{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T11:21:23Z","timestamp":1787743283572,"version":"build-2784847793"},"reference-count":166,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:p>Anxiety is an adaptive response essential for survival that integrates external stimuli, internal states, memory, and decision making to respond to perceived threats. When dysregulated, it can become excessive and persistent, contributing to psychiatric and neurological disorders. The anterior cingulate cortex (ACC) integrates cognitive, emotional, interoceptive, and autonomic information and serves as a key hub in anxiety-related circuits. However, its subregion- and pathway-specific roles remain incompletely integrated across species. This review examines the cytoarchitectural and cellular organization of ACC subregions and their proposed correspondence in humans, non-human primates, and rodents. We then review ACC connectivity with the amygdala, hippocampus, insula, and bed nucleus of the stria terminalis and propose an integrative model in which ACC effects depend on subregion, projection target, and behavioral context. We also summarize structural, functional, connectivity, and neurochemical alterations of the ACC in anxiety-related disorders and neurodegenerative diseases with prominent anxiety symptoms. Finally, we discuss the strengths and limitations of rodent and non-human-primate models and identify priorities for future mechanistic and translational studies. Together, this review provides a timely and comprehensive view of the ACC\u2019s role in adaptive and pathological anxiety and offers a framework for advancing mechanistic and translational research.<\/jats:p>","DOI":"10.3389\/fpsyt.2026.1719721","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:45:45Z","timestamp":1787741145000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The role of the anterior cingulate cortex in anxiety control, from circuits to disorders"],"prefix":"10.3389","volume":"17","author":[{"given":"Emily","family":"Dew","sequence":"first","affiliation":[{"name":"Department of Neuroscience and Regenerative Medicine, Medical College of Georgia at Augusta University","place":["Augusta, GA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Regenerative Medicine, Medical College of Georgia at Augusta University","place":["Augusta, GA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shalini","family":"Saggu","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Regenerative Medicine, Medical College of Georgia at Augusta University","place":["Augusta, GA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Pozzo-Miller","sequence":"additional","affiliation":[{"name":"Department of Pediatrics & Human Development, College of Human Medicine, Michigan State University","place":["Grand Rapids, MI, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Regenerative Medicine, Medical College of Georgia at Augusta University","place":["Augusta, GA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-009-0215-z","article-title":"Anxiety in mice and men: A comparison","volume":"116","author":"Hohoff","year":"2009","journal-title":"J Neural Transm (Vienna)"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.22744","article-title":"Anxiety disorders: A review","volume":"328","author":"Szuhany","year":"2022","journal-title":"Jama"},{"key":"B3","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1038\/nrn3524","article-title":"Uncertainty and anticipation in anxiety: An integrated neurobiological and psychological perspective","volume":"14","author":"Grupe","year":"2013","journal-title":"Nat Rev Neurosci"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3945","article-title":"Neuronal circuits for fear and anxiety","volume":"16","author":"Tovote","year":"2015","journal-title":"Nat Rev Neurosci"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/nature14366","article-title":"A circuit mechanism for differentiating positive and negative associations","volume":"520","author":"Namburi","year":"2015","journal-title":"Nature"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2016.16030353","article-title":"Using neuroscience to help understand fear and anxiety: A two-system framework","volume":"173","author":"LeDoux","year":"2016","journal-title":"Am J Psychiatry"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4101","article-title":"Resolving the neural circuits of anxiety","volume":"18","author":"Calhoon","year":"2015","journal-title":"Nat Neurosci"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2019.09.009","article-title":"Conserved features of anterior cingulate networks support observational learning across species","volume":"107","author":"Burgos-Robles","year":"2019","journal-title":"Neurosci Biobehav Rev"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2020.03.007","article-title":"Where is cingulate cortex? A cross-species view","volume":"43","author":"van Heukelum","year":"2020","journal-title":"Trends Neurosci"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-32-9705-0_12","article-title":"Anxiety disorders in the Dsm-5: Changes, controversies, and future directions","volume":"1191","author":"Park","year":"2020","journal-title":"Adv Exp Med Biol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(06)69418-x","article-title":"Panic disorder","volume":"368","author":"Roy-Byrne","year":"2006","journal-title":"Lancet"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2016.108","article-title":"A trans-diagnostic review of anxiety disorder comorbidity and the impact of multiple exclusion criteria on studying clinical outcomes in anxiety disorders","volume":"6","author":"Goldstein-Piekarski","year":"2016","journal-title":"Transl Psychiatry"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.12.1475","article-title":"Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: Results from the cardiovascular health