{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T11:56:22Z","timestamp":1781697382705,"version":"3.54.5"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Transcranial magnetic stimulation (TMS) is an established treatment option for major depressive disorder (MDD) but is currently limited to clinical settings such as hospitals or doctors\u2019 offices. Technical and logistical challenges have so far prevented its application in patients\u2019 homes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this pilot study, five outpatients with MDD (aged 29\u201365 years), living up to 120 km from a tertiary care hospital (Regensburg, Germany), received home-based TMS treatment using an accelerated intermittent theta burst stimulation protocol (aiTBS; 5 sessions per day, 1800 pulses per session). Treatment was delivered using a conventional DuoMAG XT-100 device (Deymed Diagnostics, Hronov, Czech Republic). Feasibility was evaluated through assessment of logistical challenges, device handling, safety, treatment tolerability and patient satisfaction. Depressive symptoms were measured before and after treatment using the 21-item Hamilton Depression Rating Scale (HAMD-21) and the Major Depression Inventory (MDI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Home-based TMS treatment was feasible with no serious adverse events reported. A reduction in depressive symptom scores was observed. Major logistical challenges included device transport, space requirements and the need for trained personnel on site.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our pilot data demonstrate the feasibility of home-based TMS using a conventional clinical device, while highlighting substantial technical and logistical limitations. These limitations underscore the urgent need for the development of lightweight, portable and patient-friendly TMS devices to facilitate the delivery of neurostimulation therapies beyond clinical settings. Further studies with larger samples are warranted, using randomized controlled designs comparing home-based and clinic-based TMS to evaluate not only feasibility, but also efficacy under standardized conditions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpsyt.2026.1731673","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T06:46:49Z","timestamp":1773384409000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Feasibility of home-based accelerated intermittent theta-burst stimulation (aiTBS) for depression: a case series"],"prefix":"10.3389","volume":"17","author":[{"given":"Katharina","family":"Kerkel","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University of Regensburg","place":["Regensburg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Reissmann","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University of Regensburg","place":["Regensburg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berthold","family":"Langguth","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University of Regensburg","place":["Regensburg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirja","family":"Osnabruegge","sequence":"additional","affiliation":[{"name":"Institute of Psychology, Universit\u00e4t der Bundeswehr M\u00fcnchen","place":["Neubiberg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo","family":"Tomasevic","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University of Regensburg","place":["Regensburg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karsten","family":"Litschel","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering, Universit\u00e4t der Bundeswehr M\u00fcnchen","place":["Neubiberg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Kuder","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering, Universit\u00e4t der Bundeswehr M\u00fcnchen","place":["Neubiberg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Schecklmann","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University of Regensburg","place":["Regensburg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Schoisswohl","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University of Regensburg","place":["Regensburg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,13]]},"reference":[{"key":"B1","unstructured":"Depression\n          \n          \n          \n          2025"},{"key":"B2","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1017\/S1461145713001065","article-title":"Differential improvement in depressive symptoms for tDCS alone and combined with pharmacotherapy: an exploratory analysis from the Sertraline vs. Electrical Current Therapy for Treating Depression Clinical Study","volume":"17","author":"Brunoni","year":"2014","journal-title":"Int J Neuropsychopharmacol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1016\/j.clinph.2019.11.002","article-title":"Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS): An update, (2014-2018)","volume":"131","author":"Lefaucheur","year":"2020","journal-title":"Clin neurophysiol: Off J Int Fed Clin Neurophysiol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2023.115429","article-title":"Accelerated intermittent theta burst stimulation in major depressive disorder:\u00a0A\u00a0systematic review","volume":"327","author":"Neuteboom","year":"2023","journal-title":"Psychiatry Res"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-33-6044-0_18","article-title":"Current updates on newer forms of transcranial magnetic stimulation in major depression. 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