{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:45:50Z","timestamp":1771461950532,"version":"3.50.1"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Elderly major depressive disorder (MDD) patients often exhibit complex symptomatology and high rates of abnormal lipid metabolism (ALM), yet predictors of abnormal thyroid function in those with co-occurring lipid metabolism are not fully elucidated. This study aimed to investigate the relationship between thyroid function and ALM in first-episode, drug-na\u00efve (FEDN) elderly MDD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>1,029 elderly FEDN MDD patients were enrolled. Demographics, lipid profile (TC, TG, LDL-C, HDL-C), thyroid parameters (TSH, FT3, FT4, TG-Ab, TPO-Ab), and symptom ratings (HAMD, HAMA, PANSS-positive) were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Prevalence of abnormal thyroid function was 69.0%. Compared with ALM patients without thyroid dysfunction, those affected had higher HAMD, HAMA, and PANSS-positive scores, more suicide attempts, severe anxiety, and psychotic symptoms (all P &amp;lt; 0.05). Logistic regression identified BMI (OR = 1.186), HAMD score (OR = 1.201), blood glucose (OR = 4.03), TC (OR = 1.683), and LDL-C (OR = 1.299) were independent associated factors for abnormal thyroid function in MDD patients with comorbid ALM(all P &amp;lt; 0.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Abnormal thyroid function is highly prevalent in elderly FEDN MDD patients with ALM; clinical severity, glucose, and lipid levels contribute to this comorbidity. These findings suggest that elderly, first-episode MDD patients with dyslipidemia, particularly those with elevated BMI, high blood glucose, and severe depressive symptoms, should undergo routine screening for thyroid dysfunction to facilitate early intervention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpsyt.2025.1742901","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T16:32:57Z","timestamp":1768235577000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Thyroid dysfunction in elderly first-episode drug-na\u00efve major depressive disorder patients with comorbid dyslipidemia: prevalence, clinical profile and associated 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