study","volume":"288","author":"Lyketsos","year":"2002","journal-title":"Jama"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22589","article-title":"Neuropsychiatric symptoms in Parkinson's disease","volume":"24","author":"Aarsland","year":"2009","journal-title":"Mov Disord"},{"key":"B15","doi-asserted-by":"publisher","first-page":"67","DOI":"10.3390\/brainsci7060067","article-title":"Neuropsychiatric burden in Huntington's disease","volume":"7","author":"Paoli","year":"2017","journal-title":"Brain Sci"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00175","article-title":"Psychiatric symptoms in amyotrophic lateral sclerosis: Beyond a motor neuron disorder","volume":"13","author":"Zucchi","year":"2019","journal-title":"Front Neurosci"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2013.12111460","article-title":"Behavioral and psychiatric symptoms in prion disease","volume":"171","author":"Thompson","year":"2014","journal-title":"Am J Psychiatry"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3928\/00485713-20120906-05","article-title":"Neuropsychiatric symptoms in lupus","volume":"42","author":"Gulinello","year":"2012","journal-title":"Psychiatr Ann"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.23.2.jnp121","article-title":"Anterior cingulate cortex: Unique role in cognition and emotion","volume":"23","author":"Stevens","year":"2011","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"B20","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.tics.2010.11.004","article-title":"Emotional processing in anterior cingulate and medial prefrontal cortex","volume":"15","author":"Etkin","year":"2011","journal-title":"Trends Cognit Sci"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2994","article-title":"The integration of negative affect, pain and cognitive control in the cingulate cortex","volume":"12","author":"Shackman","year":"2011","journal-title":"Nat Rev Neurosci"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-070815-013952","article-title":"Dorsal anterior cingulate cortex: A bottom-up view","volume":"39","author":"Heilbronner","year":"2016","journal-title":"Annu Rev Neurosci"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1704","article-title":"Pain and emotion interactions in subregions of the cingulate gyrus","volume":"6","author":"Vogt","year":"2005","journal-title":"Nat Rev Neurosci"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhy124","article-title":"Human pregenual anterior cingulate cortex: Structural, functional, and connectional heterogeneity","volume":"29","author":"Palomero-Gallagher","year":"2019","journal-title":"Cereb Cortex"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.08.035","article-title":"Cortical layers: Cyto-, myelo-, receptor- and synaptic architecture in human cortical areas","volume":"197","author":"Palomero-Gallagher","year":"2019","journal-title":"Neuroimage"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1111\/joa.13068","article-title":"Somato-dendritic morphology and axon origin site specify Von Economo neurons as a subclass of modified pyramidal neurons in the human anterior cingulate cortex","volume":"235","author":"Banovac","year":"2019","journal-title":"J Anat"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2011.10.004","article-title":"Von Economo neurons: Clinical and evolutionary perspectives","volume":"49","author":"Butti","year":"2013","journal-title":"Cortex"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21684","article-title":"Cytology and receptor architecture of human anterior cingulate cortex","volume":"508","author":"Palomero-Gallagher","year":"2008","journal-title":"J Comp Neurol"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2003.09.004","article-title":"Cytology of human dorsal midcingulate and supplementary motor cortices","volume":"26","author":"Vogt","year":"2003","journal-title":"J Chem Neuroanat"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2003.03034.x","article-title":"Structural and functional dichotomy of human midcingulate cortex","volume":"18","author":"Vogt","year":"2003","journal-title":"Eur J Neurosci"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.11.018","article-title":"Functional segregation of the human cingulate cortex is confirmed by functional connectivity based neuroanatomical parcellation","volume":"54","author":"Yu","year":"2011","journal-title":"Neuroimage"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1002\/cne.23409","article-title":"Cingulate area 32 homologies in mouse, rat, macaque and human: Cytoarchitecture and receptor architecture","volume":"521","author":"Vogt","year":"2013","journal-title":"J Comp Neurol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.neuron.2023.09.041","article-title":"Layer 1 neocortex: Gating and integrating multidimensional signals","volume":"112","author":"Huang","year":"2024","journal-title":"Neuron"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.0830-22.2023","article-title":"Cellular diversity in human subgenual anterior cingulate and dorsolateral prefrontal cortex by single-nucleus Rna-sequencing","volume":"43","author":"Kim","year":"2023","journal-title":"J Neurosci"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhae291","article-title":"Disentangling transcriptomic heterogeneity within the human subgenual anterior cingulate cortex","volume":"34","author":"Jenkins","year":"2024","journal-title":"Cereb Cortex"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhy286","article-title":"Transcriptomic landscape of Von Economo neurons in human anterior cingulate cortex revealed by microdissected-cell Rna sequencing","volume":"29","author":"Yang","year":"2019","journal-title":"Cereb Cortex"},{"key":"B37","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1111\/j.1749-6632.2011.06011.x","article-title":"The Von Economo neurons in the frontoinsular and anterior cingulate