{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T05:04:47Z","timestamp":1781586287014,"version":"3.54.5"},"reference-count":7,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Persistent Genital Arousal Disorder (PGAD) is a rare and distressing condition characterized by persistent genital arousal in the absence of sexual desire. We present a unique case of a menopausal woman who developed PGAD after combined pharmacotherapy with trazodone, pregabalin, vaginal estriol, and depot medroxyprogesterone acetate (DMPA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The patient underwent comprehensive gynecological, neurological, and psychiatric evaluation. Menopausal status was confirmed by laboratory findings. A detailed pharmacological review was conducted to assess possible interactions affecting serotonergic, neuronal, and hormonal regulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>PGAD symptoms emerged shortly after initiating the combination of these medications. Each drug has been individually associated with alterations in sexual function, but their concurrent use may have produced synergistic effects on neuroendocrine pathways. Gradual discontinuation of all medications resulted in complete remission of symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case supports the hypothesis that combined modulation of serotonergic, neuronal, and hormonal systems can trigger PGAD in predisposed menopausal women. Recognition of potential pharmacological interactions is crucial for diagnosis and management of PGAD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpsyt.2025.1709728","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T14:09:14Z","timestamp":1764079754000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Case Report: Development of persistent genital arousal disorder due to a possible combination of medications"],"prefix":"10.3389","volume":"16","author":[{"given":"Ludek","family":"Fiala","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u0159\u00ed","family":"Lenz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,11,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsxm.2021.01.172","article-title":"ISSWSH consensus nomenclature and pathophysiology of PGAD","volume":"18","author":"Goldstein","year":"2021","journal-title":"J Sexual Med"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.esxm.2021.100335","article-title":"Healthcare experiences of individuals with PGAD\/GPD","author":"Jackowich","year":"2021","journal-title":"Sexual Med"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1258\/095646206776253480","article-title":"Persistent genital arousal in women \u2013 a new syndrome entity","author":"Goldmeier","year":"2006","journal-title":"Int J STD AIDS"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1097\/PR9.0000000000000801","article-title":"PGAD as a special sense neuropathy","author":"Oaklander","year":"2020","journal-title":"Pain Rep"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.sxmr.2021.05.001","article-title":"Persistent genital arousal disorder: A multidisciplinary management review","volume":"10","author":"Pease","year":"2022","journal-title":"Sexual Med Rev"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1007\/s11930-017-0122-5","article-title":"Neurophysiology of genital arousal disorders","volume":"9","author":"Komisaruk","year":"2023","journal-title":"Front Neurosci"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1207\/s15327752jpa6703_13","article-title":"Comparison of Beck Depression Inventories -IA and -II in psychiatric outpatients","author":"Beck","year":"1996","journal-title":"J Pers Assessment"}],"container-title":["Frontiers in Psychiatry"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpsyt.2025.1709728\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T14:09:15Z","timestamp":1764079755000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpsyt.2025.1709728\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,25]]},"references-count":7,"alternative-id":["10.3389\/fpsyt.2025.1709728"],"URL":"https:\/\/doi.org\/10.3389\/fpsyt.2025.1709728","relation":{},"ISSN":["1664-0640"],"issn-type":[{"value":"1664-0640","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,25]]},"article-number":"1709728"}}