{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T07:13:51Z","timestamp":1771312431912,"version":"3.50.1"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Suicide risk in patients with depressive disorder (DD) and panic disorder with or without agoraphobia (PD\/A) is often associated with depression, hopelessness, and anxiety-related factors, but their predictive roles remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To identify the strongest clinical predictors of suicide attempts in patients with DD and PD\/A, and to assess the applicability of a predictive model within and across diagnostic groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 94 patients (48 with DD- acute or recurrent, 46 with PD\/A) were assessed using the Beck Scale for Suicide Ideation (BSSI), Beck Depression Inventory-II (BDI-II), Beck Hopelessness Scale (BHS), Anxiety Sensitivity Index-Revised (ASI-R), and Beck Anxiety Inventory (BAI). Univariate and multivariate analyses were conducted to evaluate the relative predictive value of these factors for suicide attempts within and across diagnostic groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Suicide attempts were reported by 23 patients with DD (48%) and only one patient with PD\/A (2.17%). In DD sample, suicidal ideation was the strongest predictor of suicide attempts, followed by depression severity. ROC analyses indicated optimal cut-offs of 11 for BSSI and 35 for BDI-II, yielding high sensitivity (82.6%) and specificity (92%). Hopelessness and anxiety sensitivity did not retain predictive value in multivariate analysis, whereas panic\/agoraphobic symptoms showed a suppressor effect, reducing risk by 11%. When applied to the PD\/A group, the model estimated an average predicted risk of 9.3%, but failed to identify the single attempter, resulting in zero sensitivity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>High levels of suicidal ideation and depressive symptoms were the strongest predictors of suicide attempts in DD. Panic and agoraphobic symptoms exerted a suppressor effect on suicide risk. In the PD\/A group, however, the model\u2019s predictive utility was extremely limited due to the very low number of suicide attempts, and these findings should therefore be considered preliminary.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpsyt.2026.1710182","type":"journal-article","created":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T06:33:15Z","timestamp":1771309995000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Prediction of suicide attempts in depressive disorder and panic disorder with\/without agoraphobia: multivariate analysis of clinical predictors"],"prefix":"10.3389","volume":"17","author":[{"given":"Borjanka","family":"Batinic","sequence":"first","affiliation":[{"name":"Faculty of Philosophy, Department of Psychology, University of Belgrade","place":["Belgrade, Serbia"]},{"name":"Clinic of Psychiatry, University Clinical Centre of Serbia","place":["Belgrade, 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