cortex","volume":"1225","author":"Allman","year":"2011","journal-title":"Ann N Y Acad Sci"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-014-0792-y","article-title":"An analysis of Von Economo neurons in the cerebral cortex of cetaceans, artiodactyls, and perissodactyls","volume":"220","author":"Raghanti","year":"2015","journal-title":"Brain Struct Funct"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1002\/ar.20829","article-title":"Von Economo neurons in the elephant brain","volume":"292","author":"Hakeem","year":"2009","journal-title":"Anat Rec (Hoboken)"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1002\/cne.22055","article-title":"Total number and volume of Von Economo neurons in the cerebral cortex of cetaceans","volume":"515","author":"Butti","year":"2009","journal-title":"J Comp Neurol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1002\/ar.22875","article-title":"The cerebral cortex of the pygmy hippopotamus, Hexaprotodon liberiensis (Cetartiodactyla, Hippopotamidae): Mri, cytoarchitecture, and neuronal morphology","volume":"297","author":"Butti","year":"2014","journal-title":"Anat Rec (Hoboken)"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2021.714611","article-title":"Von Economo neurons - Primate-specific or commonplace in the mammalian brain","volume":"15","author":"Banovac","year":"2021","journal-title":"Front Neural Circuits"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-010-0673-2","article-title":"Von Economo neuron density in the anterior cingulate cortex is reduced in early onset schizophrenia","volume":"119","author":"Br\u00fcne","year":"2010","journal-title":"Acta Neuropathol"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.08.067","article-title":"Von Economo neurons in autism: A stereologic study of the frontoinsular cortex in children","volume":"1380","author":"Santos","year":"2011","journal-title":"Brain Res"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhr004","article-title":"Selective frontoinsular Von Economo neuron and fork cell loss in early behavioral variant frontotemporal dementia","volume":"22","author":"Kim","year":"2012","journal-title":"Cereb Cortex"},{"key":"B46","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.cortex.2017.10.015","article-title":"Von Economo neurons of the anterior cingulate across the lifespan and in Alzheimer's disease","volume":"99","author":"Gefen","year":"2018","journal-title":"Cortex"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-021-00947-9","article-title":"The behavioral variant of Alzheimer's disease does not show a selective loss of Von Economo and phylogenetically related neurons in the anterior cingulate cortex","volume":"14","author":"Singleton","year":"2022","journal-title":"Alzheimers Res Ther"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-012-0493-3","article-title":"Cytoarchitecture of mouse and rat cingulate cortex with human homologies","volume":"219","author":"Vogt","year":"2014","journal-title":"Brain Struct Funct"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-016-1290-1","article-title":"Afferents to anterior cingulate areas 24a and 24b and midcingulate areas 24a' and 24b' in the mouse","volume":"222","author":"Fillinger","year":"2017","journal-title":"Brain Struct Funct"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-017-1585-x","article-title":"Efferents of anterior cingulate areas 24a and 24b and midcingulate areas 24a' and 24b' in the mouse","volume":"223","author":"Fillinger","year":"2018","journal-title":"Brain Struct Funct"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2003181117","article-title":"Divergence of rodent and primate medial frontal cortex functional connectivity","volume":"117","author":"Schaeffer","year":"2020","journal-title":"Proc Natl Acad Sci USA"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-007-0150-4","article-title":"Anatomical analysis of afferent projections to the medial prefrontal cortex in the rat","volume":"212","author":"Hoover","year":"2007","journal-title":"Brain Struct Funct"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1177\/17448069221094529","article-title":"Whole-brain mapping of efferent projections of the anterior cingulate cortex in adult male mice","volume":"18","author":"Shi","year":"2022","journal-title":"Mol Pain"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-071714-033936","article-title":"General cortical and special prefrontal connections: Principles from structure to function","volume":"38","author":"Barbas","year":"2015","journal-title":"Annu Rev Neurosci"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1523\/eneuro.0315-18.2018","article-title":"What, if anything, is rodent prefrontal cortex","volume":"5","author":"Laubach","year":"2018","journal-title":"eNeuro"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2003.09.003","article-title":"The medial prefrontal cortex in the rat: Evidence for a dorso-ventral distinction based upon functional and anatomical characteristics","volume":"27","author":"Heidbreder","year":"2003","journal-title":"Neurosci Biobehav Rev"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1620115114","article-title":"Opposing roles of primate areas 25 and 32 and their putative rodent homologs in the regulation of negative emotion","volume":"114","author":"Wallis","year":"2017","journal-title":"Proc Natl Acad Sci USA"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.2066-22.2023","article-title":"Subgenual and hippocampal pathways in amygdala are set to balance affect and context processing","volume":"43","author":"Joyce","year":"2023","journal-title":"J Neurosci"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.1056-21.2021","article-title":"Perigenual and subgenual anterior cingulate afferents converge on common pyramidal cells in amygdala subregions of the macaque","volume":"41","author":"Kelly","year":"2021","journal-title":"J