"Front Hum Neurosci"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1177\/23982128211007769","article-title":"Hot and cold executive functions in the brain: A prefrontal-cingular network","volume":"5","author":"Salehinejad","year":"2021","journal-title":"Brain Neurosci Adv"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2017.10.042","article-title":"Interaction of the left dorsolateral prefrontal cortex (l-DLPFC) and right orbitofrontal cortex (OFC) in hot and cold executive functions: evidence from transcranial direct current stimulation (tDCS)","volume":"369","author":"Nejati","year":"2018","journal-title":"Neuroscience"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2022.108442","article-title":"Functional significance of the dorsolateral prefrontal cortex during exhaustive exercise","volume":"175","author":"Bigliassi","year":"2022","journal-title":"Biol Psychol"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcab125","article-title":"The role of the medial prefrontal cortex in cognition, ageing and dementia","volume":"3","author":"Jobson","year":"2021","journal-title":"Brain Commun"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2007.05.031","article-title":"The neural bases of emotion regulation: reappraisal and suppression of negative emotion","volume":"63","author":"Goldin","year":"2008","journal-title":"Biol Psychiatry"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2014.11.034","article-title":"Prefrontal engagement by cognitive reappraisal of negative faces","author":"Nelson","year":"2015","journal-title":"Behav Brain Res"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.4306\/pi.2017.14.6.904","article-title":"Frontal lobe dysfunction in a depressed patient who survived a suicide attempt by jumping from the bridge on the han river","volume":"14","author":"Kim","year":"2017","journal-title":"Psychiatry Investig"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-019-0587-x","article-title":"Imaging suicidal thoughts and behaviors: a comprehensive review of 2 decades of neuroimaging studies","volume":"25","author":"Schmaal","year":"2020","journal-title":"Mol Psychiatry"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2019.00445","article-title":"The role of prefrontal cortical surface area and volume in preclinical suicidal ideation in a non-clinical sample","volume":"10","author":"Bajaj","year":"2019","journal-title":"Front Psychiatry"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.220046","article-title":"Altered coordination between frontal delta and parietal alpha networks underlies anhedonia and depressive rumination in major depressive disorder","volume":"47","author":"Chao","year":"2022","journal-title":"J Psychiatry neuroscience : JPN"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1186\/2045-5380-2-2","article-title":"Rumination in bipolar disorder: evidence for an unquiet mind","volume":"2","author":"Ghaznavi","year":"2012","journal-title":"Biol Mood Anxiety Disord"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-019-0615-x","article-title":"Neuroplasticity in cognitive and psychological mechanisms of depression: An integrative model","volume":"25","author":"Price","year":"2020","journal-title":"Mol Psychiatry"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci13060882","article-title":"Irritability moderates the association between cognitive flexibility task performance and related prefrontal cortex activation in young children","volume":"13","author":"Li","year":"2023","journal-title":"Brain Sci"},{"key":"B66","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1017\/neu.2019.45","article-title":"Dorsolateral and ventrolateral prefrontal cortex structural changes relative to suicidal ideation in patients with depression","volume":"32","author":"Zhang","year":"2020","journal-title":"Acta Neuropsychiatr"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2016.15050652","article-title":"Multimodal neuroimaging of frontolimbic structure and function associated with suicide attempts in adolescents and young adults with bipolar disorder","volume":"174","author":"Johnston","year":"2017","journal-title":"Am J Psychiatry"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2018.11.095","article-title":"Gray and white matter differences in adolescents and young adults with prior suicide attempts across bipolar and major depressive disorders","volume":"245","author":"Fan","year":"2019","journal-title":"J Affect Disord"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291712002966","article-title":"Differential patterns of activity and functional connectivity in emotion processing neural circuitry to angry and happy faces in adolescents with and without suicide attempt","volume":"43","author":"Pan","year":"2013","journal-title":"Psychol Med"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8986.2012.01443.x","article-title":"A brain network instantiating approach and avoidance motivation","volume":"49","author":"Spielberg","year":"2012","journal-title":"Psychophysiology"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.3758\/s13415-012-0088-8","article-title":"Trait motivation moderates neural activation associated with goal pursuit","volume":"12","author":"Spielberg","year":"2012","journal-title":"Cognit Affect Behav Neurosci"},{"key":"B72","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1002\/wps.20998","article-title":"Psychiatric diagnosis and treatment in the 21st century: paradigm shifts versus incremental integration","volume":"21","author":"Stein","year":"2022","journal-title":"World Psychiatry"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2018.00242","article-title":"Neuromarkers for mental disorders: harnessing population neuroscience","volume":"9","author":"Jollans","year":"2018","journal-title":"Front Psychiatry"},{"key":"B74","unstructured":"A longitudinal study examining three RDoC constructs in adolescents with non-suicidal self-injury\n          \n          \n          clinicaltrials.gov\n          \n          2025"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-023-02195-9","article-title":"A meta-analysis and systematic review of single vs. multimodal neuroimaging techniques in the classification of psychosis","volume":"28","author":"Porter","year":"2023","journal-title":"Mol Psychiatry"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000967","article-title":"Data-driven approaches to neuroimaging biomarkers for neurological and psychiatric disorders: emerging approaches and examples","volume":"34","author":"Calhoun","year":"2021","journal-title":"Curr Opin Neurol"}],"container-title":["Frontiers in Psychiatry"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpsyt.2025.1671813\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T08:19:28Z","timestamp":1762157968000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpsyt.2025.1671813\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,3]]},"references-count":76,"alternative-id":["10.3389\/fpsyt.2025.1671813"],"URL":"https:\/\/doi.org\/10.3389\/fpsyt.2025.1671813","relation":{},"ISSN":["1664-0640"],"issn-type":[{"value":"1664-0640","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,3]]},"article-number":"1671813"}}