{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T19:22:15Z","timestamp":1793128935878,"version":"4.5.0"},"reference-count":55,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["AC22\/00010"],"award-info":[{"award-number":["AC22\/00010"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>While psychological interventions are effective at improving symptoms of psychosis, accessible, cost- and time-efficient treatments remain limited. Personalized medicine has emerged as a promising approach, tailoring interventions to individual needs. Metacognitive Training (MCT), with its established efficacy and adaptable format, is well-suited for personalization. The PERMEPSY project (Towards a Personalized Medicine Approach to Psychological Treatment for Psychosis) aims to deliver tailored MCT intervention for individuals with psychosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PERMEPSY is an international study funded by ERAPerMed (JTC2022) involving five clinical partners (Spain, Chile, France, Germany, Poland) and one technological partner (Spain). The project involves a proof-of-concept clinical trial recruiting 51 participants from each center for a total of 255 adult participants with psychosis in a prospective study (Registration: NCT06603922, 19-09-2024). The trial will test the efficacy of a Machine Learning (ML)-derived platform at predicting clinical and functional outcomes from baseline scores and compare a personalized MCT (P-MCT) to a classical MCT based on the platform\u2019s predictions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>PERMEPSY seeks to (1) develop and test the predictive power of an algorithm that could support decision-making, and (2) ascertain whether P-MCT is more effective than MCT at improving key symptoms and cognitive impairments associated to psychosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A harmonized retrospective database enabled the development of a predictive ML algorithm, integrated into an innovative platform. This platform provides clinicians with the information needed to deliver P-MCT. Predictions include changes in positive symptoms (e.g., delusions), insight, self-esteem, and treatment adherence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>By integrating diverse data types and innovative technology, PERMEPSY addresses the need for personalized, effective treatment in psychosis, aiming to reduce individual and systemic burdens while supporting clinicians in their decision-making.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpsyt.2026.1711659","type":"journal-article","created":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T15:26:36Z","timestamp":1772810796000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["PERMEPSY: a multicentre, randomized, double-blind proof-of-concept trial of personalized metacognitive training for adults with psychosis \u2014 a study protocol"],"prefix":"10.3389","volume":"17","author":[{"given":"Maria","family":"Lamarca","sequence":"first","affiliation":[{"name":"Research Unit, Parc Sanitari Sant Joan de D\u00e9u, Sant Boi de Llobregat","place":["Barcelona, Spain"]},{"name":"Grup Etiopathogenesis and Treatment of Severe Mental Disorders (MERITT), Fundaci\u00f3 Sant Joan de D\u00e9u, Institut de Recerca Sant Joan de D\u00e9u, Esplugues de Llobregat","place":["Barcelona, Spain"]},{"name":"Consorcio de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III","place":["Madrid, Spain"]},{"name":"Departament de Psicologia Cl\u00ednica i de la Salut, Facultat de Psicologia, Universitat Aut\u00f2noma de Barcelona, Bellaterra, Cerdanyola del Vall\u00e8s","place":["Barcelona, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Requejo","sequence":"additional","affiliation":[{"name":"Research Unit, Parc Sanitari Sant Joan de D\u00e9u, Sant Boi de Llobregat","place":["Barcelona, Spain"]},{"name":"Grup Etiopathogenesis and Treatment of Severe Mental Disorders (MERITT), Fundaci\u00f3 Sant Joan de D\u00e9u, Institut de Recerca Sant Joan de D\u00e9u, Esplugues de Llobregat","place":["Barcelona, Spain"]},{"name":"Facultad de Psicolog\u00eda, Universitat de Barcelona","place":["Barcelona, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrianna","family":"Aleksandrowicz","sequence":"additional","affiliation":[{"name":"II Department of Psychiatry, Medical University of Warsaw","place":["Warsaw, Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrien","family":"Goncalves","sequence":"additional","affiliation":[{"name":"University of Strasbourg","place":["Inserm, Strasbourg, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martyna","family":"Kre\u017co\u0142ek","sequence":"additional","affiliation":[{"name":"II Department of Psychiatry, Medical University of Warsaw","place":["Warsaw, Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Gelner","sequence":"additional","affiliation":[{"name":"II Department of Psychiatry, Medical University of Warsaw","place":["Warsaw, Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justyna","family":"Piwi\u0144ska","sequence":"additional","affiliation":[{"name":"II Department of Psychiatry, Medical University of Warsaw","place":["Warsaw, Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabea","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf","place":["Hamburg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merle","family":"Schlechte","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf","place":["Hamburg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro","family":"Cavieres","sequence":"additional","affiliation":[{"name":"Departamento de Psiquiatr\u00eda, Escuela de Medicina, Facultad de Medicina, Universidad de Valpara\u00edso","place":["Valpara\u00edso, Chile"]},{"name":"Unidad de Trastornos Psic\u00f3ticos. 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