Neurosci"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027839","article-title":"Default-mode-like network activation in awake rodents","volume":"6","author":"Upadhyay","year":"2011","journal-title":"PLoS One"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.06.012","article-title":"High trait anxiety and hyporeactivity to stress of the dorsomedial prefrontal cortex: A combined phmri and fos study in rats","volume":"23","author":"Kalisch","year":"2004","journal-title":"Neuroimage"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/s0006-8993(03)02299-6","article-title":"Excitotoxic lesions of the medial prefrontal cortex attenuate fear responses in the elevated-plus maze, social interaction and shock probe burying tests","volume":"969","author":"Shah","year":"2003","journal-title":"Brain Res"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2010.06.080","article-title":"Activity in prelimbic cortex is required for adjusting the anxiety response level during the elevated plus-maze retest","volume":"170","author":"Stern","year":"2010","journal-title":"Neuroscience"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1186\/1756-6606-4-6","article-title":"Neurabin in the anterior cingulate cortex regulates anxiety-like behavior in adult mice","volume":"4","author":"Kim","year":"2011","journal-title":"Mol Brain"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2009.08.038","article-title":"The anterior cingulate cortex is a target structure for the anxiolytic-like effects of benzodiazepines assessed by repeated exposure to the elevated plus maze and fos immunoreactivity","volume":"164","author":"Albrechet-Souza","year":"2009","journal-title":"Neuroscience"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2007.05844.x","article-title":"Distinct contributions of frontal areas to emotion and social behaviour in the rat","volume":"26","author":"Rudebeck","year":"2007","journal-title":"Eur J Neurosci"},{"key":"B67","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/s0166-4328(01)00452-1","article-title":"Evaluation of the elevated plus-maze and open-field tests for the assessment of anxiety-related behaviour in inbred mice","volume":"134","author":"Carola","year":"2002","journal-title":"Behav Brain Res"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(80)90067-2","article-title":"Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines","volume":"13","author":"Crawley","year":"1980","journal-title":"Pharmacol Biochem Behav"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1016\/s0006-3223(02)01827-9","article-title":"Validation of a simple, ethologically relevant paradigm for assessing anxiety in mice","volume":"54","author":"Merali","year":"2003","journal-title":"Biol Psychiatry"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2011.361","article-title":"A standardized protocol for repeated social defeat stress in mice","volume":"6","author":"Golden","year":"2011","journal-title":"Nat Protoc"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.5587-06.2007","article-title":"Dissociable intrinsic connectivity networks for salience processing and executive control","volume":"27","author":"Seeley","year":"2007","journal-title":"J Neurosci"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.07.029","article-title":"Resolving emotional conflict: A role for the rostral anterior cingulate cortex in modulating activity in the amygdala","volume":"51","author":"Etkin","year":"2006","journal-title":"Neuron"},{"key":"B73","doi-asserted-by":"crossref","DOI":"10.1002\/(SICI)1096-9861(20000529)421:2<172::AID-CNE4>3.0.CO;2-8","article-title":"Subcortical projections of area 25 (subgenual cortex) of the macaque monkey","volume":"421","author":"Freedman","year":"2000","journal-title":"J Comp Neurol"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhaa333","article-title":"Pathways for contextual memory: The primate hippocampal pathway to anterior cingulate cortex","volume":"31","author":"Wang","year":"2021","journal-title":"Cereb Cortex"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2018.05.028","article-title":"Afferent connections of the dorsal, perigenual, and subgenual anterior cingulate cortices of the monkey: Amygdalar inputs and intrinsic connections","volume":"681","author":"Kim","year":"2018","journal-title":"Neurosci Lett"},{"key":"B76","doi-asserted-by":"publisher","first-page":"8050","DOI":"10.1523\/JNEUROSCI.0982-16.2016","article-title":"Contributions of the central extended amygdala to fear and anxiety","volume":"36","author":"Shackman","year":"2016","journal-title":"J Neurosci"},{"key":"B77","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.neulet.2017.11.056","article-title":"The central extended amygdala in fear and anxiety: Closing the gap between mechanistic and neuroimaging research","volume":"693","author":"Fox","year":"2019","journal-title":"Neurosci Lett"},{"key":"B78","doi-asserted-by":"publisher","first-page":"5386","DOI":"10.1038\/s41467-020-19167-0","article-title":"Over-activation of primate subgenual cingulate cortex enhances the cardiovascular, behavioral and neural responses to threat","volume":"11","author":"Alexander","year":"2020","journal-title":"Nat Commun"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.ade1779","article-title":"Chemogenetics identifies separate area 25 brain circuits involved in anhedonia and anxiety in marmosets","volume":"15","author":"Wood","year":"2023","journal-title":"Sci Transl Med"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.0810-19.2019","article-title":"Anterior cingulate cortex and ventral hippocampal inputs to the basolateral amygdala selectively control generalized fear","volume":"39","author":"Ortiz","year":"2019","journal-title":"J Neurosci"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.67007","article-title":"The anterior cingulate cortex and its role in controlling contextual fear memory to predatory threats","volume":"11","author":"de