{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:09:30Z","timestamp":1790633370640,"version":"4.1.0"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To improve treatment outcomes and enhance the prognosis of patients with PTSD (Post-Traumatic Stress Disorder), the efficacy and patient acceptance of antidepressant treatment for PTSD are comprehensively evaluated, and its clinical application value is explored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective study is conducted, with 200 patients divided into a medication group and a combination group, with 100 patients in each group. The medication group receives a single antidepressant (primarily a selective serotonin reuptake inhibitor) for 8 weeks, while the combination group receives the same medication plus a 60-minute weekly trauma-focused cognitive behavioral therapy (TF-CBT). Symptom severity, side effects, and adherence are assessed using standardized clinical interviews and self-rating scales. Correlation analysis and multiple linear regression (MLR) are used to explore the relationships between these indicators.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The combination group has higher medication satisfaction (\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt; 0.001), lower frequency of side effects (insomnia: 0.70 \u00b1 0.42 times\n                      <jats:italic>vs<\/jats:italic>\n                      . 1.25 \u00b1 0.47 times,\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt; 0.001), and higher medication compliance rate (93.0%\n                      <jats:italic>vs<\/jats:italic>\n                      . 85.0%,\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt; 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Compared with antidepressant monotherapy, combining antidepressant and CBT treatment significantly alleviates patient symptoms, reduces side effects, and improves treatment adherence and satisfaction. This study provides a new perspective for tailoring treatment plans and improving treatment precision and effectiveness.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpsyt.2025.1737322","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T08:34:25Z","timestamp":1768206865000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Comprehensive evaluation of the efficacy and patient acceptance of combined antidepressant and cognitive behavioral therapy in the treatment of post-traumatic stress 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