{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:54:43Z","timestamp":1781106883034,"version":"3.54.1"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T00:00:00Z","timestamp":1765238400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study examined the associations between the Triglyceride-Glucose (TyG) index and its combined indices (TyG-BMI, TyG-WC, TyG-WHtR) with non-suicidal self-injury (NSSI) in adolescents with Major Depressive Disorder (MDD). It also explored whether sleep quality mediated these relationships.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A total of 157 adolescents (12\u201318 years) with MDD were recruited. Participants were divided into NSSI (n = 78) and non-NSSI (n = 79) groups based on DSM-5 criteria. The TyG index and its derivatives were calculated from fasting blood samples. Analyses included multivariable logistic regression, restricted cubic spline (RCS) analysis, mediation analysis, and receiver operating characteristic (ROC) curves.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The NSSI group had higher TyG index values (Median [Q\n                      <jats:sub>1<\/jats:sub>\n                      , Q\n                      <jats:sub>3<\/jats:sub>\n                      ]: 8.23 [7.95, 8.45]) than the non-NSSI group (7.73 [7.33, 8.21],\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&amp;lt;\u00a00.001). Adjusted regression models confirmed significant associations between TyG indices and NSSI (e.g., TyG: OR\u00a0=\u00a03.50, 95% CI: 1.82\u20136.74,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&amp;lt;\u00a00.001), especially in female adolescents. Sleep quality partially mediated the link between TyG and NSSI (proportion mediated = 17.1%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.026). ROC analysis showed moderate predictive accuracy for TyG-WC (AUC\u00a0=\u00a00.745, 95% CI: 0.666\u20130.824).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The TyG index and its combined indices are positively associated with NSSI in adolescents with MDD. Sleep quality partially mediates this relationship. These indices may serve as low-cost markers for early identification of adolescents at risk for NSSI in clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpsyt.2025.1689128","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T06:29:46Z","timestamp":1765261786000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Associations of the triglyceride-glucose index and its combined indices with non-suicidal self-injury in adolescents with depressive disorders: the mediating role of sleep 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