Lima","year":"2022","journal-title":"Elife"},{"key":"B82","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1016\/j.cub.2018.03.012","article-title":"Ventral hippocampal ca1 and ca3 differentially mediate learned approach-avoidance conflict processing","volume":"28","author":"Schumacher","year":"2018","journal-title":"Curr Biol"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.22554","article-title":"Dissociable contributions of amygdala and hippocampus to emotion and memory in patients with Alzheimer's disease","volume":"26","author":"Guzm\u00e1n-V\u00e9lez","year":"2016","journal-title":"Hippocampus"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2019.00242","article-title":"Emotion regulation of hippocampus using real-time fmri neurofeedback in healthy human","volume":"13","author":"Zhu","year":"2019","journal-title":"Front Hum Neurosci"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2014.01.046","article-title":"Human hippocampus arbitrates approach-avoidance conflict","volume":"24","author":"Bach","year":"2014","journal-title":"Curr Biol"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.77364","article-title":"No evidence from complementary data sources of a direct glutamatergic projection from the mouse anterior cingulate area to the hippocampal formation","volume":"12","author":"Andrianova","year":"2023","journal-title":"Elife"},{"key":"B87","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.brainresrev.2007.05.002","article-title":"Spatial organization of direct hippocampal field ca1 axonal projections to the rest of the cerebral cortex","volume":"56","author":"Cenquizca","year":"2007","journal-title":"Brain Res Rev"},{"key":"B88","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/s00429-011-0345-6","article-title":"Collateral projections from nucleus reuniens of thalamus to hippocampus and medial prefrontal cortex in the rat: A single and double retrograde fluorescent labeling study","volume":"217","author":"Hoover","year":"2012","journal-title":"Brain Struct Funct"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903130404","article-title":"Distribution of hippocampal ca1 and subicular efferents in the prefrontal cortex of the rat studied by means of anterograde transport of phaseolus vulgaris-leucoagglutinin","volume":"313","author":"Jay","year":"1991","journal-title":"J Comp Neurol"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.12.002","article-title":"Synchronized activity between the ventral hippocampus and the medial prefrontal cortex during anxiety","volume":"65","author":"Adhikari","year":"2010","journal-title":"Neuron"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.01.011","article-title":"Direct ventral hippocampal-prefrontal input is required for anxiety-related neural activity and behavior","volume":"89","author":"Padilla-Coreano","year":"2016","journal-title":"Neuron"},{"key":"B92","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/j.neuron.2019.08.006","article-title":"Hippocampal-prefrontal theta transmission regulates avoidance behavior","volume":"104","author":"Padilla-Coreano","year":"2019","journal-title":"Neuron"},{"key":"B93","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1038\/s41467-022-27977-7","article-title":"Two opposing hippocampus to prefrontal cortex pathways for the control of approach and avoidance behaviour","volume":"13","author":"S\u00e1nchez-Bellot","year":"2022","journal-title":"Nat Commun"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-013-0543-5","article-title":"Anatomical substrates for direct interactions between hippocampus, medial prefrontal cortex, and the thalamic nucleus reuniens","volume":"219","author":"Varela","year":"2014","journal-title":"Brain Struct Funct"},{"key":"B95","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1101\/lm.048389.118","article-title":"The nucleus reuniens of the thalamus sits at the nexus of a hippocampus and medial prefrontal cortex circuit enabling memory and behavior","volume":"26","author":"Dolleman-van der Weel","year":"2019","journal-title":"Learn Mem"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1002\/cne.23368","article-title":"Anterior insular cortex and emotional awareness","volume":"521","author":"Gu","year":"2013","journal-title":"J Comp Neurol"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20705","article-title":"Two systems of resting state connectivity between the insula and cingulate cortex","volume":"30","author":"Taylor","year":"2009","journal-title":"Hum Brain Mapp"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1038\/nn1176","article-title":"Neural systems supporting interoceptive awareness","volume":"7","author":"Critchley","year":"2004","journal-title":"Nat Neurosci"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21503","article-title":"Anatomical and functional overlap within the insula and anterior cingulate cortex during interoception and phobic symptom provocation","volume":"34","author":"Caseras","year":"2013","journal-title":"Hum Brain Mapp"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2011.10.010","article-title":"Insula reactivity and connectivity to anterior cingulate cortex when processing threat in generalized social anxiety disorder","volume":"89","author":"Klumpp","year":"2012","journal-title":"Biol Psychol"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2018.00100","article-title":"Structural connectivity of the anterior cingulate cortex, claustrum, and the anterior insula of the mouse","volume":"12","author":"Qadir","year":"2018","journal-title":"Front Neuroanat"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2014.05.017","article-title":"Insular muscarinic signaling regulates anxiety-like behaviors in rats on the elevated plus-maze","volume":"270","author":"Li","year":"2014","journal-title":"Behav Brain Res"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00330","article-title":"The role of the