{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:31:44Z","timestamp":1791304304069,"version":"4.3.1"},"reference-count":74,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Transgender and gender-expansive people experience high rates of depression, anxiety, and trauma-related distress, yet few evidence-based interventions are tailored to their needs.\n                      <jats:italic>Kindred<\/jats:italic>\n                      is a novel, group-based ketamine-assisted psychotherapy (KAP) program that integrates cognitive processing therapy (CPT) to address identity-based trauma.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This mixed-methods pilot study evaluated the feasibility, acceptability, and preliminary effects of\n                      <jats:italic>Kindred<\/jats:italic>\n                      among eight transgender and gender-expansive adults. The nine-week group KAP intervention alternated ketamine dosing sessions with CPT-based cognitive skills-building and integration sessions in a community-based clinical setting. Quantitative measures assessed changes in mood, cognitive fusion, substance use, suicidality, trauma symptoms, and gender-related well-being from pre- to post-intervention, while qualitative interviews explored participants\u2019 experiences and perceived mechanisms of change.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The intervention was feasible and highly acceptable, with 100% retention and high satisfaction ratings. Participants reported significant reductions in depression, anxiety, and cognitive fusion scores, alongside qualitative reports of decreased shame, suicidality, and internalized transphobia. Participants reported that group belonging, peer validation, and shared identity were important therapeutic factors that enhanced the impact of ketamine and CPT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>\n                      Findings suggest that\n                      <jats:italic>Kindred<\/jats:italic>\n                      is a feasible and promising intervention for addressing mental health symptoms of identity-based trauma among TGE adults. Integrating evidence-based psychotherapy, such as CPT, with KAP in a group setting may promote synergistic cognitive, emotional, and social mechanisms of healing while facilitating increased accessibility.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpsyt.2025.1727487","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T06:54:39Z","timestamp":1769064879000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Ketamine-assisted group psychotherapy integrating cognitive processing therapy to address identity-based trauma: a pilot study"],"prefix":"10.3389","volume":"16","author":[{"given":"Jae M.","family":"Sevelius","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Columbia University Irving Medical Center","place":["New York, NY, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel Lynn","family":"Golden","sequence":"additional","affiliation":[{"name":"Golden Psychology","place":["New York, NY, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brooke L.","family":"Stott","sequence":"additional","affiliation":[{"name":"Columbia University, School of Social Work","place":["New York, NY, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natavi Orion","family":"Kozicz","sequence":"additional","affiliation":[{"name":"Golden Psychology","place":["New York, NY, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronica","family":"Mukerjee","sequence":"additional","affiliation":[{"name":"Columbia University Irving Medical Center, School of Nursing","place":["New York, NY, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina R.","family":"Cluesman","sequence":"additional","affiliation":[{"name":"HIV Center for Clinical and Behavioral Studies, Division of Gender, Sexuality, and Health, Columbia University Irving Medical Center and the New York State Psychiatric Institute","place":["New York, NY, United States"]},{"name":"Center for Drug Use and HIV Research, School of Global Public Health, New York University","place":["New York, NY, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tennessee","family":"Jones","sequence":"additional","affiliation":[{"name":"Golden Psychology","place":["New York, NY, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talea","family":"Cornelius","sequence":"additional","affiliation":[{"name":"Center for Behavioral Cardiovascular Health, Columbia University Irving Medical Center","place":["New York, NY, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1111\/papt.12596","article-title":"Cisnormativity and the frustration of core emotional needs among transgender and gender diverse individuals","volume":"98","author":"Radford","year":"2025","journal-title":"Psychol Psychother"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1080\/00918369.2019.1591789","article-title":"Gender minority stress: A critical review","volume":"67","author":"Tan","year":"2020","journal-title":"J Homosexuality"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1080\/00224499.2019.1608422","article-title":"Invalidation experiences among non-binary adolescents","volume":"57","author":"Johnson","year":"2020","journal-title":"J Sex Res"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1017\/S1754470X18000235","article-title":"Applying dialectical behaviour therapy to structural and internalized stigma with LGBTQ+ clients","volume":"12","author":"Skerven","year":"2019","journal-title":"Cogn Behav Therapist"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1037\/cou0000759","article-title":"Associations between misgendering, invalidation, pride, community connectedness, and trauma among nonbinary adults","volume":"71","author":"Colson","year":"2024","journal-title":"J Couns Psychol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ssmmh.2024.100304","article-title":"Parental Gender Affirmation Model: A culturally informed framework","volume":"5","author":"Vance","year":"2024","journal-title":"SSM - 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