rodent insula in anxiety","volume":"10","author":"M\u00e9ndez-Ruette","year":"2019","journal-title":"Front Physiol"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2015.185","article-title":"The human Bnst: Functional role in anxiety and addiction","volume":"41","author":"Avery","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"B105","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0306-4522(88)90217-5","article-title":"New perspectives in basal forebrain organization of special relevance for neuropsychiatric disorders: The striatopallidal, amygdaloid, and corticopetal components of substantia innominata","volume":"27","author":"Alheid","year":"1988","journal-title":"Neuroscience"},{"key":"B106","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-1-4757-0145-6_1","article-title":"Piecing together the puzzle of basal forebrain anatomy","volume":"295","author":"Heimer","year":"1991","journal-title":"Adv Exp Med Biol"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2016.1","article-title":"Overshadowed by the amygdala: The bed nucleus of the stria terminalis emerges as key to psychiatric disorders","volume":"21","author":"Lebow","year":"2016","journal-title":"Mol Psychiatry"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2009.109","article-title":"Phasic vs sustained fear in rats and humans: Role of the extended amygdala in fear vs anxiety","volume":"35","author":"Davis","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.60812","article-title":"A prefrontal-bed nucleus of the stria terminalis circuit limits fear to uncertain threat","volume":"9","author":"Glover","year":"2020","journal-title":"Elife"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1038\/nature12018","article-title":"Diverging neural pathways assemble a behavioural state from separable features in anxiety","volume":"496","author":"Kim","year":"2013","journal-title":"Nature"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2015.00321","article-title":"Temporary inactivation of the anterior part of the bed nucleus of the stria terminalis blocks alarm pheromone-induced defensive behavior in rats","volume":"9","author":"Breitfeld","year":"2015","journal-title":"Front Neurosci"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1038\/nature12041","article-title":"Distinct extended amygdala circuits for divergent motivational states","volume":"496","author":"Jennings","year":"2013","journal-title":"Nature"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1016\/s0028-3932(02)00325-1","article-title":"The effect of cingulate lesions on social behaviour and emotion","volume":"41","author":"Hadland","year":"2003","journal-title":"Neuropsychologia"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1016\/s1364-6613(00)01483-2","article-title":"Cognitive and emotional influences in anterior cingulate cortex","volume":"4","author":"Bush","year":"2000","journal-title":"Trends Cognit Sci"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1126\/science.1128197","article-title":"A role for the macaque anterior cingulate gyrus in social valuation","volume":"313","author":"Rudebeck","year":"2006","journal-title":"Science"},{"key":"B116","doi-asserted-by":"crossref","DOI":"10.1139\/jpn.0342","article-title":"Anterior cingulate dysfunction: Implications for psychiatric disorders","volume":"28","author":"Y\u00fccel","year":"2003","journal-title":"J Psychiatry Neurosci"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0b013e328305b722","article-title":"Anxiety vulnerability is associated with altered anterior cingulate response to an affective appraisal task","volume":"19","author":"Simmons","year":"2008","journal-title":"Neuroreport"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2024.07.001","article-title":"Multiple faces of anxiety: A frontal lobe perspective","volume":"47","author":"Roberts","year":"2024","journal-title":"Trends Neurosci"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1016\/j.janxdis.2023.102773","article-title":"A systematic review and meta-analysis of resting-state fmri in anxiety disorders: Need for data sharing to move the field forward","volume":"99","author":"Zugman","year":"2023","journal-title":"J Anxiety Disord"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2009.09070931","article-title":"Failure of anterior cingulate activation and connectivity with the amygdala during implicit regulation of emotional processing in generalized anxiety disorder","volume":"167","author":"Etkin","year":"2010","journal-title":"Am J Psychiatry"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2009.104","article-title":"Disrupted amygdalar subregion functional connectivity and evidence of a compensatory network in generalized anxiety disorder","volume":"66","author":"Etkin","year":"2009","journal-title":"Arch Gen Psychiatry"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.2178","article-title":"Reduced structural connectivity of a major frontolimbic pathway in generalized anxiety disorder","volume":"69","author":"Tromp","year":"2012","journal-title":"Arch Gen Psychiatry"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2008.07101682","article-title":"Anticipatory activation in the amygdala and anterior cingulate in generalized anxiety disorder and prediction of treatment response","volume":"166","author":"Nitschke","year":"2009","journal-title":"Am J Psychiatry"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(08)60488-2","article-title":"Social anxiety disorder","volume":"371","author":"Stein","year":"2008","journal-title":"Lancet"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.01.044","article-title":"Increased activation of the anterior cingulate cortex during processing of disgust faces in individuals with social phobia","volume":"57","author":"Amir","year":"2005","journal-title":"Biol Psychiatry"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2013.09.005","article-title":"Anterior cingulate cortex involvement in subclinical social anxiety","volume":"214","author":"Duval","year":"2013","journal-title":"Psychiatry Res"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200502080-00024","article-title":"Anterior cingulate neurochemistry in social anxiety disorder: 1h-mrs at 4 tesla","volume":"16","author":"Phan","year":"2005","journal-title":"Neuroreport"},{"key":"B128","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1586\/ern.09.161","article-title":"Current findings of fmri in panic disorder: Contributions for the fear neurocircuitry and cbt effects","volume":"10","author":"de Carvalho","year":"2010","journal-title":"Expert Rev Neurother"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1819.2008.01800.x","article-title":"Anterior cingulate cortex volume reduction in patients with panic disorder","volume":"62","author":"Asami","year":"2008","journal-title":"Psychiatry Clin Neurosci"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2007.04.015","article-title":"Regional gray matter abnormalities in panic disorder: A voxel-based morphometry study","volume":"163","author":"Uchida","year":"2008","journal-title":"Psychiatry Res"},{"key":"B131","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.jpsychires.2007.03.002","article-title":"Altered cingulate white matter connectivity in panic disorder patients","volume":"42","author":"Han","year":"2008","journal-title":"J Psychiatr Res"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2006.04.007","article-title":"Fmri of fearful facial affect recognition in panic disorder: The cingulate gyrus-amygdala connection","volume":"94","author":"Pillay","year":"2006","journal-title":"J Affect Disord"},{"key":"B133","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","year":"2013"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-3956(00)00022-4","article-title":"Fmri of neuronal activation with symptom provocation in unmedicated patients with obsessive compulsive disorder","volume":"34","author":"Adler","year":"2000","journal-title":"J Psychiatr Res"},{"key":"B135","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1001\/archpsyc.1994.03950010062008","article-title":"Regional cerebral blood flow measured during symptom provocation in obsessive-compulsive disorder using oxygen 15-labeled carbon dioxide and positron emission tomography","volume":"51","author":"Rauch","year":"1994","journal-title":"Arch Gen Psychiatry"},{"key":"B136","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1186\/s12888-019-2160-1","article-title":"Investigation of anterior cingulate cortex gamma-aminobutyric acid and glutamate-glutamine levels in obsessive-compulsive disorder using magnetic resonance spectroscopy","volume":"19","author":"Li","year":"2019","journal-title":"BMC Psychiatry"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1097\/01.chi.0000132812.44664.2d","article-title":"Reduced anterior cingulate glutamatergic concentrations in childhood ocd and major depression versus healthy controls","volume":"43","author":"Rosenberg","year":"2004","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"B138","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1007\/s11055-020-00901-6","article-title":"Dynamics of activity in the anterior cingulate cortex on development of obsessive-compulsive disorder: A combined pet and fmri study","volume":"50","author":"Medvedeva","year":"2020","journal-title":"Neurosci Behav Physiol"},{"key":"B139","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.pscychresns.2013.03.002","article-title":"Regional cerebral volumes in veterans with current versus remitted posttraumatic stress disorder","volume":"213","author":"Chao","year":"2013","journal-title":"Psychiatry Res"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.07.033","article-title":"Decreased anterior cingulate volume in combat-related ptsd","volume":"59","author":"Woodward","year":"2006","journal-title":"Biol Psychiatry"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2018.08.006","article-title":"Association among anterior cingulate cortex volume, psychophysiological response, and ptsd diagnosis in a veteran sample","volume":"155","author":"Young","year":"2018","journal-title":"Neurobiol Learn Mem"},{"key":"B142","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/(SICI)1520-6394(1999)9:1<1::AID-DA1>3.0.CO;2-4","article-title":"Potential role of the anterior cingulate cortex in ptsd: Review and hypothesis","volume":"9","author":"Hamner","year":"1999","journal-title":"Depress Anxiety"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1186\/2045-5380-2-9","article-title":"Quantitative meta-analysis of neural activity in posttraumatic stress disorder","volume":"2","author":"Hayes","year":"2012","journal-title":"Biol Mood Anxiety Disord"},{"key":"B144","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1159\/000351938","article-title":"Neuroimaging in anxiety disorders","volume":"29","author":"Frederikson","year":"2013","journal-title":"Mod Trends Parmacopsychiatry"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1016\/s0006-3223(01)01215-x","article-title":"An fmri study of anterior cingulate function in posttraumatic stress disorder","volume":"50","author":"Shin","year":"2001","journal-title":"Biol Psychiatry"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1016\/s0006-3223(98)00297-2","article-title":"Neural correlates of exposure to traumatic pictures and sound in Vietnam combat veterans with and without posttraumatic stress disorder: A positron emission tomography study","volume":"45","author":"Bremner","year":"1999","journal-title":"Biol Psychiatry"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2012.08.011","article-title":"Reduced neural activation during an inhibition task is associated with impaired fear inhibition in a traumatized civilian sample","volume":"49","author":"Jovanovic","year":"2013","journal-title":"Cortex"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200507130-00004","article-title":"Disrupted white matter tract integrity of anterior cingulate in trauma survivors","volume":"16","author":"Kim","year":"2005","journal-title":"Neuroreport"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1111\/pcn.12332","article-title":"Proton magnetic resonance spectroscopy revealed differences in the glutamate + glutamine\/creatine ratio of the anterior cingulate cortex between healthy and pediatric post-traumatic stress disorder patients diagnosed after 2008 Wenchuan earthquake","volume":"69","author":"Yang","year":"2015","journal-title":"Psychiatry Clin Neurosci"},{"key":"B150","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1177\/0004867418812674","article-title":"Altered resting-state dorsal anterior cingulate cortex functional connectivity in patients with post-traumatic stress disorder","volume":"53","author":"Chen","year":"2019","journal-title":"Aust N Z J Psychiatry"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.1159\/000358822","article-title":"Correlation between both morphologic and functional changes and anxiety in Alzheimer's disease","volume":"38","author":"Tagai","year":"2014","journal-title":"Dement Geriatr Cognit Disord"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2024.1487875","article-title":"The neural basis of neuropsychiatric symptoms in Alzheimer's disease","volume":"16","author":"Zhang","year":"2024","journal-title":"Front Aging Neurosci"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13076","article-title":"Neuroimaging correlates of neuropsychiatric symptoms in Alzheimer's disease: A review of 20 years of research","volume":"23","author":"Boublay","year":"2016","journal-title":"Eur J Neurol"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.3233\/jad-150181","article-title":"Associations between neuropsychiatric symptoms and cerebral amyloid deposition in cognitively impaired elderly people","volume":"49","author":"Bensamoun","year":"2016","journal-title":"J Alzheimers Dis"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2016.10.021","article-title":"Neural correlates of anxiety symptoms in mild Parkinson's disease: A prospective longitudinal voxel-based morphometry study","volume":"371","author":"Wee","year":"2016","journal-title":"J Neurol Sci"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28404","article-title":"Neuroimaging of anxiety in Parkinson's disease: A systematic review","volume":"36","author":"Carey","year":"2021","journal-title":"Mov Disord"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww162","article-title":"The prominent role of serotonergic degeneration in apathy, anxiety and depression in de novo Parkinson's disease","volume":"139","author":"Maillet","year":"2016","journal-title":"Brain"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh445","article-title":"Depression in Parkinson's disease: Loss of dopamine and noradrenaline innervation in the limbic system","volume":"128","author":"Remy","year":"2005","journal-title":"Brain"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301048","article-title":"Association of the Val158met catechol O-methyltransferase genetic polymorphism with panic disorder","volume":"31","author":"Rothe","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.1016\/s0896-6273(00)80491-2","article-title":"Corticotropin releasing factor receptor 1-deficient mice display decreased anxiety, impaired stress response, and aberrant neuroendocrine development","volume":"20","author":"Smith","year":"1998","journal-title":"Neuron"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-020-00949-5","article-title":"Deep transcriptome sequencing of subgenual anterior cingulate cortex reveals cross-diagnostic and diagnosis-specific RNA expression changes in major psychiatric disorders","volume":"46","author":"Akula","year":"2021","journal-title":"Neuropsychopharmacology"},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00814","article-title":"Differentially expressed genes in the brain of aging mice with cognitive alteration and depression- and anxiety-like behaviors","volume":"8","author":"Li","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyz004","article-title":"Epigenetic mechanisms within the cingulate cortex regulate innate anxiety-like behavior","volume":"22","author":"Sah","year":"2019","journal-title":"Int J Neuropsychopharmacol"},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.992130","article-title":"The anterior cingulate cortex contributes to the analgesic rather than the anxiolytic effects of duloxetine in chronic pain-induced anxiety","volume":"16","author":"Li","year":"2022","journal-title":"Front Neurosci"},{"key":"B165","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-021-01211-2","article-title":"Anterior cingulate cortex activation during attentional control as a transdiagnostic marker of psychotherapy response: A randomized clinical trial","volume":"47","author":"Feurer","year":"2022","journal-title":"Neuropsychopharmacology"},{"key":"B166","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2015.00212","article-title":"Short-term meditation increases blood flow in anterior cingulate cortex and insula","volume":"6","author":"Tang","year":"2015","journal-title":"Front Psychol"}],"container-title":["Frontiers in Psychiatry"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpsyt.2026.1719721\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:45:58Z","timestamp":1787741158000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpsyt.2026.1719721\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,26]]},"references-count":166,"alternative-id":["10.3389\/fpsyt.2026.1719721"],"URL":"https:\/\/doi.org\/10.3389\/fpsyt.2026.1719721","relation":{},"ISSN":["1664-0640"],"issn-type":[{"value":"1664-0640","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,26]]},"article-number":"1719721"}}